Cited by 254Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsMental Health and Psychiatry

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Steen, R Grant, Hamer, Robert M, Lieberman, Jeffrey A·2005·Neuropsychopharmacology

Open this paper in CoChat — free account

Abstract

A systematic review of the literature identified 64 published English-language papers that used proton (1H) magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) concurrently in healthy controls and in patients with a diagnosis of schizophrenia (SZ). A total of 1209 controls and 1256 patients have been evaluated, with 88% of studies carried out at 1.5 T field strength, and 77% of studies focused on patients with chronic SZ. There is consistent evidence that NAA is reduced in a broad range of tissues in the SZ brain. Broad consensus (> or =10 studies) is emerging that NAA levels are reduced > or =5% in hippocampus and in both cortical gray matter (GM) and white matter (WM) of the frontal lobe. There is no evidence to support a hypothesis that relative NAA levels are reduced to a different degree in frontal lobe GM and WM, nor is there robust evidence of a difference in NAA levels between patients with first-episode and chronic SZ. Study reliability may be a problem, as most studies appear to be underpowered. With simple assumptions about the inherent difference in NAA levels between patients and controls, it can be calculated that a minimum sample size of approximately 39 patients and 39 controls is required for acceptable statistical power. Only three of 64 studies included enough subjects to have 80% power to detect a 10% NAA reduction in patients, and no studies were adequately powered to detect a 5% NAA reduction with 80% power.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300850

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
Birken, D. L., & Oldendorf, W. H. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80048-x · Cited by 783
Reversible decreases in N‐acetylaspartate after acute brain injury
Stefano, N. D., Matthews, P. M., & Arnold, D. L. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340511 · Cited by 441
Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers.
Théberge, J., Bartha, R., Drost, D., Menon, R. S., Malla, A., Takhar, J., Neufeld, R., Rogers, J., Pavlosky, W., Schaefer, B., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1944 · Cited by 431
Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens.
Dowling, C., Bollen, A. W., Noworolski, S. M., McDermott, M. W., Barbaro, N. M., Day, M. R., Henry, R. G., Chang, S. M., Dillon, W. P., Nelson, S. J., et al. (2001) · PubMed Central · Cited by 378
Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Medicated Patients With Chronic Schizophrenia and Healthy Comparison Subjects Measured With 4.0-T Proton MRS
Théberge, J., Al-Semaan, Y. M., Williamson, P., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., Schaefer, B., Densmore, M., & Drost, D. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2231 · Cited by 269
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging
Bertolino, A., Nawroz, S., Mattay, V. S., Barnett, A. S., Duyn, J. H., MOONEN, C. T. W., Frank, J. A., Tedeschi, G., & Weinberger, D. R. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1554 · Cited by 256
Magnetic resonance spectroscopy in AD
Valenzuela, M., & Sachdev, P. S. (2001) · Neurology · doi:10.1212/wnl.56.5.592 · Cited by 256
Measurement of Glutamate and Glutamine in the Medial Prefrontal Cortex of Never-Treated Schizophrenic Patients and Healthy Controls by Proton Magnetic Resonance Spectroscopy
Bartha, R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220085012 · Cited by 230
The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis
Tartaglia, M. C., Narayanan, S., Francis, S. J., dos Santos, A. C., Stefano, N. D., Lapierre, Y., & Arnold, D. L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.2.201 · Cited by 207
Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study
Bertolino, A., Callicott, J. H., Elman, I., Mattay, V. S., Tedeschi, G., Frank, J. A., Breier, A. F., & Weinberger, D. R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00555-6 · Cited by 198
Reduced brain N ‐acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus‐seropositive individuals
Meyerhoff, D. J., MacKay, S., Bachman, L., Poole, N., Dillon, W. P., Weiner, M. W., & Fein, G. (1993) · Neurology · doi:10.1212/wnl.43.3_part_1.509 · Cited by 197
Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy
Kalra, S., Cashman, N. R., Genge, A. L., & Arnold, D. L. (1998) · Neuroreport · doi:10.1097/00001756-199806010-00016 · Cited by 178
Proton Magnetic Resonance Spectroscopy of the Frontal Lobe and Cerebellar Vermis in Children with a Mood Disorder and a Familial Risk for Bipolar Disorders
Cecil, K. M., DelBello, M. P., Sellars, M. C., & Strakowski, S. M. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603322724931 · Cited by 161
The effect of treatment with antipsychotic drugs on brain N-acetylaspartate measures in patients with schizophrenia
Bertolino, A., Callicott, J. H., Mattay, V. S., Weidenhammer, K. M., Rakow‐Penner, R., Egan, M. F., & Weinberger, D. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00997-5 · Cited by 156
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates
Buckley, P. F., Moore, C. M., Long, H., Larkin, C., Thompson, P. A., Mulvany, F., Redmond, O., Stack, J. P., Ennis, J. T., & Waddington, J. L. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90591-6 · Cited by 152
Specific Relationship Between Prefrontal NeuronalN-Acetylaspartate and Activation of the Working Memory Cortical Network in Schizophrenia
Bertolino, A., Esposito, G., Callicott, J. H., Mattay, V. S., Horn, J. D. V., Frank, J. A., Berman, K. F., & Weinberger, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.26 · Cited by 149
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients
Sharma, R. P., Venkatasubramanian, P. N., Bárány, M., & Davis, J. M. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90059-e · Cited by 148
Asperger Syndrome
Murphy, D., Critchley, H., Schmitz, N., McAlonan, G. M., van Amelsvoort, T., Robertson, D., Daly, E., Rowe, A., Russell, A., Simmons, A., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.885 · Cited by 139
Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls
Steel, R. M., Bastin, M. E., McConnell, S., Marshall, I., Owens, D. G. C., Lawrie, S. M., Johnstone, E. C., & Best, J. J. K. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00080-4 · Cited by 138
N‐Acetyl Aspartate—A Neuronal Marker?
Barker, P. B. (2001) · Annals of Neurology · doi:10.1002/ana.90 · Cited by 132
Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy
Bernasconi, A. (2003) · Brain · doi:10.1093/brain/awg249 · Cited by 132
Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype
Callicott, J. H., Egan, M. F., Bertolino, A., Mattay, V. S., Langheim, F. J. P., Frank, J. A., & Weinberger, D. R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00264-9 · Cited by 131
Use of proton magnetic resonance spectroscopy of the brain to differentiate gliomatosis cerebri from low-grade glioma
Damien Galanaud, E., Chinot, O. L., Nicoli, F., Sylviane Confort-gouny, A., Fur, Y. L., Barrié, M., Ranjeva, J., Fuentes, S., Viout, P., Figarella-Branger, D. F., et al. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.98.2.0269 · Cited by 126
Preoperative brain injury in newborns with transposition of the great arteries
Miller, S. P., McQuillen, P. S., Vigneron, D. B., Glidden, D. V., Barkovich, A. J., Ferriero, D. M., Hamrick, S. E. G., Azakie, A., & Karl, T. R. (2004) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2003.10.084 · Cited by 124
Canavan disease: From spongy degeneration to molecular analysis
Matalon, R. K., Michals, K., & Kaul, R. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70105-2 · Cited by 124
Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease
Dixon, R. M. (2002) · Brain · doi:10.1093/brain/awf226 · Cited by 124
Proton Magnetic Resonance Spectroscopic Imaging of Cortical Gray and White Matter in Schizophrenia
Lim, K. O., Elfar Adalsteinsson, A., Spielman, D. M., Sullivan, E. V., Rosenbloom, M. J., & Pfefferbaum, A. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.4.346 · Cited by 122
Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic Imaging
Bertolino, A., Kumra, S., Callicott, J. H., Mattay, V. S., Lestz, R. M., Jacobsen, L. K., Barnett, L. S., Duyn, J. H., Frank, J. A., Rapoport, J. L., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1376 · Cited by 116
Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study
Guerrini, L. (2004) · Brain · doi:10.1093/brain/awh201 · Cited by 115
Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia
Ende, G., Braus, D. F., Walter, S., Weber‐Fahr, W., Soher, B. J., Maudsley, A. A., & Henn, F. A. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00089-4 · Cited by 114
Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder
Deicken, R. F., Eliaz, Y., Feiwell, R., & Schuff, N. W. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00083-4 · Cited by 113
Clinical correlation of striatal 1H MRS changes in Huntington’s disease
Sánchez‐Pernaute, R., García-Segura, J. M., Alba, A. D. B., Viano, J. C., & de Yébenes, J. G. (1999) · Neurology · doi:10.1212/wnl.53.4.806 · Cited by 113
Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy.
Richards, T. L. (1991) · American Journal of Roentgenology · doi:10.2214/ajr.157.5.1927795 · Cited by 108
Selective Relationship Between Prefrontal N-Acetylaspartate Measures and Negative Symptoms in Schizophrenia
Callicott, J. H., Bertolino, A., Egan, M. F., Mattay, V. S., Langheim, F. J. P., & Weinberger, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1646 · Cited by 108
Proton Magnetic Resonance Spectroscopy (1H MRS) of the Hippocampal Formation in Schizophrenia: A Pilot Study
Nasrallah, H. A., Skinner, T. E., Schmalbrock, P., & Robitaille, P.-M. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.4.481 · Cited by 108
Absence of N‐acetylaspartate in the human brain: Impact on neurospectroscopy?
Martin, E., Capone, A., Schneider, J., Hennig, J., & Thiel, T. (2001) · Annals of Neurology · doi:10.1002/ana.102.abs · Cited by 107
Proton Magnetic Resonance Spectroscopy in the Frontal and Temporal Lobes of Neuroleptic Naive Patients with Schizophrenia
Cecil, K. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00063-3 · Cited by 105
Magnetic resonance spectroscopy: current and future applications in psychiatric research
Lyoo, I. K., & Renshaw, P. F. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01313-0 · Cited by 104
Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia
Maier, M., Ron, M. A., Barker, G. J., & Tofts, P. S. (1995) · Psychological Medicine · doi:10.1017/s0033291700033171 · Cited by 102
Low-Grade Gliomas and Focal Cortical Developmental Malformations: Differentiation with Proton MR Spectroscopy
Vuori, K., Kankaanranta, L., Häkkinen, A., Gaily, E. K., Valanne, L. K., Granström, M., Joensuu, H., Blomstedt, G. C., Paetau, A. E., & Lundbom, N. M. I. (2004) · Radiology · doi:10.1148/radiol.2303021804 · Cited by 99
An In Vivo Proton Magnetic Resonance Spectroscopy Study of Schizophrenia Patients
Stanley, J. A., Williamson, P., Drost, D. J., Rylett, R. J., Carr, T. J., MALLA, A. K., & Thompson, R. T. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.4.597 · Cited by 98
Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation
Auer, D. P., Wilke, M., Grabner, A., Heidenreich, J. O., Bronisch, T., & Wetter, T. C. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00155-4 · Cited by 96
Absence of N‐acetylaspartate in the human brain: Impact on neurospectroscopy?
Martin, E., Capone, A., Schneider, J., Hennig, J., & Thiel, T. (2001) · Annals of Neurology · doi:10.1002/ana.102 · Cited by 94
Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosis
Gadea, M. (2003) · Brain · doi:10.1093/brain/awh002 · Cited by 93
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis
Renshaw, P. F., Yurgelun-Todd, D. A., Tohen, M. F., Gruber, S. A., & Cohen, B. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.444 · Cited by 88
Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies
Kegeles, L. S., Shungu, D. C., Anjilvel, S., Chan, S. L., Ellis, S. P., Xanthopoulos, E. P., Malaspina, D., Gorman, J. M., Mann, J. J., Laruelle, M., et al. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00044-5 · Cited by 87
Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy
Deicken, R. F., Zhou, L., Schuff, N. W., Fein, G., & Weiner, M. W. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00490-3 · Cited by 86
Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report
Fukuzako, H., Takeuchia, K., Hokazono, Y., Fukuzako, T., Yamada, K., Hashiguchi, T., Obo, Y., Ueyama, K., Takigawa, M., & Fujimoto, T. (1995) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(95)02622-5 · Cited by 85
Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopy.
Choe, B., Suh, T., Shinn, K., Lee, C.-W., Lee, C., & Paik, I. (1996) · Investigative Radiology · doi:10.1097/00004424-199606000-00006 · Cited by 83
Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls
Yurgelun-Todd, D. A., Renshaw, P. F., Gruber, S. A., WATERNAUX, C. M., & Cohen, B. M. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(95)00071-2 · Cited by 82
Decreased left frontal lobe N-acetylaspartate in schizophrenia
Deicken, R. F., Zhou, L., Corwin, F. D., Vinogradov, S., & Weiner, M. W. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.688 · Cited by 82
Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study
Sigmundsson, T., Maier, M., Toone, B., Williams, S., Simmons, A., Greenwood, K., & Ron, M. A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00533-9 · Cited by 78
A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients
Bartha, R., Al-Semaan, Y. M., Williamson, P., Drost, D. J., MALLA, A. K., Carr, T. J., Densmore, M., Canaran, G., & Neufeld, R. W. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00007-4 · Cited by 77
Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia
Braus, D. F. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00003-2 · Cited by 77
Reproducibility of Proton Magnetic Resonance Spectroscopic Imaging in Patients with Schizophrenia
Bertolino, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00090-0 · Cited by 76
Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of drug effect
Heimberg, C., Komoroski, R. A., Lawson, W. B., Cardwell, D. A., & Karson, C. N. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00034-1 · Cited by 75
In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy
Kegeles, L. S., Humaran, T. J., & Mann, J. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00425-3 · Cited by 72
Working Memory Deficits and Levels of N-Acetylaspartate in Patients With Schizophreniform Disorder
Bertolino, A., Sciota, D., Brudaglio, F., Altamura, M., Blasi, G., Bellomo, A., Antonucci, N., Callicott, J. H., Goldberg, T. E., Scarabino, T., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.483 · Cited by 72
Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study
Block, W., Bayer, T. A., Tepest, R., Träber, F., Rietschel, M., Müller, D. J., Schulze, T. G., Honer, W. G., Maier, W., Schild, H. H., et al. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01264-7 · Cited by 71
1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia
Yamasue, H., Fukui, T., Fukuda, R., Yamada, H., Yamasaki, S., Kuroki, N., Abe, O., Kasai, K., Tsujii, K., Iwanami, A., et al. (2002) · Neuroreport · doi:10.1097/00001756-200211150-00029 · Cited by 71
Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia
Deicken, R. F., Zhou, L., Schuff, N. W., & Weiner, M. W. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00082-0 · Cited by 70
Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure
Bustillo, J., Lauriello, J., Rowland, L. M., Thomson, L., Petropoulos, H., Hammond, R., HART, B., & Brooks, W. M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00210-4 · Cited by 70
A Fully Automated Method for Tissue Segmentation and CSF-Correction of Proton MRSI Metabolites Corroborates Abnormal Hippocampal NAA in Schizophrenia
Weber‐Fahr, W., Ende, G., Braus, D. F., Bachert, P., Soher, B. J., Henn, F. A., & Büchel, C. (2002) · NeuroImage · doi:10.1006/nimg.2002.1057 · Cited by 69
Favorable Effect on Neuronal Viability in the Anterior Cingulate Gyrus due to Long-Term Treatment with Atypical Antipsychotics: [nl]An MRSI Study
Braus, D. F., Ende, G., Weber‐Fahr, W., Demirakça, T., & Henn, F. A. (2001) · Pharmacopsychiatry · doi:10.1055/s-2001-18037 · Cited by 69
1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia
Choe, B., Kim, K. T., Suh, T. S., Lee, C., Paik, I., Bahk, Y.-W., Shinn, K.-S., & Lenkinski, R. E. (1994) · Academic Radiology · doi:10.1016/s1076-6332(05)80716-0 · Cited by 64
Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia
Fannon, D. G., Simmons, A., Tennakoon, L., O’Ceallaigh, S., Sumich, A. L., Doku, V. C. K., Shew, C., & Sharma, T. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00185-9 · Cited by 64
High Choline Concentrations in the Caudate Nucleus in Antipsychotic-Naive Patients With Schizophrenia
Bustillo, J., Rowland, L. M., Lauriello, J., Petropoulos, H., Hammond, R., Hart, B. L., & Brooks, W. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.130 · Cited by 63
Brain N -acetylaspartate is elevated in Pelizaeus–Merzbacher disease with PLP1 duplication
Takanashi, J., Inoue, K., Tomita, M., Kurihara, A., Morita, F., Ikehira, H., Tanada, S., Yoshitome, E., & Kohno, Y. (2002) · Neurology · doi:10.1212/wnl.58.2.237 · Cited by 62
Preliminary study of frontal lobe 1H MR spectroscopy in childhood‐onset schizophrenia
Thomas, M. A., Ke, Y., Levitt, J. G., Caplan, R., Curran, J. G., Asarnow, R. F., & McCracken, J. T. (1998) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880080413 · Cited by 61
Reduced hippocampal N-acetylaspartate without volume loss in schizophrenia
Deicken, R. F., Pegues, M., & Amend, D. L. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00173-x · Cited by 61
Proton Magnetic Resonance Spectroscopy (1H MRS) in Schizophrenia: Investigation of the Right and Left Hippocampus, Thalamus, and Prefrontal Cortex
Delamillieure, P., Constans, J., Fernandez, J., Brazo, P., Benali, K., Courtheoux, P., Thibaut, F., Petit, M., & Dollfus, S. (2002) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006942 · Cited by 61
Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
Schuff, N. W., Capizzano, A. A., Du, A., Amend, D. L., O’Neill, J., Norman, D. M., Jagust, W. J., Chui, H. C., Kramer, J. H., Reed, B. R., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000078942.63360.22 · Cited by 60
Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia
Bustillo, J., Lauriello, J., Rowland, L. M., Jung, R. E., Petropoulos, H., Hart, B. L., Blanchard, J. J., Keith, S. J., & Brooks, W. M. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00102-0 · Cited by 59
Reduced Concentrations of Thalamic N-Acetylaspartate in Male Patients With Schizophrenia
Deicken, R. F., Johnson, C., Eliaz, Y., & Schuff, N. W. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.644 · Cited by 57
Lower Concentration of Thalamic N-Acetylaspartate in Patients With Schizophrenia: A Replication Study
Ende, G., Braus, D. F., Walter, S., & Henn, F. A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1314 · Cited by 57
Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia
Fujimoto, T., Nakano, T., Takano, T., Takeuchi, K., Yamada, K., Fukuzako, T., & Akimoto, H. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00316-9 · Cited by 56
Proton magnetic resonance spectroscopy in schizophrenia
Bertolino, A., & Weinberger, D. R. (1999) · European Journal of Radiology · doi:10.1016/s0720-048x(99)00052-2 · Cited by 54
Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy
Omori, M., Murata, T., Kimura, H., Koshimoto, Y., Kado, H., Ishimori, Y., Ito, H., & Wada, Y. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00049-4 · Cited by 53
Proton Magnetic Resonance Spectroscopy of the Medial Prefrontal Cortex in Patients With Deficit Schizophrenia: Preliminary Report
Delamillieure, P., Fernandez, J. Μ., Constans, J., Brazo, P., Benali, K., Abadie, P., Vasse, T., Thibaut, F., Courthè®μx, P., Petit, M., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.641 · Cited by 52
Neuropsychological Correlates of Basal Ganglia and Medial Temporal Lobe NAA/Cho Reductions in Traumatic Brain Injury
Ariza, M., Junqué, C., Mataró, M., Poca, M. A., Bargalló, N., Olondo, M., & Sahuquillo, J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.4.541 · Cited by 51
Frontal lobe of children with schizophrenia spectrum disorders: A proton magnetic resonance spectroscopic study
Brooks, W. M., Hodde-Vargas, J., Vargas, A., Yeo, R. A., Ford, C. C., & Hendren, R. L. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00462-9 · Cited by 49
Reproducibility of 1H‐MRS measurements in schizophrenic patients
Mullins, P. G., Rowland, L. M., Bustillo, J., Bedrick, E. J., Lauriello, J., & Brooks, W. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10598 · Cited by 47
In vitro 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia
Omori, M., Pearce, J., Komoroski, R. A., Griffin, W. S. T., Mrak, R. E., Husain, M. M., & Karson, C. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00409-x · Cited by 46
Evidence of Neuronal Injury Outside the Medial Temporal Lobe in Temporal Lobe Epilepsy:N-Acetylaspartate Concentration Reductions Detected with Multisection Proton MR Spectroscopic Imaging—Initial Experience
Vermathen, P., Laxer, K. D., Schuff, N. W., Matson, G. B., & Weiner, M. W. (2003) · Radiology · doi:10.1148/radiol.2261011668 · Cited by 46
The value of proton MR spectroscopy in pediatric metabolic brain disease.
Zimmerman, R. A., & Wang, Z. (1998) · PubMed · Cited by 46
1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
O’Neill, J., Levitt, J. G., Caplan, R., Asarnow, R., McCracken, J. T., Toga, A. W., & Alger, J. R. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.005 · Cited by 45
Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary report
Shioiri, T., Hamakaw, H., Kato, T., Murashita, J., Fujii, K., Inubushi, T., & Takahashi, S. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(96)00017-5 · Cited by 44
Evidence for altered cerebellar vermis neuronal integrity in schizophrenia
Deicken, R. F., Feiwell, R., Schuff, N. W., & Soher, B. J. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00103-2 · Cited by 43
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study
Maier, M., & Ron, M. A. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(96)00044-8 · Cited by 43
Multiregional 1 H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia
Ende, G., Braus, D. F., Walter, S., Weber‐Fahr, W., & Henn, F. A. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0398-5 · Cited by 34
Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: A preliminary report
Hagino, H., Suzuki, M., Mori, K., Nohara, S., Yamashita, I., Takahashi, T., Kurokawa, K., Matsui, M., Watanabe, N., Seto, H., et al. (2002) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2002.01045.x · Cited by 34
PROTON MR SPECTROSCOPY OF PEDIATRIC BRAIN TUMORS
Taylor, J. S., Ogg, R. J., & Langston, J. W. (1998) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00539-8 · Cited by 32
Basal ganglia N-acetylaspartate correlates with the performance in the procedural task ‘Tower of Hanoi’ of neuroleptic-naive schizophrenic patients
Giménez, M., Junqué, C., Pérez, M., Vendrell, P., Baeza, I., Salamero, M., Mercader, J. M., & Bernardo, M. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00698-0 · Cited by 32
Single-voxel proton magnetic resonance spectroscopy of the pons and cerebellum in patients with schizophrenia: a preliminary study1A portion of this investigation was presented at the Biennial Meeting of International Congress on Schizophrenia Research, Colorado Springs, CO, April 13, 1997.1
Eluri, R., Paul, C. R., Roemer, R., & Boyko, O. B. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00043-2 · Cited by 30
Subtype-associated metabolite differences in the temporal lobe in schizophrenia detected by proton magnetic resonance spectroscopy
Fukuzako, H., Kodama, S., Fukuzako, T., Yamada, K., Doi, W., Sato, D., & Takigawa, M. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00035-9 · Cited by 30
Correlation of Basal Ganglia Magnetic Resonance Spectroscopy With Apgar Score in Perinatal Asphyxia
Pavlakis, S. G., Kingsley, P. B., Harper, R., Buckwald, S., Spinazzola, R., Frank, Y., & Prohovnik, I. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1476 · Cited by 25
Abnormally high levels of brain N-acetylaspartate in children with sickle cell disease.
Steen, R. G., & Ogg, R. J. (2005) · PubMed · Cited by 24
Neural damage in the lenticular nucleus linked with tardive dyskinesia in schizophrenia: a preliminary study using proton magnetic resonance spectroscopy
Ando, K., Takei, N., Matsumoto, H., Iyo, M., Isoda, H., & Mori, N. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00290-0 · Cited by 21
Proton magnetic resonance spectroscopy of lenticular nuclei in simple schizophrenia
Ohara, K., Isoda, H., Suzuki, Y., Takehara, Y., Ochiai, M., Takeda, H., Hattori, K., Igarashi, Y., & Ohara, K. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00089-0 · Cited by 20
Proton MR spectroscopy of Wernicke encephalopathy.
Mascalchi, M., Belli, G., Guerrini, L., Nistri, M., Seppia, I. D., & Villari, N. (2002) · PubMed Central · Cited by 20
Heritability Heightens Brain Metabolite Differences in Schizophrenia
Fukuzako, H. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.1.95 · Cited by 18
Proton magnetic resonance spectroscopy (1H-MRS) of the cerebellum in men with schizophrenia.
Tibbo, P. G., Hanstock, C. C., Asghar, S., Silverstone, P. H., & Allen, P. S. (2000) · PubMed Central · Cited by 17
Proton magnetic resonance spectroscopy in children with Moyamoya disease
Shimizu, H., Shirane, R., Fujiwara, S., Takahashi, A., & Yoshimoto, T. (1997) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(97)00059-0 · Cited by 15
Differences in fMRI and MRS in a monozygotic twin pair discordant for schizophrenia (case report)
Španiel, F., Hájek, T., Tintěra, J., Harantová, P., Dezortová, M., & Hájek, M. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.02430.x · Cited by 13
Brain metabolite concentration ratios in vivo: multisite reproducibility by single-voxel 1H MR spectroscopy
Komoroski, R. A., Kotrla, K. J., Lemen, L. C., Lindquist, D. M., Diaz, P., & Foundas, A. L. (2004) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.12.001 · Cited by 12
Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics
Moore, C. M., Bonello, C. M., Sherwood, A. R., Cohen, B. M., Renshaw, P. F., & Yurgelun-Todd, D. A. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00302-4 · Cited by 10

Flagged first, then by citations

Sorted by citations

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,443
Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
Lesh, T. A., Niendam, T. A., Minzenberg, M., & Carter, C. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.156 · Cited by 522
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2487 · Cited by 399
Schizophrenia, “Just the Facts”: What we know in 2008
Tandon, R., Keshavan, M. S., & Nasrallah, H. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.022 · Cited by 430

See all 254

Authors: Steen, R. G., Hamer, R. M., & Lieberman, J. A.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Steen, R Grant
ORCID: Steen, R Grant
Lieberman, Jeffrey A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-08-10
Volume: 30
Issue: 11
Pages: 1949-1962
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300850
OpenAlex: W1965782412
Cited by: 254
References: 107
Citations by year: 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 16 · 2013: 27 · 2012: 14
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Foundation of Hope for Research and Treatment of Mental Illness
University of North Carolina at Chapel Hill
National Institute of Mental Health (MH-64065, R01MH061603, P50MH064065, MH 61603)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, N-acetylaspartate, brain metabolites, 1H NMR, hippocampus, frontal lobe, cortical gray matter, white matter, chronic schizophrenia, first-episode schizophrenia
MeSH terms: Aspartic Acid, Brain Chemistry, Humans, Magnetic Resonance Spectroscopy, Schizophrenia, Tritium

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks