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Cited by 19Coffee research and impactsPharmacological Effects and Toxicity StudiesPrenatal Substance Exposure Effects

Caffeine intake in pregnancy: relationship between internal intake and effect on birth weight

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Partosch, F., Mielke, H., Stahlmann, R., Gundert-Remy, U.·2015·Food and Chemical Toxicology
DOI 10.1016/j.fct.2015.11.005
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Abstract

We used a physiologically based kinetic model to simulate caffeine blood concentration-time profiles in non-pregnant and pregnant women. The model predicted concentration-time profile was in good accordance with experimental values. With 200 mg, the safe dose per occasion in non-pregnant women, AUC and peak concentration in pregnant women were nearly twice that of non-pregnant women. In order to derive a safe dose for the pregnant women we estimated the dose in the pregnant women model taken at once which would not exceed AUC and peak concentration in the non-pregnant women of 200 mg as single dose. The resulting dose is 100 mg caffeine per occasion which we recommend as safe. The caffeine dose of 200 mg per day is declared as safe for pregnant women with respect to the foetus by EFSA based on results on reduced birth weight in epidemiological studies. We modelled AUC and peak concentration for different caffeine doses to investigate the relationship between internal caffeine exposure and risk measures of reduced birth weight from epidemiological studies. The graphical analysis revealed that the reduction in birth weight was related to AUC and peak concentration up to a dose of 250 mg caffeine.

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  • Reduced caffeine metabolism in the fetus results in a longer half-life and increased caffeine exposure to the fetus.

    “This reduced caffeine metabolism results in a longer half-life and increased caffeine exposure to the fetus (141, 167).”

    From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [141]

  • Several studies have reported a significant negative association between maternal caffeine consumption and birth weight.

    “Several studies have reported a significant negative association between maternal caffeine consumption and birth weight (84, 85, 140–142).”

    From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [141]

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Authors
Partosch, F., Mielke, H., Stahlmann, R., & Gundert-Remy, U.
Affiliations
  • Stiftung Charité (DE)
  • German Federal Institute for Risk Assessment (BfR) (DE)
Corresponding author
Partosch, F.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2015-12
Volume
86
Pages
291-297
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2015.11.005
OpenAlex
W2111201263
Cited by
19
References
37
Citations by year
2023: 1 · 2022: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 1
FWCI
2.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • OpenAgrar (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
caffeine consumption, pregnancy, birth weight, caffeine pharmacokinetics, physiologically based kinetic modeling, dose-response relationship, internal radiation exposure, AUC, peak concentration
MeSH terms
Adult, Birth Weight, Caffeine, Computer Simulation, Female, Humans, Infant, Newborn, Models, Biological, Pregnancy

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