The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice
Abstract
A hyperdopaminergic state in humans has been hypothesized to contribute to the pathology of a number of psychiatric illnesses, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. Mice that display elevated synaptic levels of dopamine due to a genetically engineered deletion of the dopamine transporter (DAT) model behavioral deficits that simulate the above conditions. As novel treatment strategies for these disorders have focused on the serotonin (5-HT) 2A receptor, we determined the capacity of the highly selective 5-HT(2A) receptor antagonist M100907 to reverse behavioral deficits in DAT knockout (KO) mice. Prior to drug treatment, DAT KO mice exhibited increased levels of locomotor activity and highly linearized movement in a novel environment, as well as reduced prepulse inhibition (PPI) of acoustic startle, compared to wild-type littermates. Treatment with M100907 (0.3-1.0 mg/kg, but not 0.1 mg/kg) reversed locomotor deficits in DAT KO mice. Similarly, treatment with 1.0 mg/kg M100907 reversed the PPI deficits in DAT KO mice. These data indicate that selective 5-HT(2A) receptor antagonists, such as M100907, may represent a class of drugs that can be used to treat conditions in which a chronic, elevated dopaminergic tone is present and contributes to abnormal behavior and sensorimotor gating deficits.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [375]
Citations
Cites
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Self-citationMolecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,898
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701
Self-citationGeyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484
Self-citationHoffman, H. S., & Ison, J. R. (1980) · Psychological Review · doi:10.1037/0033-295x.87.2.175 · Cited by 780
The Role of Serotonin in Antipsychotic Drug Action
Meltzer, H. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00046-9 · Cited by 672
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 626
Self-citationJakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536
Serotonin model of schizophrenia: emerging role of glutamate mechanisms
Aghajanian, G. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00046-6 · Cited by 529
Aghajanian, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00135-3 · Cited by 371
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–104 of 104
Animal models of Gilles de la Tourette Syndrome and other tic disorders
Loewenstern, Y., Tahary, O., Bar‐Gad, I., & Belelovsky, K. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-13554-5.00015-8
Bouchatta, O. (2018) · theses.fr (ABES) · doi:10.70675/5acdd85dz1833z429eza36az308928086d39
Li, H., Zhuo, L., Liu, R., Liao, J., Huang, M., Xiong, X., Lu, S., Zhao, Y., & Wang, L. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116488
Metadata
- Authors
- Barr, A. M., Lehmann-Masten, V., Paulus, M., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A.
- Affiliations
- Scripps Research Institute (US)
- University of California San Diego (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Geyer, Mark A
- Venue
- Neuropsychopharmacology
- Published
- 2003-11-05
- Volume
- 29
- Issue
- 2
- Pages
- 221-228
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2123933616
- Cited by
- 103
- References
- 56
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health (MH60451, MH61326, R01MH061326, P50MH060451)
- National Institute on Drug Abuse (DA 02925, R01DA002925)
- NIH Clinical Center
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- M100907, 5-HT2A receptor antagonist, dopamine transporter knockout mice, hyperdopaminergic state, prepulse inhibition, sensorimotor gating, locomotor activity, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Mental Disorders, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Fluorobenzenes, Inhibition, Psychological, Locomotion, Membrane Glycoproteins, Nerve Tissue Proteins, Piperidines, Reflex, Acoustic, Reversal Learning, Spatial Behavior, Mice, Knockout, Gait Disorders, Neurologic, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Serotonin 5-HT2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
