Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine

Variance stabilization applied to microarray data calibration and to the quantification of differential expression

Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440 · see citing works

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494 · see citing works

Pathways to neuronal injury and apoptosis in HIV-associated dementia

Kaul, M., Garden, G. A., & Lipton, S. A. (2001) · Nature · doi:10.1038/35073667 · Cited by 1,211 · see citing works

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works

HIV dementia: an evolving disease

McArthur, J. C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.042 · Cited by 469 · see citing works

Statistical Issues in cDNA Microarray Data Analysis

Smyth, G. K., Yang, J. Y. H., & Speed, T. P. (2003) · Humana Press eBooks · doi:10.1385/1-59259-364-x:111 · Cited by 463 · see citing works

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

Danysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404 · see citing works

Dopamine is a monoamine oxidase B substrate in man

Glover, V. A. S., Sandler, M. B., Owen, F., et al. (1977) · Nature · doi:10.1038/265080a0 · Cited by 333 · see citing works

Role of cytokines in inflammatory process in Parkinson’s disease

Sawada, M., Imamura, K., & Nagatsu, T. (2006) · Parkinson’s Disease and Related Disorders · doi:10.1007/978-3-211-45295-0_57 · Cited by 331 · see citing works

Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease

Jacob, C. P., Koutsilieri, E., Bartl, J., Neuen-Jacob, E., Arzberger, T., Zander, N., Ravid, R., Roggendorf, W., Riederer, P., & Grünblatt, E. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-11113 · Cited by 317 · see citing works

Neurotrophins: a family of proteins supporting the survival of neurons.

Barde, Y. (1994) · PubMed · Cited by 296 · see citing works

Cell death in HIV dementia

Mattson, M. P., Haughey, N. J., & Nath, A. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401577 · Cited by 285 · see citing works

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

Kornhuber, J., Mack-Burkhardt, F., Riederer, P. F., Hebenstreit, G. F., Reynolds, G. P., Andrews, H., & Beckmann, H. (1989) · Journal of Neural Transmission · doi:10.1007/bf01248936 · Cited by 250 · see citing works

HIV dementia: the role of the basal ganglia and dopaminergic systems

Berger, J. R., & Arendt, G. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400304 · Cited by 195 · see citing works

Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study

Schifitto, G., NAVIA, B. A., Yiannoutsos, C. T., Marra, C. M., Chang, L., Ernst, T. M., Jarvik, J. G., Miller, E. N., Singer, E. J., Ellis, R. J., et al. (2007) · AIDS · doi:10.1097/qad.0b013e32813384e8 · Cited by 166 · see citing works

A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques

ten Haaft, P., Verstrepen, B. E., Überla, K., Rosenwirth, B., & Heeney, J. L. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.10281-10285.1998 · Cited by 162 · see citing works

Memantine prevents HIV coat protein‐induced neuronal injury in vitro

Lipton, S. A. (1992) · Neurology · doi:10.1212/wnl.42.7.1403 · Cited by 157 · see citing works

The Neuroprotective Agent Memantine Induces Brain-Derived Neurotrophic Factor and trkB Receptor Expression in Rat Brain

Marvanová, M., Lakso, M., Pirhonen, J., Nawa, H., Wong, G., & Ċastrén, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1027 · Cited by 150 · see citing works

Variable benefit in neuropsychological function in HIV-infected HAART-treated patients

Cysique, L. A., Maruff, P. T., & Brew, B. J. (2006) · Neurology · doi:10.1212/01.wnl.0000210477.63851.d3 · Cited by 149 · see citing works

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine

Toggas, S. M., Masliah, E., & Mucke, L. (1996) · Brain Research · doi:10.1016/0006-8993(95)01197-8 · Cited by 140 · see citing works

Parkinsonism in HIV dementia

Koutsilieri, E., Sopper, S., Scheller, C., et al. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200063 · Cited by 128 · see citing works

Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection

Heyes, M. P. (2001) · Brain · doi:10.1093/brain/124.5.1033 · Cited by 124 · see citing works

Neuronal damage of the substantia nigra in HIV-1 infected brains

Itoh, K., Mehraein, P., & Weis, S. (2000) · Acta Neuropathologica · doi:10.1007/s004010051139 · Cited by 105 · see citing works

Brain‐derived neurotrophic factor regulates the expression of D1 dopamine receptors

Do, T., Kerr, B., & Kuzhikandathil, E. V. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04249.x · Cited by 100 · see citing works

Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter function

Wallace, D. R., Dodson, S., Nath, A., & Booze, R. M. (2005) · Synapse · doi:10.1002/syn.20214 · Cited by 98 · see citing works

The Metabolism of Dopamine by Both Forms of Monoamine Oxidase in the Rat Brain and Its Inhibition by Cimoxatone

Fowler, C. J., & Benedetti, M. S. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb08123.x · Cited by 94 · see citing works

Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat — a pharmacokinetic microdialysis study

Spanagel, R., Eilbacher, B., & Wilke, R. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90023-x · Cited by 92 · see citing works

Neurotrophins prevent HIV Tat‐induced neuronal apoptosis via a nuclear factor‐κB (NF‐κB)‐dependent mechanism

Ramirez, S. H., Sanchez, J. F., Dimitri, C. A., Gelbard, H. A., Dewhurst, S., & Maggirwar, S. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00467.x · Cited by 82 · see citing works

Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS

Roberts, E., Burudi, E. M. E., Flynn, C. T., Madden, L. J., Roinick, K. L., Watry, D. D., Zandonatti, M. A., Taffe, M. A., & Fox, H. S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.030 · Cited by 75 · see citing works

Memantine Protects Hippocampal Neuronal Function in Murine Human Immunodeficiency Virus Type 1 Encephalitis

Anderson, E., Gendelman, H. E., & Xiong, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1933-04.2004 · Cited by 70 · see citing works

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease

Guillin, O., Griffon, N., Bézard, E., Leriche, L., Díaz, J., Gross, C. E., & Sokoloff, P. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.096 · Cited by 64 · see citing works

Dopamine and Glutamate in Psychiatric Disorders

Schmidt, W., & Reith, M. E. A. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6 · Cited by 59 · see citing works

Involvement of dopamine in the progression of AIDS Dementia Complex

Koutsilieri, E., Sopper, S., Scheller, C., et al. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200032 · Cited by 59 · see citing works

A placebo-controlled study of memantine for the treatment of human immunodeficiency virus–associated sensory neuropathy

Schifitto, G., Yiannoutsos, C. T., Simpson, D. M., Marra, C. M., Singer, E. J., Kolson, D. L., Nath, A., Berger, J. R., & NAVIA, B. A. (2006) · Journal of NeuroVirology · doi:10.1080/13550280600873835 · Cited by 56 · see citing works

Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs

Czub, S., Czub, M., Koutsilieri, E., Sopper, S., Villinger, F. J., Müller, J. G., Stahl‐Hennig, C., Riederer, P. F., ter Meulen, V., & Gosztonyi, G. (2004) · Acta Neuropathologica · doi:10.1007/s00401-003-0801-3 · Cited by 52 · see citing works

Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum

Theodore, S., Cass, W. A., & Maragos, W. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.056 · Cited by 49 · see citing works

Early impairment in dopaminergic neurotransmission in brains of SIV‐infected rhesus monkeys due to microglia activation

Scheller, C., Sopper, S., Jenuwein, M., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03373.x · Cited by 48 · see citing works

Identification of Genes Regulated by Memantine and MK-801 in Adult Rat Brain by cDNA Microarray Analysis

Marvanová, M., Lakso, M., & Wong, G. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300398 · Cited by 42 · see citing works

Microdialysis studies with amantadine and memantine on pharmacokinetics and effects on dopamine turnover.

Quack, G., Hesselink, M. B., Danysz, W., et al. (1995) · PubMed · Cited by 41 · see citing works

Trophic Factors in Cerebrospinal Fluid and Spinal Cord of Patients with Tropical Spastic Paraparesis, HIV, and Creutzfeldt-Jakob Disease

Albrecht, D. E., Garcı́a, L., Cartier, L., Kettlun, A. M., Vergara, C. G., Collados, L., & Valenzuela, M. A. (2006) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.22.248 · Cited by 36 · see citing works

Dopamine deficits and regulation of the cAMP second messenger system in brains of simian immunodeficiency virus–infected rhesus monkeys

Jenuwein, M., Scheller, C., Neuen-Jacob, E., et al. (2004) · Journal of NeuroVirology · doi:10.1080/13550280490448016 · Cited by 32 · see citing works

Catecholamine research : from molecular insights to clinical medicine

Nagatsu, T., Nagashima, T., McCarty, R. C., et al. (2002) · Medical Entomology and Zoology · Cited by 30 · see citing works

Involvement of Microglia in Cerebrospinal Fluid Glutamate Increase in SIV-Infected Rhesus Monkeys (Macaca mulatta)

Koutsilieri, E., Sopper, S., Heinemann, T., et al. (1999) · AIDS Research and Human Retroviruses · doi:10.1089/088922299311222 · Cited by 29 · see citing works

Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats

Hesselink, M. B., de Boer, A. G., Breimer, D. D., & Danysz, W. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050201 · Cited by 29 · see citing works

Up‐regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251‐infected macaques without major brain involvement

Bossuet, C., Vaufrey, F., Condé, F., et al. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02237.x · Cited by 17 · see citing works

In vivo studies on the effects of memantine on dopamine metabolism in the striatum and n. accumbens of the rat.

Hw, C., Grote, C., Svensson, L., et al. (1995) · PubMed · Cited by 14 · see citing works

Glutamate and Neurodegeneration

Novelli, A., Pérez‐Basterrechea, M., & Fernández‐Sánchez, M. T. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_19 · Cited by 8 · see citing works

Dopamine Is a Pathogenetic Factor in HIV-Induced Neuro-AIDS

Koutsilieri, E., Scheller, C., Czub, S., et al. (2002) · Advances in behavioral biology · doi:10.1007/978-1-4757-3538-3_113 · Cited by 4 · see citing works

Untitled work

Solano (2000) · doi:10.1002/1531-8249(200002)47:2 · Cited by 3 · see citing works

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820 · see citing works

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications

Folch, J., Busquets, O., Ettcheto, M., Sánchez-López, E., Castro-Torres, R. D., Verdaguer, E., Garcia, M. L., Olloquequi, J., Casadesús, G., Beas-Zarate, C., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170672 · Cited by 245 · see citing works

The role of dopamine in inflammation-associated depression: mechanisms and therapeutic implications

Felger, J. C. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_13 · Cited by 115 · see citing works

Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers

Kumamoto, T., Nakajima, M., Uga, R., Ihayazaka, N., Kashihara, H., Katakawa, K., Ishikawa, T., Saiki, R., Nishimura, K., & Igarashi, K. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.12.021 · Cited by 16 · see citing works

Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons

Maler, J. M., Esselmann, H., Wiltfang, J., Kunz, N., Lewczuk, P., Reulbach, U., Bleich, S., Rüther, E., & Kornhuber, J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.017 · Cited by 44 · see citing works

Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization

Glasgow, N. G., Povysheva, N. V., Azofeifa, A. M., & Johnson, J. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1173-17.2017 · Cited by 100 · see citing works

In vivo evidence for functional NMDA receptor blockade by memantine in rat hippocampal neurons

Szegedi, V., Juhász, G., Parsons, C. G., & Budai, D. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0471-y · Cited by 15 · see citing works

Effects of Mg2+ on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site

Glasgow, N. G., Wilcox, M. R., & Johnson, J. W. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.017 · Cited by 30 · see citing works