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Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving

Wong, Dean F, Kuwabara, Hiroto, Schretlen, David J, Bonson, Katherine R, Zhou, Yun, Nandi, Ayon, Brašić, James R, Kimes, Alane S, Maris, Marika A, Kumar, Anil, Contoreggi, Carlo, Links, Jonathan, Ernst, Monique, Rousset, Olivier, Zukin, Stephen, Grace, Anthony A, Rohde, Charles, Jasinski, Donald R, Gjedde, Albert, London, Edythe D·2006·Neuropsychopharmacology

DOI 10.1038/sj.npp.1301194

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Abstract

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

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Authors: Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., Contoreggi, C., Links, J., Ernst, M., Rousset, O., Zukin, S., Grace, A. A., Rohde, C., Jasinski, D. R., Gjedde, A., & London, E. D.
Affiliations: Johns Hopkins University (US)
National Institutes of Health (US)
University of Pittsburgh (US)
Aarhus University (DK)
University of California, Los Angeles (US)
Corresponding author: Wong, Dean F
ORCID: Wong, Dean F
Kuwabara, Hiroto
Schretlen, David J
Bonson, Katherine R
Zhou, Yun
Nandi, Ayon
Brašić, James R
Kimes, Alane S
Kumar, Anil
Links, Jonathan
Zukin, Stephen
Grace, Anthony A
Rohde, Charles
Gjedde, Albert
London, Edythe D
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-09-13
Volume: 31
Issue: 12
Pages: 2716-2727
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1301194
OpenAlex: W2130978769
Cited by: 311
References: 88
Citations by year: 2026: 2 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 17 · 2016: 19 · 2015: 14 · 2014: 25 · 2013: 34 · 2012: 28
FWCI: 7.09
Type: journal article
Language: en
Update notices: erratum (2006-12-14)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Statens Naturvidenskabelige Forskningsrad
National Institutes of Health (5r01da011080-05)
National Institute on Alcohol Abuse and Alcoholism (R01AA012839, AA12839)
National Institute on Drug Abuse (K24 DA00412, DA 11080, K24DA000412)
National Institute of Neurological Disorders and Stroke (NS-38927, R01NS038927)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: cocaine craving, D2-like receptors, receptor occupancy, putamen, dorsal striatum, endogenous dopamine, cue reactivity, relapse
MeSH terms: Adult, Binding, Competitive, Brain Mapping, Carbon Radioisotopes, Cocaine, Corpus Striatum, Cues, Dopamine, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Synaptic Transmission, Neurons, Predictive Value of Tests, Receptors, Dopamine, Up-Regulation, Presynaptic Terminals, Dopamine Antagonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Raclopride, Positron-Emission Tomography

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Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving

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