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Paxinos, G. (2001) · Cited by 12,859

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358

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Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

Schmedtje, J. F., Ji, Y.-S., Liu, W. L., DuBois, R. N., & Runge, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.601 · Cited by 668

Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

Chakravarty, S., & Herkenham, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4268-04.2005 · Cited by 396

Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway

Murakami, M., & Kudo, I. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00037-7 · Cited by 376

Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

Yamagata, K., Matsumura, K., Inoue, W., Shiraki, T., Suzuki, K., Yasuda, S., Sugiura, H., Cao, C., Watanabe, Y., & Kobayashi, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02669.2001 · Cited by 372

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Simard, A. R., & Rivest, S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1517fje · Cited by 362

Pathway across the blood–brain barrier

Ek, M., Engblom, D., Saha, S., Blomqvist, A. G., Jakobsson, P., & Ericsson‐Dahlstrand, A. (2001) · Nature · doi:10.1038/35068632 · Cited by 347

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

Engblom, D., Saha, S., Engström, L., Westman, M., Audoly, L., Jakobsson, P., & Blomqvist, A. G. (2003) · Nature Neuroscience · doi:10.1038/nn1137 · Cited by 310

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1996) · Brain Research · doi:10.1016/0006-8993(96)00575-6 · Cited by 308

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Laflamme, N., Lacroix, S., & Rivest, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10923.1999 · Cited by 287

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Ericsson, A. B., Arias, C., & Sawchenko, P. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07166.1997 · Cited by 278

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Li, S., Wang, Y., Matsumura, K., Ballou, L. R., Morham, S. G., & Blatteis, C. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01225-1 · Cited by 270

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Scammell, T. E., Elmquist, J. K., Griffin, J. D., & Saper, C. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06246.1996 · Cited by 249

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Crofford, L. J., Tan, B., McCarthy, C. J., & Hla, T. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400207 · Cited by 248

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Matsumura, K., Cao, C., Ozaki, M., Morii, H., Nakadate, K., & Watanabe, Y. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06279.1998 · Cited by 247

Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity

Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245

Adrenocorticotropin Release Induced by Intracerebroventricular Injection of Recombinant Human Interleukin-1 in Rats: Possible Involvement of Prostaglandin*

Katsuura, G., Gottschall, P. E., Dahl, R. R., & Arimura, A. (1988) · Endocrinology · doi:10.1210/endo-122-5-1773 · Cited by 216

Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1712 · Cited by 203

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Schiltz, J. C., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05606.2002 · Cited by 197

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Rivest, S. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00064-6 · Cited by 195

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Inoue, H., & Tanabe, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8222 · Cited by 185

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Laflamme, N., & Rivest, S. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730309.x · Cited by 182

Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide

Quan, N., Whiteside, M. B., & Herkenham, M. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00402-8 · Cited by 172

Cooperation between toll‐like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram‐negative and gram‐positive bacteria

Laflamme, N., Echchannaoui, H., Landmann, R. M., & Rivest, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200323821 · Cited by 158

Basal expression of cyclooxygenase-2 and nuclear factor–interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet

SORLI, C. H., Zhang, H.-J., Armstrong, M. B., Rajotte, R. V., Maclouf, J., & Robertson, R. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1788 · Cited by 139

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Sawchenko, P. E. (2003) · Frontiers in bioscience · doi:10.2741/1211 · Cited by 126

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Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107

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Cao, C., Matsumura, K., Ozaki, M., & Watanabe, Y. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00716.1999 · Cited by 105

Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1β

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Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00025-4 · Cited by 101

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Watanabe, T., Morimoto, A., Sakata, Y., & Murakami, N. (1990) · Cellular and Molecular Life Sciences · doi:10.1007/bf01954238 · Cited by 92

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Rivest, S. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000676 · Cited by 76

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Blais, V., & Rivest, S. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.893 · Cited by 63

Protein–protein interactions involving inducible nitric oxide synthase

Zhang, W., Kuncewicz, T., Yu, Z. ‐., Zou, L., Xu, X., & Kone, B. C. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01119.x · Cited by 49

Microinjection of prostaglandin E2 and muscimol into the preoptic area in conscious rats: Comparison of effects on plasma adrenocorticotrophic hormone (ACTH), body temperature, locomotor activity, and cardiovascular function

Zaretsky, D. V., Hunt, J. L., Zaretskaia, M. V., & DiMicco, J. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.032 · Cited by 47

Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development

Weiner, J. A., & Chun, J. J. M. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970505)381:2 · Cited by 46

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Rivest, S. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000679 · Cited by 44

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Steiner, A. A., Rudaya, A. Y., Robbins, J. R., Dragic, A. S., Langenbach, R., & Romanovsky, A. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00371.2005 · Cited by 42

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Zhang, J., & Rivest, S. (2003) · Physiology · doi:10.1152/nips.01415.2002 · Cited by 31

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Cao, C., Matsumura, K., & Watanabe, Y. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51710.x · Cited by 28

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Turrin, N. P., Plante, M.-M., Lessard, M., & Rivest, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0508 · Cited by 27

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Blais, V., Zhang, J., & Rivest, S. (2002) · Endocrinology · doi:10.1210/en.2002-220598 · Cited by 22

Central administration of prostaglandin E2 suppresses in vitro cellular immune responses

Rassnick, S., Zhou, D., & Rabin, B. S. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.1.r92 · Cited by 22

Intraventricular infusion of antagonists of IL-1 and TNFα attenuates neurodegeneration induced by the infection of Trypanosoma brucei

Quan, N., He, L., & Lai, W. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00122-x · Cited by 20

Electron Microscopic Evidence for Induction of Cyclooxygenase‐2 in Brain Endothelial Cells

Matsumura, K., Cao, C., OZAKI, M., Morii, H., Nakadate, K., & Watanabe, Y. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08338.x · Cited by 15

Untitled work

Huttenlocher (1997) · doi:10.1002/(sici)1096-9861(19971020)387:2

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Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192

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D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675

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Krasnow, S., Knoll, J., Verghese, S. C., Levasseur, P., & Marks, D. (2017) · Figshare · doi:10.6084/m9.figshare.c.3816463_d1

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Hua, F., Wang, J., Ishrat, T., Prunty, M. C., Atif, F., Sayeed, I., Gewirtz, A. T., & Stein, D. G. (2012) · Stroke · doi:10.1161/str.43.suppl_1.a3676