Cited by 167Treatment of Major DepressionNerve injury and regenerationNeuroscience and Neuropharmacology Research

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Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Xu, Haiyun, Steven Richardson, J, Li, Xin-Min·2003·Neuropsychopharmacology

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Abstract

It has been proposed that antidepressants have neuroprotective effects on hippocampal neurons. To further test this hypothesis, brain-derived neurotrophic factor (BDNF), B cell lymphoma protein-2 (Bcl-2), and copper-zinc superoxide dismutase (Cu/Zn-SOD) were examined immunohistochemically in hippocampal neurons of Sprague-Dawley rats following daily treatment with 5 or 10 mg/kg of amitriptyline or venlafaxine for 21 days. At 5 mg/kg, both amitriptyline and venlafaxine increased the intensity of BDNF immunostaining in hippocampal pyramidal neurons, and the intensity of Bcl-2 immunostaining in hippocampal mossy fibers, but did not alter the Cu/Zn-SOD immunoreactivity. The high dose of venlafaxine, however, decreased the intensity of BDNF immunostaining in all subareas of the hippocampus and increased the intensity of Cu/Zn-SOD immunostaining in the dentate granular cell layer. The high dose of amitriptyline increased the intensity of Cu/Zn-SOD immunostaining, but did not affect the immunoreactivity of Bcl-2 or BDNF. These findings suggest that the chronic administration of amitriptyline or venlafaxine at 5 mg/kg, but not 10 mg/kg, may be neuroprotective to hippocampal neurons. These dose-related effects of antidepressant drugs on hippocampal neurons may have relevance to disparate findings in the field.

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THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,568
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Norepinephrine in Depressive Reactions
Bunney, W. E. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01730060001001 · Cited by 1,166
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841
Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
Greenlund, L. J. S., Deckwerth, T. L., & Johnson, E. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90287-2 · Cited by 738
Untitled work
(2000) · PubMed · Cited by 685

Show all 60 references

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Schmidt, A. J., Heiser, P., Hemmeter, U. M., Krieg, J.-C., & Vedder, H. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.024 · Cited by 40
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Kumar, P., Kalonia, H., & Kumar, A. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110364269 · Cited by 38
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Jasmin, L., Tien, D. A., Janni, G., & Ohara, P. T. (2003) · Pain · doi:10.1016/j.pain.2003.08.010 · Cited by 38
Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by a neurotoxic regimen of dl-amphetamine in rats
He, J., Xu, H., Yang, Y., Zhang, X., & Li, X. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.028 · Cited by 37
Self-citation
Behavioral effects of Bcl-2 deficiency: implications for affective disorders.
Lien, R., Flaisher-Grinberg, S., Cleary, C., Hejny, M., & Einat, H. (2008) · PubMed · Cited by 37
Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment
Tsai, S. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.05.035 · Cited by 37
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Réus, G. Z., Abelaira, H. M., Agostinho, F. R., Ribeiro, K. F., Vitto, M. F., Luciano, T. F., de Souza, C. T., & Quevedo, J. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.016 · Cited by 35
Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine
Shah, A. P., Carreno, F. R., Wu, H., Chung, Y. A., & Frazer, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.024 · Cited by 37
The β3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes
Tamburella, A., Micale, V., Leggio, G. M., & Drago, F. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.04.006 · Cited by 35
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Lee, T.-K., Park, J. H., Ahn, J. H., Shin, M. C., Cho, J. H., Bae, E. J., Kim, Y., Won, M., & Lee, C. H. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.09.059 · Cited by 34
Shuyu capsules relieve liver‑qi depression by regulating ERK‑CREB‑BDNF signal pathway in central nervous system of rat
Wang, H., Zhang, Y., Li, H., Zeng, W., & Qiao, M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5125 · Cited by 29
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Jantas, D., Krawczyk, S., & Lasoń, W. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9430-3 · Cited by 29
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Malkesman, O., Austin, D. R., Tragon, T. R., Henter, I. D., Reed, J. C., Pellecchia, M., Chen, G., & Manji, H. K. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.77 · Cited by 28
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Motaghinejad, M., Motevalian, M., Ebrahimzadeh, A., Larijani, S. F., & Khajehamedi, Z. (2015) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.158181 · Cited by 28
Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system
Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B. T., Daley, B. F., & Collier, T. J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.02.005 · Cited by 28
Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine
McHugh, P., Rogers, G., Glubb, D., Joyce, P., & Kennedy, M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109102786 · Cited by 25
Venlafaxine exerts antidepressant effects possibly by activating MAPK–ERK1/2 and P13K–AKT pathways in the hippocampus
Shen, P., Hu, Q., Dong, M.-X., Bai, S., Liang, Z., Chen, Z., Li, P., Hu, Z., Zhong, X., Zhu, D., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.011 · Cited by 26
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Ghaemi, S. N. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13459 · Cited by 26
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Sołek, P., Koszła, O., Mytych, J., Badura, J., Chelminiak, Z., Cuprys, M., Fraczek, J., Tabęcka-Łonczyńska, A., & Koziorowski, M. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01557-5 · Cited by 24
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Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B. T., Celano, S. L., Green, J. J., Imus, N. M., Marckini, N., Daley, B. F., Steece‐Collier, K., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.262 · Cited by 23
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Cong, W., Chadwick, W., Wang, R., Daimon, C. M., Cai, H., Amma, J., Wood, W. H., Becker, K. G., Martin, B., & Maudsley, S. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588608 · Cited by 22
Affective Disorder and Epilepsy Comorbidity: Implications for Development of Treatments, Preventions and Diagnostic Approaches
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Authors: Xu, H., Steven Richardson, J., & Li, X.-M.
Affiliations: University of Saskatchewan (CA)
ORCID: Xu, Haiyun
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2003-01
Volume: 28
Issue: 1
Pages: 53-62
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300009
OpenAlex: W2070554778
Cited by: 167
References: 60
Citations by year: 2026: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 10
FWCI: 7.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Psychiatric Research Foundation
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: antidepressants, neuroprotection, hippocampal neurons, amitriptyline, venlafaxine, brain-derived neurotrophic factor, Bcl-2, copper-zinc superoxide dismutase, dose-dependent effects, chronic drug administration, mossy fibers, dentate gyrus
MeSH terms: Venlafaxine Hydrochloride, Amitriptyline, Animals, Antidepressive Agents, Antidepressive Agents, Tricyclic, Cyclohexanols, Densitometry, Dose-Response Relationship, Drug, Hippocampus, Immunohistochemistry, Male, Superoxide Dismutase, Weight Gain, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Proto-Oncogene Proteins c-bcl-2, Rats

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Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

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