Cited by 254Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsMental Health and Psychiatry

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Steen, R Grant, Hamer, Robert M, Lieberman, Jeffrey A·2005·Neuropsychopharmacology

Open this paper in CoChat — free account

Abstract

A systematic review of the literature identified 64 published English-language papers that used proton (1H) magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) concurrently in healthy controls and in patients with a diagnosis of schizophrenia (SZ). A total of 1209 controls and 1256 patients have been evaluated, with 88% of studies carried out at 1.5 T field strength, and 77% of studies focused on patients with chronic SZ. There is consistent evidence that NAA is reduced in a broad range of tissues in the SZ brain. Broad consensus (> or =10 studies) is emerging that NAA levels are reduced > or =5% in hippocampus and in both cortical gray matter (GM) and white matter (WM) of the frontal lobe. There is no evidence to support a hypothesis that relative NAA levels are reduced to a different degree in frontal lobe GM and WM, nor is there robust evidence of a difference in NAA levels between patients with first-episode and chronic SZ. Study reliability may be a problem, as most studies appear to be underpowered. With simple assumptions about the inherent difference in NAA levels between patients and controls, it can be calculated that a minimum sample size of approximately 39 patients and 39 controls is required for acceptable statistical power. Only three of 64 studies included enough subjects to have 80% power to detect a 10% NAA reduction in patients, and no studies were adequately powered to detect a 5% NAA reduction with 80% power.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300850

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
Birken, D. L., & Oldendorf, W. H. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80048-x · Cited by 783
Reversible decreases in N‐acetylaspartate after acute brain injury
Stefano, N. D., Matthews, P. M., & Arnold, D. L. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340511 · Cited by 441
Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers.
Théberge, J., Bartha, R., Drost, D., Menon, R. S., Malla, A., Takhar, J., Neufeld, R., Rogers, J., Pavlosky, W., Schaefer, B., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1944 · Cited by 431
Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens.
Dowling, C., Bollen, A. W., Noworolski, S. M., McDermott, M. W., Barbaro, N. M., Day, M. R., Henry, R. G., Chang, S. M., Dillon, W. P., Nelson, S. J., et al. (2001) · PubMed Central · Cited by 378
Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Medicated Patients With Chronic Schizophrenia and Healthy Comparison Subjects Measured With 4.0-T Proton MRS
Théberge, J., Al-Semaan, Y. M., Williamson, P., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., Schaefer, B., Densmore, M., & Drost, D. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2231 · Cited by 269
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging
Bertolino, A., Nawroz, S., Mattay, V. S., Barnett, A. S., Duyn, J. H., MOONEN, C. T. W., Frank, J. A., Tedeschi, G., & Weinberger, D. R. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1554 · Cited by 256
Magnetic resonance spectroscopy in AD
Valenzuela, M., & Sachdev, P. S. (2001) · Neurology · doi:10.1212/wnl.56.5.592 · Cited by 256
Measurement of Glutamate and Glutamine in the Medial Prefrontal Cortex of Never-Treated Schizophrenic Patients and Healthy Controls by Proton Magnetic Resonance Spectroscopy
Bartha, R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220085012 · Cited by 230
The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis
Tartaglia, M. C., Narayanan, S., Francis, S. J., dos Santos, A. C., Stefano, N. D., Lapierre, Y., & Arnold, D. L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.2.201 · Cited by 207

Flagged first, then by citations

Show all 107 references

Sorted by citations

Items 101–200 of 254

Antipsychotic drugs increase N‐acetylaspartate and N‐acetylaspartylglutamate in SH‐SY5Y human neuroblastoma cells
Arun, P., Madhavarao, C. N., Moffett, J. R., & Namboodiri, A. M. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05524.x · Cited by 34
Single‐voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus
Venkatraman, T. N., Hamer, R. M., Perkins, D. O., Song, A. W., Lieberman, J. A., & Steen, R. G. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1055 · Cited by 35
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users
Stone, J. M., Pepper, F., Fam, J., Furby, H., Hughes, E., Morgan, C. J. A., & Howes, O. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3354-8 · Cited by 34
Single‐voxel 1 H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility
Allaïli, N., Valabrègue, R., Auerbach, E. J., Guillemot, V., Yahia‐Cherif, L., Bardinet, É., Jabourian, M., Fossati, P., Lehéricy, S., & Marjańska, M. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3364 · Cited by 36
The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models
Tendilla‐Beltrán, H., Sanchez-Islas, N. D. C., Marina-Ramos, M., Leza, J. C., & Flores, G. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101967 · Cited by 36
MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
Tunc‐Skarka, N., Weber‐Fahr, W., Hoerst, M., Meyer‐Lindenberg, A., Zink, M., & Ende, G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.061 · Cited by 34
3‐T proton magnetic spectroscopy in unmedicated first episode psychosis: A focus on creatine
Tibbo, P. G., Bernier, D. C., Hanstock, C. C., Seres, P., Lakusta, B., & Purdon, S. E. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24291 · Cited by 33
Synapse pathology and translational applications for schizophrenia
Hayashi‐Takagi, A. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.09.001 · Cited by 32
1H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia
Uhl, I., Mavrogiorgou, P., Norra, C., Forstreuter, F., Scheel, M., Witthaus, H., Özgürdal, S., Gudlowski, Y., Böhner, G., Gallinat, J., et al. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.02.004 · Cited by 33
Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic 1NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia
Strzelecki, D., Podgórski, M. T., Kałużyńska, O., Gawlik-Kotelnicka, O., Stefańczyk, L., Kotlicka‐Antczak, M., Gmitrowicz, A., & Grzelak, P. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.039 · Cited by 32
Metabolic Alterations in the Amygdala in Borderline Personality Disorder: A Proton Magnetic Resonance Spectroscopy Study
Hoerst, M., Weber‐Fahr, W., Tunc‐Skarka, N., Ruf, M., Bohus, M., Schmahl, C. G., & Ende, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.030 · Cited by 32
Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: A proton magnetic resonance spectroscopy study
Atagün, M. İ., Şıkoğlu, E. M., Can, S. S., Karakaş-Uğurlu, G., Ulusoy-Kaymak, S., Çayköylü, A., Algın, O., Phillips, M. L., Moore, C. M., & Öngür, D. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.11.012 · Cited by 33
Supplementation of Antipsychotic Treatment with the Amino Acid Sarcosine Influences Proton Magnetic Resonance Spectroscopy Parameters in Left Frontal White Matter in Patients with Schizophrenia
Strzelecki, D., Podgórski, M. T., Kałużyńska, O., Gawlik-Kotelnicka, O., Stefańczyk, L., Kotlicka‐Antczak, M., Gmitrowicz, A., & Grzelak, P. (2015) · Nutrients · doi:10.3390/nu7105427 · Cited by 32
Angiogenesis in the pathophysiology of schizophrenia — A comprehensive review and a conceptual hypothesis
Lopes, R., Soares, R. A., Coelho, R. C., & Figueiredo‐Braga, M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.02.010 · Cited by 32
Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia
Seese, R. R., O’Neill, J., Hudkins, M. R., Siddarth, P., Levitt, J. G., Tseng, B., Wu, K. N., & Caplan, R. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.07.011 · Cited by 30
Proton magnetic resonance spectroscopy measures related to short-term symptomatic outcome in chronic schizophrenia
Szulc, A., Konarzewska, B., Galińska-Skok, B., Lazarczyk, J., Waszkiewicz, N., Tarasów, E., Milewski, R. J., & Walecki, J. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.051 · Cited by 29
Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a 1[H]-spectroscopy twin study
Legind, C. S., Broberg, B. V., Mandl, R. C. W., Brouwer, R. M., Anhøj, S. J., Hilker, R. W., Jensen, M. H., McGuire, P. K., Pol, H. E. H., Fagerlund, B., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0236-0 · Cited by 29
Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
Malchow, B., Hasan, A., Schneider-Axmann, T., Jatzko, A., Gruber, O., Schmitt, A., Falkai, P., & Wobrock, T. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0451-y · Cited by 30
Findings of proton magnetic resonance spectometry in the dorsolateral prefrontal cortex in adolescents with first episodes of psychosis
Zabala, A., Sánchez‐Gonzalez, J., Parellada, M., Moreno, D. M., Reig, S., Burdalo, M. T., Robles, O., Desco, M., & Arango, C. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.12.016 · Cited by 29
Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and 1H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review
Piersson, A. D., Mohamad, M., Rajab, F., & Suppiah, S. (2020) · Academic Radiology · doi:10.1016/j.acra.2020.06.006 · Cited by 28
Comparison of brain N-acetylaspartate levels and serum brain-derived neurotrophic factor (BDNF) levels between patients with first-episode schizophrenia psychosis and healthy controls
Gotō, N., Yoshimura, R., Kakeda, S., Moriya, J., Hayashi, K., Ikenouchi, A., Umene‐Nakano, W., Hori, H., Ueda, N., Korogi, Y., et al. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2009.10.001 · Cited by 28
Developing New Drugs for Schizophrenia: From Animals to the Clinic
Jones, D. N. C., Gartlon, J. E., Minassian, A., Perry, W., & Geyer, M. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00008-4 · Cited by 30
Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study
Matarín, M., Pueyo, R., Poca, M. A., Falcón, C., Mataró, M., Bargalló, N., Sahuquillo, J., & Junqué, C. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.088450 · Cited by 27
Evidence for regional hippocampal damage in patients with schizophrenia
Singh, S., Khushu, S., Kumar, P., Goyal, S., Triptish Bhatia, A., & Deshpande, S. N. (2017) · Neuroradiology · doi:10.1007/s00234-017-1954-4 · Cited by 27
Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex
Strzelecki, D., Podgórski, M. T., Kałużyńska, O., Stefańczyk, L., Kotlicka‐Antczak, M., Gmitrowicz, A., & Grzelak, P. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024475 · Cited by 27
MR spectroscopy in schizophrenia
Port, J. D., & Agarwal, N. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22787 · Cited by 25
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder
Biria, M., Cantonas, L.-M., & Banca, P. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_201 · Cited by 27
Spectroscopic metabolomic abnormalities in the thalamus related to auditory hallucinations in patients with schizophrenia
Martínez-Granados, B., Brotons, O., Martínez‐Bisbal, M. C., Celda, B., Martí‐Bonmatí, L., Aguilar, E. J., González, J. C., & Sanjuán, J. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.05.025 · Cited by 26
Altered 13 C Glucose Metabolism in the Cortico—Striato—Thalamo—Cortical Loop in the MK-801 Rat Model of Schizophrenia
Eyjolfsson, E. M., Nilsen, L. H., Kondziella, D., Brenner, E., Haberg, A. K., & Sonnewald, U. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.193 · Cited by 25
Altered Reward Circuitry in the Norepinephrine Transporter Knockout Mouse
Gallagher, J. J., Zhang, X., Hall, F. S., Uhl, G. R., Bearer, E. L., & Jacobs, R. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057597 · Cited by 25
Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands
Capizzano, A. A., Toscano, J. L. N., & Ho, B. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.024 · Cited by 24
Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: A potential new tool for diagnosis
Shi, X.-F., Forrest, L. N., Kuykendall, M. D., Prescot, A. P., Sung, Y., Huber, R. S., Hellem, T., Jeong, E., Renshaw, P. F., & Kondo, D. G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.051 · Cited by 25
Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection
Aydın, K., Ucok, A., & Cakir, S. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0691 · Cited by 25
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status
Yang, Y. S., Smucny, J., Zhang, H., & Maddock, R. J. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103461 · Cited by 23
Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia
Nenadić, I., Maitra, R., Basu, S., Dietzek, M., Schönfeld, N., Lorenz, C., Gussew, A., Amminger, G. P., McGorry, P. D., Reichenbach, J. R., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.05.005 · Cited by 24
Magnetic resonance spectroscopy investigations of functionally defined language areas in schizophrenia patients with and without auditory hallucinations
Homan, P., Vermathen, P., van Swam, C., Federspiel, A., Boesch, C., Strik, W. K., Dierks, T., Hubl, D., & Kreis, R. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.009 · Cited by 23
Biochemical changes in the cingulum in patients with schizophrenia and chronic bipolar disorder
Crespo, F. S., Luque, R., Prieto‐Merino, D., Sau, P., Albert, C., Leal, I., de Luxan, A., Osuna, M. I., Ruiz, M., Galán, R., et al. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0808-9 · Cited by 23
Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia
Reid, M. A., Kraguljac, N. V., Avsar, K. B., White, D. M., den Hollander, J. A., & Lahti, A. C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.036 · Cited by 22
Systematic Review of the Neural Effect of Electroconvulsive Therapy in Patients with Schizophrenia: Hippocampus and Insula as the Key Regions of Modulation
Moon, S.-Y., Kim, M., Lho, S. K., Oh, S., Kim, S. H., & Kwon, J. S. (2021) · Psychiatry Investigation · doi:10.30773/pi.2020.0438 · Cited by 22
Imaging genetics of structural brain connectivity and neural integrity markers
Marenco, S., & Radulescu, E. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.030 · Cited by 22
Comparison of Inter Subject Variability and Reproducibility of Whole Brain Proton Spectroscopy
Veenith, T., Mada, M., Carter, E., Grossac, J., Newcombe, V., Outtrim, J. G., Lupson, V. C., Nallapareddy, S., Williams, G. B., Sheriff, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115304 · Cited by 22
N-Acetyl-Aspartate Level is Decreased in the Prefrontal Cortex in Subjects At-Risk for Schizophrenia
Mondino, M., Brunelin, J., & Saoud, M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00099 · Cited by 22
Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review
Garcia, G. J., Chagas, M. H. N., Silva, C. H., Machado‐de‐Sousa, J. P., Crippa, J. A. S., & Hallak, J. E. C. (2015) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2014-1387 · Cited by 22
Medial-frontal cortex hypometabolism in chronic phencyclidine exposed rats assessed by high resolution magic angle spin 11.7T proton magnetic resonance spectroscopy
Bustillo, J., Galloway, M. P., Ghoddoussi, F., Bolognani, F., & Perrone‐Bizzozero, N. I. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.04.003 · Cited by 20
Mitochondrial Involvement in Mental Disorders: Energy Metabolism and Genetic and Environmental Factors
Iwata, K. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_3 · Cited by 20
T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia
Bracken, B. K., Rouse, E. D., Renshaw, P. F., & Olson, D. P. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.03.005 · Cited by 20
Brain Functional Effects of Psychopharmacological Treatments in Schizophrenia: A Network-based Functional Perspective Beyond Neurotransmitter Systems
Rossi, P. D., Chiapponi, C., & Spalletta, G. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150507223542 · Cited by 19
Neuroprotective Effect of Modified Electroconvulsive Therapy for Schizophrenia
Gan, J., Duan, H.-F., Cheng, Z., Yang, J.-M., Zhu, X.-Q., Cun-you, G., Lan-min, Z., & Liang, X. (2017) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000652 · Cited by 19
N-Acetyl-Aspartate in the dorsolateral prefrontal cortex in men with schizophrenia and auditory verbal hallucinations: A 1.5 T Magnetic Resonance Spectroscopy Study
Psomiades, M., Mondino, M., Fonteneau, C., Bation, R., Haesebaert, F., Suaud‐Chagny, M., & Brunelin, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22597-y · Cited by 19
Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study
Galińska-Skok, B., Małus, A., Konarzewska, B., Rogowska-Zach, A., Milewski, R. J., Tarasów, E., Szulc, A., & Waszkiewicz, N. (2018) · Disease Markers · doi:10.1155/2018/3654894 · Cited by 19
Cerebral Metabolic Alterations in McLeod Syndrome
Dydak, U., Mueller, S. G., Sándor, P. S., Meier, D., Boesiger, P., & Jung, H. H. (2006) · European Neurology · doi:10.1159/000095136 · Cited by 18
Concurrent changes in 1H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: Possible implications for schizophrenia
Xuan, Y., Yan, G., Peng, H., Wu, R., & Xu, H. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.02.004 · Cited by 17
Detection of Glutamate Alterations in the Human Brain Using 1H-MRS: Comparison of STEAM and sLASER at 7 T
Marsman, A., Boer, V. O., Luijten, P. R., Pol, H. E. H., Klomp, D. W. J., & Mandl, R. C. W. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00060 · Cited by 17
N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects
Kuan, E., Chen, X., Du, F., & Öngür, D. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.04.012 · Cited by 16
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice
Matsumoto, Y., Niwa, M., Mouri, A., Noda, Y., Fukushima, T., Ozaki, N., & Nabeshima, T. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4704-8 · Cited by 15
Brain metabolite concentrations across cortical regions in healthy adults
Bracken, B. K., Jensen, J. E., Prescot, A. P., Cohen, B. M., Renshaw, P. F., & Öngür, D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.036 · Cited by 15
Readdressing synaptic pruning theory for schizophrenia
Hayashi‐Takagi, A., Barker, P. B., & Arika, S. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.2.14492 · Cited by 15
Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Smucny, J., Carter, C. S., & Maddock, R. J. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.10.008 · Cited by 14
Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first‐episode treatment‐naïve schizophrenia patients
He, Z., Deng, W., Li, M., Chen, Z., Collier, D. A., Ma, X., & Li, T. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00291.x · Cited by 14
An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth
Joe, P., Clemente, J. C., Piras, E., Wallach, D. S., Robinson‐Papp, J., Boka, E., Remsen, B., Bonner, M., Kimhy, D., Goetz, D. M., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.09.019 · Cited by 14
Modular Functional-Metabolic Coupling Alterations of Frontoparietal Network in Schizophrenia Patients
Xiang, Q., Xu, J., Wang, Y., Chen, T., Wang, J., Zhuo, K., Guo, X., Zeljic, K., Li, W., Sun, Y., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00040 · Cited by 15
Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy
Lewandowski, K. E., Du, F., Fan, X., Chen, X., Huynh, P., & Öngür, D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.05.018 · Cited by 13
A Review of MR Spectroscopy Studies of Pediatric Bipolar Disorder
Kondo, D. G., Hellem, T., Shi, X., Sung, Y. H., Prescot, A. P., Kim, T.-E., Huber, R. S., Forrest, L. N., & Renshaw, P. F. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3844 · Cited by 13
Increased thalamic phospholipid concentration evident in bipolar I disorder
Howells, F. M., Ives-Deliperi, V. L., Horn, N. R., & Stein, D. J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.026 · Cited by 13
Decreased frontal lobe function in people with Internet addiction disorder.
Liu, J., Esmail, F., Li, L., Kou, Z., Li, W.-H., Gao, X., Wang, Z., Tan, C., Zhang, Y., & Zhou, S. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.34.006 · Cited by 12
Relationship between frontal N-acetylaspartate and cognitive deficits in first-episode schizophrenia.
Galińska-Skok, B., Szulc, A., Tarasów, E., Kubas, B., Dzienis, W., Siergiejczyk, L., Czernikiewicz, A., & Walecki, J. M. (2007) · PubMed · Cited by 12
Magnetic resonance imaging and spectroscopy: how useful is it for prediction and prognosis?
Condon, B. R. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0086-x · Cited by 12
Incremento del glutamato en el estriado de asociación en esquizofrenia. Resultados preliminares de un estudio longitudinal con espectroscopia con resonancia magnética
de la Fuente‐Sandoval, C., Favila, R., Alvarado, P., León-Ortíz, P., Díaz-Galvis, L., Amezcua, C., García-Muñoz, E., & Graff‐Guerrero, A. (2009) · Gaceta Médica de México · Cited by 12
Metabolic Changes in the Visual Cortex of Binocular Blindness Macaque Monkeys: A Proton Magnetic Resonance Spectroscopy Study
Wu, L., Tang, Z., Sun, X., Feng, X., Qian, W., Wang, J., & Jin, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080073 · Cited by 12
The predictive value of baseline NAA/Cr for treatment response of first-episode schizophrenia: A 1H MRS study
Liu, W., Yu, H., Jiang, B., Pan, B., Yu, S., Li, H., & Zheng, L. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.06.029 · Cited by 13
Mitochondria, Oxidative Stress, and Psychiatric Disorders: An Integrative Perspective on Brain Bioenergetics
Nunes, P. I. G., Benjamin, S. R., Brito, R. D. S., de Aguiar, M. R., Neves, L. B., & de Bruin, V. M. S. (2025) · Clinical bioenergetics · doi:10.3390/clinbioenerg1010006 · Cited by 13
Limbic hyperactivity associated to verbal memory deficit in schizophrenia
Suazo, V., Díez, Á., Tamayo, P., Montes, C., & Molina, V. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.007 · Cited by 10
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: An in vivo magnetic resonance spectroscopy study
Lindquist, D. M., Dunn, R. S., & Cecil, K. M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.02.019 · Cited by 10
SNAP-25 genotype influences NAA/Cho in left hippocampus
Scherk, H., Backens, M., Zill, P., Schneider-Axmann, T., Wobrock, T., Usher, J., Reith, W., Falkai, P., Möller, H., Bondy, B., et al. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0103-y · Cited by 10
Proton magnetic resonance spectroscopy of the frontal, cingulate and perirolandic cortices and its relationship to skin conductance in patients with schizophrenia
Sanches, R. F., Crippa, J. A. S., Hallak, J. E. C., de Sousa, J. P. M., Araújo, D., dos Santos, A. C., & Zuardi, A. W. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008001200015 · Cited by 10
The relationship between the alterations in metabolite levels in the dorsolateral prefrontal cortex and clinical symptoms of patients with first-episode schizophrenia: a one year follow-up study
Huang, M., Guo, W., Lu, S., Pan, F., Chen, J., Hu, J., Hu, S., Xu, W., Shang, D., & Xu, Y. (2018) · Oncotarget · doi:10.18632/oncotarget.23983 · Cited by 9
Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic, and Environmental Factors
Iwata, K. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8994-2_2 · Cited by 9
Multimodal neuroimaging of frontal white matter microstructure in early phase schizophrenia: the impact of early adolescent cannabis use
Bernier, D. C., Cookey, J., McAllindon, D. P., Bartha, R., Hanstock, C. C., Newman, A. J., Stewart, S. H., & Tibbo, P. G. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-264 · Cited by 9
Effects of normal aging and SCN1A risk‐gene expression on brain metabolites: evidence for an association between SCN1A and myo‐inositol
Tunc‐Skarka, N., Meier, S., Demirakça, T., Sack, M., Weber‐Fahr, W., Brusniak, W., Wolf, I., Matthäus, F., Schulze, T. G., Diener, C., et al. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3057 · Cited by 8
Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives
Roberts, D., Rösler, L., Wijnen, J. P., & Thakkar, K. N. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111612 · Cited by 8
An overview of functional, structural and neurochemical imaging studies in individuals with a clinical high risk for psychosis
Egerton, A., Borgwardt, S., Tognin, S., Howes, O. D., McGuire, P. K., & Allen, P. (2011) · Neuropsychiatry · doi:10.2217/npy.11.51 · Cited by 8
Anatomical, functional and molecular biomarker applications of magnetic resonance neuroimaging
Liu, C. H. (2015) · Future Neurology · doi:10.2217/fnl.14.60 · Cited by 8
N-Acetylaspartate Metabolism Underlays the Structural and Functional Units of the Vertebrate Brain: A Bioenergetic Rationale for Clinical Observations of Changes in the Neuronal Biomarker “NAA” in many Human Brain Disorders
Baslow, M. H., & Burlina, A. P. (2012) · Bioenergetics Open access · doi:10.4172/2167-7662.1000102 · Cited by 8
Alterations of neurometabolism in the dorsolateral prefrontal cortex and thalamus in transition to psychosis patients change under treatment as usual – A two years follow-up 1H/31P-MR-spectroscopy study
Smesny, S., Berberich, D., Gussew, A., Schönfeld, N., Langbein, K., Walther, M., & Reichenbach, J. R. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2020.11.063 · Cited by 7
Association between prefrontal N-acetylaspartate and insight in psychotic disorders
Larabi, D. I., Liemburg, E. J., Pijnenborg, G. H. M., Sibeijn‐Kuiper, A., de Vos, A. E., Bais, L., Knegtering, H., Ćurĉić‐Blake, B., & Aleman, A. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.09.018 · Cited by 7
Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia
Hong, C., Liou, Y., Liao, D., Hou, S.-J., Yen, F.-C., & Tsai, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.010 · Cited by 7
1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients
Kırtaş, D., KARADAĞ, R. F., Şengül, M. C. B., & Kıroğlu, Y. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1502-9 · Cited by 7
31P-MR spectroscopy in monozygotic twins discordant for schizophrenia or schizoaffective disorder
Nenadić, I., Langbein, K., Weisbrod, M., Maitra, R., Rzanny, R., Gussew, A., Reichenbach, J. R., Sauer, H., & Smesny, S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.008 · Cited by 6
Psychiatric diseases
Radaelli, D., Bernasconi, A., & Benedetti, F. (2008) · Neurological Sciences · doi:10.1007/s10072-008-1012-4 · Cited by 6
The Effect of Aripiprazole versus Risperidone on Prefrontal Brain Metabolite Levels and Brain Volume in Psychotic Disorders: An Exploratory Study
Liemburg, E. J., Sibeijn‐Kuiper, A., Knegtering, H., & Aleman, A. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000339 · Cited by 5
Basal glutamate in the hippocampus and the dorsolateral prefrontal cortex in schizophrenia: Relationships to cognitive proficiency investigated with structural equation modelling
Stanley, J. A., Daugherty, A. M., Gorey, C. L. R., Thomas, P., Khatib, D., Chowdury, A., Rajan, U., Haddad, L., Amirsadri, A., & Diwadkar, V. A. (2023) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2023.2197653 · Cited by 4
Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment
Iwata, K., Noguchi, M., & Shintani, N. (2025) · Biomolecules · doi:10.3390/biom15020184 · Cited by 6
Imagerie cérébrale en psychiatrie : indications et résultats
Orliac, F., & Delamillieure, P. (2012) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(12)60525-2 · Cited by 6
Neuroimaging studies in schizophrenia: An overview of research from Asia
Narayanaswamy, J. C., Venkatasubramanian, G., & Gangadhar, B. N. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.704872 · Cited by 4
MRI in Animal Models of Psychiatric Disorders
Poole, D. S., Oitzl, M. S., & van der Weerd, L. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-219-9_17 · Cited by 4
Spectroscopic imaging of schizophrenia
Pettegrew, J. W., McClure, R. J., & Panchalingam, K. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782091.004 · Cited by 3
Comparison of Metabolite Concentrations in the Left Dorsolateral Prefrontal Cortex, the Left Frontal White Matter, and the Left Hippocampus in Patients in Stable Schizophrenia Treated with Antipsychotics with or without Antidepressants. 1H-NMR Spectroscopy Study
Strzelecki, D., Grzelak, P., Podgórski, M. T., Kałużyńska, O., Stefańczyk, L., Kotlicka‐Antczak, M., & Gmitrowicz, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024387 · Cited by 3
NPAS3 variants in schizophrenia: a neuroimaging study
Bernier, D. C., MacIntyre, G., Bartha, R., Hanstock, C. C., McAllindon, D. P., Cox, D. W., Purdon, S. E., Aitchison, K. J., Rusak, B., & Tibbo, P. G. (2014) · BMC Medical Genetics · doi:10.1186/1471-2350-15-37 · Cited by 3
Glutamatergic mechanisms in schizophrenia: Current concepts
Beneyto, M., Kristiansen, L. V., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2006) · Current Psychosis & Therapeutics Reports · doi:10.1007/bf02629411 · Cited by 3
Neurobiology and etiology of primary schizophrenia: current status
Keshavan, M. S., & Jindal, R. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511789977.002 · Cited by 3

Authors: Steen, R. G., Hamer, R. M., & Lieberman, J. A.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Steen, R Grant
ORCID: Steen, R Grant
Lieberman, Jeffrey A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-08-10
Volume: 30
Issue: 11
Pages: 1949-1962
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300850
OpenAlex: W1965782412
Cited by: 254
References: 107
Citations by year: 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 16 · 2013: 27 · 2012: 14
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Foundation of Hope for Research and Treatment of Mental Illness
University of North Carolina at Chapel Hill
National Institute of Mental Health (MH-64065, R01MH061603, P50MH064065, MH 61603)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, N-acetylaspartate, brain metabolites, 1H NMR, hippocampus, frontal lobe, cortical gray matter, white matter, chronic schizophrenia, first-episode schizophrenia
MeSH terms: Aspartic Acid, Brain Chemistry, Humans, Magnetic Resonance Spectroscopy, Schizophrenia, Tritium

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks