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Cited by 311Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 85 of the 88 references it cites were found in a registry or an index.

Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving

Wong, Dean F, Kuwabara, Hiroto, Schretlen, David J, Bonson, Katherine R, Zhou, Yun, Nandi, Ayon, Brašić, James R, Kimes, Alane S, Maris, Marika A, Kumar, Anil, Contoreggi, Carlo, Links, Jonathan, Ernst, Monique, Rousset, Olivier, Zukin, Stephen, Grace, Anthony A, Rohde, Charles, Jasinski, Donald R, Gjedde, Albert, London, Edythe D·2006·Neuropsychopharmacology
DOI 10.1038/sj.npp.1301194
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Abstract

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

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Crossref · 10.1038/sj.npp.1301194

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  1. Gerfen CR, Wilson CJ (1996). The basal ganglia. In: Swanson LW, Björklund A, Hökfelt T (eds). Integrated Systems of the CNS, Part III. Elsevier: New York. pp 371–468.

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Metadata

Authors
Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., Contoreggi, C., Links, J., Ernst, M., Rousset, O., Zukin, S., Grace, A. A., Rohde, C., Jasinski, D. R., Gjedde, A., & London, E. D.
Affiliations
  • Johns Hopkins University (US)
  • National Institutes of Health (US)
  • University of Pittsburgh (US)
  • Aarhus University (DK)
  • University of California, Los Angeles (US)
Corresponding author
Wong, Dean F
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2006-09-13
Volume
31
Issue
12
Pages
2716-2727
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1301194
OpenAlex
W2130978769
Cited by
311
References
88
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 17 · 2016: 19 · 2015: 14 · 2014: 25 · 2013: 34 · 2012: 28
FWCI
7.09
Type
journal article
Language
en
Update notices
erratum (2006-12-14)
Open access
closed
Licence
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Statens Naturvidenskabelige Forskningsrad
  • National Institutes of Health (5r01da011080-05)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA012839, AA12839)
  • National Institute on Drug Abuse (K24 DA00412, DA 11080, K24DA000412)
  • National Institute of Neurological Disorders and Stroke (NS-38927, R01NS038927)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cocaine craving, D2-like receptors, receptor occupancy, putamen, dorsal striatum, endogenous dopamine, cue reactivity, relapse
MeSH terms
Adult, Binding, Competitive, Brain Mapping, Carbon Radioisotopes, Cocaine, Corpus Striatum, Cues, Dopamine, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Synaptic Transmission, Neurons, Predictive Value of Tests, Receptors, Dopamine, Up-Regulation, Presynaptic Terminals, Dopamine Antagonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Raclopride, Positron-Emission Tomography

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