The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis
Abstract
A systematic review of the literature identified 64 published English-language papers that used proton (1H) magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) concurrently in healthy controls and in patients with a diagnosis of schizophrenia (SZ). A total of 1209 controls and 1256 patients have been evaluated, with 88% of studies carried out at 1.5 T field strength, and 77% of studies focused on patients with chronic SZ. There is consistent evidence that NAA is reduced in a broad range of tissues in the SZ brain. Broad consensus (> or =10 studies) is emerging that NAA levels are reduced > or =5% in hippocampus and in both cortical gray matter (GM) and white matter (WM) of the frontal lobe. There is no evidence to support a hypothesis that relative NAA levels are reduced to a different degree in frontal lobe GM and WM, nor is there robust evidence of a difference in NAA levels between patients with first-episode and chronic SZ. Study reliability may be a problem, as most studies appear to be underpowered. With simple assumptions about the inherent difference in NAA levels between patients and controls, it can be calculated that a minimum sample size of approximately 39 patients and 39 controls is required for acceptable statistical power. Only three of 64 studies included enough subjects to have 80% power to detect a 10% NAA reduction in patients, and no studies were adequately powered to detect a 5% NAA reduction with 80% power.
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“An earlier meta-analysis made clear that N-acetyl aspartate levels are reduced in patients with schizophrenia in frontal lobe gray and white matter.60”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [60]
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Cites
A review of MRI findings in schizophrenia
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Reversible decreases in N‐acetylaspartate after acute brain injury
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Magnetic resonance spectroscopy in AD
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The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis
Tartaglia, M. C., Narayanan, S., Francis, S. J., dos Santos, A. C., Stefano, N. D., Lapierre, Y., & Arnold, D. L. (2004) · Archives of Neurology · doi:10.1001/archneur.61.2.201 · Cited by 207
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N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,443
Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
Lesh, T. A., Niendam, T. A., Minzenberg, M., & Carter, C. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.156 · Cited by 522
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2487 · Cited by 399
Schizophrenia, “Just the Facts”: What we know in 2008
Tandon, R., Keshavan, M. S., & Nasrallah, H. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.022 · Cited by 430
Metadata
- Authors
- Steen, R. G., Hamer, R. M., & Lieberman, J. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Steen, R Grant
- Venue
- Neuropsychopharmacology
- Published
- 2005-08-10
- Volume
- 30
- Issue
- 11
- Pages
- 1949-1962
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W1965782412
- Cited by
- 254
- References
- 107
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 21 · 2014: 16 · 2013: 27 · 2012: 14
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Foundation of Hope for Research and Treatment of Mental Illness
- University of North Carolina at Chapel Hill
- National Institute of Mental Health (MH-64065, R01MH061603, P50MH064065, MH 61603)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, N-acetylaspartate, brain metabolites, 1H NMR, hippocampus, frontal lobe, cortical gray matter, white matter, chronic schizophrenia, first-episode schizophrenia
- MeSH terms
- Aspartic Acid, Brain Chemistry, Humans, Magnetic Resonance Spectroscopy, Schizophrenia, Tritium
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