Cited by 254Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsMental Health and Psychiatry

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Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

Steen, R Grant, Hamer, Robert M, Lieberman, Jeffrey A·2005·Neuropsychopharmacology

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Abstract

A systematic review of the literature identified 64 published English-language papers that used proton (1H) magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) concurrently in healthy controls and in patients with a diagnosis of schizophrenia (SZ). A total of 1209 controls and 1256 patients have been evaluated, with 88% of studies carried out at 1.5 T field strength, and 77% of studies focused on patients with chronic SZ. There is consistent evidence that NAA is reduced in a broad range of tissues in the SZ brain. Broad consensus (> or =10 studies) is emerging that NAA levels are reduced > or =5% in hippocampus and in both cortical gray matter (GM) and white matter (WM) of the frontal lobe. There is no evidence to support a hypothesis that relative NAA levels are reduced to a different degree in frontal lobe GM and WM, nor is there robust evidence of a difference in NAA levels between patients with first-episode and chronic SZ. Study reliability may be a problem, as most studies appear to be underpowered. With simple assumptions about the inherent difference in NAA levels between patients and controls, it can be calculated that a minimum sample size of approximately 39 patients and 39 controls is required for acceptable statistical power. Only three of 64 studies included enough subjects to have 80% power to detect a 10% NAA reduction in patients, and no studies were adequately powered to detect a 5% NAA reduction with 80% power.

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Authors: Steen, R. G., Hamer, R. M., & Lieberman, J. A.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Steen, R Grant
ORCID: Steen, R Grant
Lieberman, Jeffrey A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-08-10
Volume: 30
Issue: 11
Pages: 1949-1962
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300850
OpenAlex: W1965782412
Cited by: 254
References: 107
Citations by year: 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 16 · 2013: 27 · 2012: 14
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Foundation of Hope for Research and Treatment of Mental Illness
University of North Carolina at Chapel Hill
National Institute of Mental Health (MH-64065, R01MH061603, P50MH064065, MH 61603)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, N-acetylaspartate, brain metabolites, 1H NMR, hippocampus, frontal lobe, cortical gray matter, white matter, chronic schizophrenia, first-episode schizophrenia
MeSH terms: Aspartic Acid, Brain Chemistry, Humans, Magnetic Resonance Spectroscopy, Schizophrenia, Tritium

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Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis

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