Effects of antidepressants on mRNA levels of antioxidant enzymes in human monocytic U-937 cells
Abstract
Alterations of antioxidant enzyme activities have been described in a number of psychiatric disorders including major depression. Subsequently, the present study examined the effects of different types of antidepressants (desipramine, imipramine, maprotiline and mirtazapine) in different concentrations (10(-5), 10(-6) and 10(-7) M) on the mRNA levels of various enzymes of the antioxidant system, including both intracellular superoxide dismutase isoforms, glutathione peroxidase and catalase as well as several enzymes of the glutathione metabolism in monocytic U-937 cells after short- and long-term treatment (2.5 and 24 h) via RT-PCR. Results indicated mainly short-term decreases in the mRNA levels of antioxidant enzymes after treatment with these substances in all the concentrations used. In addition, after long-term treatment, significant increases in the mRNA levels were seen in the cases of Cu, Zn superoxide dismutase, gamma-glutamyl-cysteine synthetase, glutathione-S-transferase and glutathione reductase, including the impacts of all the antidepressants used in concentrations of 10(-6) M and 10(-7) M. Based on the large number of significant effects of all types of antidepressants tested on various antioxidant enzymes, we suggest that antioxidant enzymes may represent important targets in the course of antidepressive treatment.
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The effects of these antidepressants on the expression of antioxidant enzymes are dependent on the duration of the treatment regimen.
“These results suggest that the effects of these antidepressants on the expression of antioxidant enzymes are dependent on the duration of the treatment regimen.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [12]
Short-term treatment with desipramine, imipramine, maprotiline and mirtazapine decreases mRNA levels of SOD and CAT in human monocytic U-937 cells.
“short-term treatment with these drugs decreased mRNA levels of SOD and CAT.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [12]
Long-term treatment with desipramine, imipramine, maprotiline and mirtazapine increases mRNA levels of SOD, GST, and GR in human monocytic U-937 cells.
“However, long-term treatment increased mRNA levels of SOD, GST, and GR.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [12]
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- Authors
- Schmidt, A. J., Heiser, P., Hemmeter, U. M., Krieg, J.-C., & Vedder, H.
- Affiliations
- Philipps University of Marburg (DE)
- University of Freiburg (DE)
- Corresponding author
- Schmidt, Andreas Johannes
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 32
- Issue
- 6
- Pages
- 1567-1573
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2064519572
- Cited by
- 40
- References
- 36
- Citations by year
- 2024: 3 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- antidepressants, antioxidant enzymes, mRNA expression, U937 cells, superoxide dismutase, glutathione peroxidase, catalase, glutathione metabolism, desipramine, imipramine, maprotiline, mirtazapine, major depressive disorder, oxidative stress
- MeSH terms
- Antidepressive Agents, Antidepressive Agents, Tricyclic, Antioxidants, Catalase, Glutathione, Humans, RNA, Messenger, Superoxide Dismutase, Selective Serotonin Reuptake Inhibitors, Adrenergic Uptake Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, U937 Cells
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