Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works

High density synthetic oligonucleotide arrays

Lipshutz, R. J., Fodor, S. P. A., Gingeras, T., & Lockhart, D. J. (1999) · Nature Genetics · doi:10.1038/4447 · Cited by 2,204 · see citing works

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works

Gene-expression profile of the ageing brain in mice

Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909 · see citing works

Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations

Lee, M. T., Kuo, F. C., Whitmore, G. A., & Sklar, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.9834 · Cited by 861 · see citing works

Kainic Acid-Mediated Excitotoxicity as a Model for Neurodegeneration

Wang, Q., Yu, S. O., Simonyi, Á., Sun, G. Y., & Sun, A. Y. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:003 · Cited by 365 · see citing works

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

Grünblatt, E., Mandel, S. A., Jacob‐Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P. F., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0212-1 · Cited by 358 · see citing works

Pattern of brain destruction in Parkinson's and Alzheimer's diseases

Braak, H., Braak, E., Yilmazer‐Hanke, D., de Vos, R. A. I., Jansen, E. N. H., & Böhl, J. (1996) · Journal of Neural Transmission · doi:10.1007/bf01276421 · Cited by 326 · see citing works

Computational methods for theidentification of differential and coordinated gene expression

Claverie, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1821 · Cited by 287 · see citing works

Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

Scheff, S. W., & Price, D. A. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s312 · Cited by 284 · see citing works

β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors

Floden, A. M., Li, S., & Combs, C. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4998-04.2005 · Cited by 246 · see citing works

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation

Amadoro, G., Ciotti, M. T., Costanzi, M., Cestari, V., Calissano, P., & Canu, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511065103 · Cited by 243 · see citing works

Elimination of Primer–Dimer Artifacts and Genomic Coamplification Using a Two-Step SYBR Green I Real-Time RT-PCR

Vandesompele, J., Paepe, A. D., & Speleman, F. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5564 · Cited by 231 · see citing works

RNA Amplification Results in Reproducible Microarray Data with Slight Ratio Bias

Puskás, L. G., Zvara, Á., Hackler, L., & Hummelen, P. V. (2002) · BioTechniques · doi:10.2144/02326mt04 · Cited by 226 · see citing works

Expression in brain of amyloid precursor protein mutated in the alpha‐secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

Moechars, D., Lorent, K., De Strooper, B., Dewachter, I., & Van Leuven, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00468.x · Cited by 201 · see citing works

NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production

Lesné, S., Ali, C., Gabriel, C., Croci, N., MacKenzie, E. T., Glabe, C. G., Plotkine, M., Marchand‐Leroux, C., Vivien, D., & Buisson, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0849-05.2005 · Cited by 198 · see citing works

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

Lukiw, W. J., & Bazan, N. G. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980901)53:5 · Cited by 183 · see citing works

EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis

Svaren, J. P., Ehrig, T., Abdulkadir, S. A., Ehrengruber, M. U., Watson, M. A., & Milbrandt, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005220200 · Cited by 169 · see citing works

Alzheimer's disease: amyloid plaques in the cerebellum

Braak, H., Braak, E., Böhl, J., & Lang, W. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90197-4 · Cited by 157 · see citing works

Quantification of splice variants using real-time PCR

Vandenbroucke, I. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.e68 · Cited by 150 · see citing works

Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule

Blanchard, B. J., Chen, A., Rozeboom, L. M., Stafford, K. A., Weigele, P., & Ingram, V. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405941101 · Cited by 146 · see citing works

Abnormal Glutamate Transport Function in Mutant Amyloid Precursor Protein Transgenic Mice

Masliah, E., Alford, M. F., Mallory, M. E., Rockenstein, E. M., Moechars, D., & LEUVEN, F. V. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7386 · Cited by 145 · see citing works

Differential Gene Expression Patterns Revealed by Oligonucleotide Versus Long cDNA Arrays

Li, J. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.2.383 · Cited by 121 · see citing works

Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis

Benoît, M., Koulibaly, P. M., Migneco, O., Darcourt, J., Pringuey, D., & Robert, P. H. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00003-3 · Cited by 119 · see citing works

Differential expression of N‐methyl‐d‐aspartate receptor NR2 isoforms in Alzheimer's disease

Hynd, M., Scott, H., & Dodd, P. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02548.x · Cited by 118 · see citing works

Free radicals in Parkinson's disease

Koutsilieri, E., Scheller, C., Grünblatt, E., Keinosuke, N. A. R. A., Li, J., & Riederer, P. F. (2002) · Journal of Neurology · doi:10.1007/s00415-002-1201-7 · Cited by 117 · see citing works

A comparison of statistical methods for analysis of high density oligonucleotide array data

Rajagopalan, D. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg202 · Cited by 112 · see citing works

Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization

Groot, C. J. A. D., Langeveld, C. H., Jongenelen, C. A. M., Montagne, L., van der Valk, P., & Dijkstra, C. D. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970801)49:3 · Cited by 97 · see citing works

Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer’s disease

Zoia, C., Cogliati, T., Tagliabue, E., Cavaletti, G., Sala, G., Galimberti, G., Rivolta, I., Rossi, V., Frattola, L., & Ferrarese, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00085-x · Cited by 85 · see citing works

Alzheimer's disease: neuropathological correlates of cognitive and motor disorders

Mölsä, P. K., Säkö, E., Paljärvi, L., Rinne, J. O., & Rinne, U. K. (1987) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1987.tb05465.x · Cited by 68 · see citing works

Gene expression profile in streptozotocin rat model for sporadic Alzheimer?s disease

Grünblatt, E., Hoyer, S., & Riederer, P. F. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0030-x · Cited by 63 · see citing works

From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain

Riederer, P. F., & Hoyer, S. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0591-6 · Cited by 58 · see citing works

Hippocampal sclerosis in Alzheimer disease and other dementias

Attems, J., & Jellinger, K. A. (2006) · Neurology · doi:10.1212/01.wnl.0000200959.50898.26 · Cited by 54 · see citing works

Therapeutic Potential of Positive AMPA Receptor Modulators in the Treatment of Neuropsychiatric Disorders

Marenco, S., & Weinberger, D. R. (2006) · CNS Drugs · doi:10.2165/00023210-200620030-00001 · Cited by 45 · see citing works

Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous β‐amyloid and trimethyl‐tin

Liu, M., Sun, A., Shin, E., Liu, X., Kim, S. I., Runyons, C. R., Markesbery, W. R., Kim, H., & Bing, G. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04724.x · Cited by 45 · see citing works

Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review

Болдырев, А. А., Bulygina, E. R., & Makhro, A. (2004) · Neurotoxicity Research · doi:10.1007/bf03033454 · Cited by 44 · see citing works

Oxidative stress related markers in the “VITA” and the centenarian projects

Grünblatt, E., Schlosser, R. J., Fischer, P. A., Fischer, M. O., Li, J., Koutsilieri, E., Wichart, I., Sterba, N., Rujescu, D., Møller, H. J., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.001 · Cited by 32 · see citing works

Rapid impact of ?-amyloid on Paxillin in a neural cell line

Berg, M. M., Krafft, G. A., & Klein, W. L. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971215)50:6 · Cited by 26 · see citing works

Fluorescent multicolor multiplex homogeneous assay for the simultaneous analysis of the two most common hemochromatosis mutations

Ugozzoli, L. A., Chinn, D., & Hamby, K. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00016-7 · Cited by 21 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

Tu, S., Okamoto, S., Lipton, S. A., & Xu, H. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-48 · Cited by 582 · see citing works

The Role of NMDA Receptors in Alzheimer’s Disease

Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535 · see citing works

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500 · see citing works

Molecular and cellular mechanisms of excitotoxic neuronal death

Wang, Y., & Qin, Z. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0481-0 · Cited by 447 · see citing works

Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

Tam, K. Y., & Ju, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320970 · Cited by 416 · see citing works

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401 · see citing works

Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

Andersen, J. V., Markussen, K. H., Jakobsen, E., Schousboe, A., Waagepetersen, H. S., Rosenberg, P. A., & Aldana, B. I. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108719 · Cited by 375 · see citing works

Mechanisms of Glutamate Transport

Vandenberg, R. J., & Ryan, R. M. (2013) · Physiological Reviews · doi:10.1152/physrev.00007.2013 · Cited by 349 · see citing works

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

Pchitskaya, E. I., Александровна, П. Е., & Борисович, Б. И. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.06.008 · Cited by 346 · see citing works

The essential elements of Alzheimer’s disease

Lei, P., Ayton, S., & Bush, A. I. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.008207 · Cited by 336 · see citing works

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312 · see citing works

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer’s Disease and Amyloid Neuroprotection

Buckingham, S. D., Jones, A. K., Brown, L. A., & Sattelle, D. B. (2009) · Pharmacological Reviews · doi:10.1124/pr.108.000562 · Cited by 307 · see citing works

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

Revett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Li, S., & Selkoe, D. J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15007 · Cited by 264 · see citing works

Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle

Andersen, J. V., Schousboe, A., & Verkhratsky, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102331 · Cited by 259 · see citing works

Human astrocytes in the diseased brain

Dossi, E., Vasile, F., & Rouach, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.001 · Cited by 250 · see citing works

Astrocyte dysfunction in Alzheimer disease

Acosta, C., Anderson, H. D., & Anderson, C. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24075 · Cited by 248 · see citing works

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Silva, I., Silva, J., Ferreira, R., & Trigo, D. (2021) · Neurological Research and Practice · doi:10.1186/s42466-021-00102-7 · Cited by 234 · see citing works

Recent progress of drug nanoformulations targeting to brain

Khan, A. R., Yang, X., Fu, M., & Zhai, G. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.004 · Cited by 212 · see citing works

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211 · see citing works

Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

Takahashi, K., Foster, J. B., & Lin, C. G. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1937-8 · Cited by 213 · see citing works

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

Mota, S. I., Ferreira, I. L., & Rego, A. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.013 · Cited by 206 · see citing works

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

Scott, H. A., Gebhardt, F. M., Mitrovic, A. D., Vandenberg, R. J., & Dodd, P. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.008 · Cited by 202 · see citing works

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

Olabarria, M., Noristani, H. N., Verkhratsky, A., & Rodriguez, J. J. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-55 · Cited by 199 · see citing works

Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

Meftah, S., & Gan, J. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1129036 · Cited by 197 · see citing works

The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain

Gąsiorowska, A., Wydrych, M., Drapich, P., Zadrożny, M., Steczkowska, M., Niewiadomski, W., & Niewiadomska, G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654931 · Cited by 192 · see citing works

Amyloid-β _1–42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

Scimemi, A., Meabon, J. S., Woltjer, R. L., Sullivan, J. M., Diamond, J. S., & Cook, D. G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5274-12.2013 · Cited by 185 · see citing works

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders

O'Donovan, S. M., Sullivan, C. R., & McCullumsmith, R. E. (2017) · Schizophrenia · doi:10.1038/s41537-017-0037-1 · Cited by 184 · see citing works

Alzheimer’s disease: Targeting the glutamatergic system

Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180 · see citing works

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

Lewerenz, J., & Maher, P. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807325200 · Cited by 173 · see citing works

GluN2B subunit-containing NMDA receptor antagonists prevent Aβ-mediated synaptic plasticity disruption in vivo

Hu, N., Klyubin, I. V., Anwyl, R., & Rowan, M. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908083106 · Cited by 170 · see citing works

Decreased levels of PSD95 and two associated proteins and increased levels of BCl 2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

Rukhsana Sultana, A., Banks, W. A., & Butterfield, D. A. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22227 · Cited by 171 · see citing works

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

Paula‐Lima, A. C., Brito‐Moreira, J., & Ferreira, S. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12304 · Cited by 170 · see citing works

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System

Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225671 · Cited by 170 · see citing works

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases

Todd, A., & Hardingham, G. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249607 · Cited by 170 · see citing works

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

Bukke, V. N., Moola, A., Villani, R., Romano, A. D., Wawrzyniak, A., Balawender, K., Orkisz, S., Beggiato, S., Serviddio, G., & Cassano, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207452 · Cited by 160 · see citing works

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

Mookherjee, P., Green, P. S., Watson, G. S., Marques, M. A., Tanaka, K., Meeker, K. D., Meabon, J. S., Li, N., Zhu, P., Olson, V. G., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110503 · Cited by 164 · see citing works

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

Lei, M., Xu, H., Li, Z., Wang, Z., O’Malley, T. T., Zhang, D., Walsh, D. M., Xu, P., Selkoe, D. J., & Li, S. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.019 · Cited by 162 · see citing works

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

Takahashi, K., Kong, Q., Lin, Y., Stouffer, N., Schulte, D. A., Lai, L., Liu, Q., Chang, L., Dominguez, S., Xing, X., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20140413 · Cited by 157 · see citing works

The solute carrier transporters and the brain: Physiological and pharmacological implications

Hu, C., Tao, L., Cao, X., & Chen, L. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.09.002 · Cited by 157 · see citing works

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

Kong, Q., Chang, L.-C., Takahashi, K., Liu, Q., Schulte, D. A., Lai, L., Ibabao, B., Lin, Y., Stouffer, N., Mukhopadhyay, C. D., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66163 · Cited by 156 · see citing works

Biomarkers for Alzheimer’s disease and other forms of dementia: Clinical needs, limitations and future aspects

Cedazo-Mı́nguez, Á., & Winblad, B. G. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.09.008 · Cited by 156 · see citing works

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Shah, D., Gsell, W., Wahis, J., Luckett, E. S., Jamoulle, T., Vermaercke, B., Preman, P., Moechars, D., Hendrickx, V., Jaspers, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111280 · Cited by 153 · see citing works

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

Zumkehr, J., Rodríguez‐Ortiz, C. J., Cheng, D., Kieu, Z., Wai, T., Hawkins, C., Kilian, J., Lim, S., Medeiros, R., & Kitazawa, M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.005 · Cited by 152 · see citing works

The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances

Andersen, J. V. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70029 · Cited by 156 · see citing works

Glutamate Transporter EAAT2: A New Target For The Treatment Of Neurodegenerative Diseases

Lin, C. G., Kong, Q., Cuny, G. D., & Glicksman, M. A. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.122 · Cited by 147 · see citing works

Target Identification for CNS Diseases by Transcriptional Profiling

Altar, C. A., Vawter, M. P., & Ginsberg, S. D. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.172 · Cited by 139 · see citing works

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A.-L., & Kent, T. A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101716 · Cited by 142 · see citing works

Role of Aβ in Alzheimer’s-related synaptic dysfunction

Zhang, H., Jiang, X., Ma, L., Wei, W., Li, Z., Chang, S., Wen, J., Sun, J., & Li, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964075 · Cited by 144 · see citing works

Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

Magi, S., Castaldo, P., Macrì, M. L., Maiolino, M., Matteucci, A., Bastioli, G., Gratteri, S., Amoroso, S., & Lariccia, V. (2016) · BioMed Research International · doi:10.1155/2016/6701324 · Cited by 137 · see citing works

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

Sidoryk‐Wȩgrzynowicz, M., Gerber, Y. N., Ries, M., Sastre, M., Tolkovsky, A. M., & Spillantini, M. G. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0478-9 · Cited by 137 · see citing works

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics

Mallach, A., Zielonka, M., van Lieshout, V., An, Y., Khoo, J. H., Vanheusden, M., Chen, W.-T., Moechars, D., Arancibia-Carcamo, I. L., Fiers, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114216 · Cited by 135 · see citing works

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

Marttinen, M., Kurkinen, K. M. A., Soininen, H. S., Haapasalo, A., & Hiltunen, M. O. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0013-z · Cited by 129 · see citing works

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

Owen, J. B., Rukhsana Sultana, A., Aluise, C. D., Erickson, M. A., Price, T. O., Bu, G., Banks, W. A., & Butterfield, D. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.013 · Cited by 130 · see citing works

Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer’s Disease Progression

Findley, C. A., Bartke, A., Hascup, K. N., & Hascup, E. R. (2019) · ASN NEURO · doi:10.1177/1759091419855541 · Cited by 124 · see citing works

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

Xia, D., Lianoglou, S., Sandmann, T., Calvert, M., Suh, J. H., Thomsen, E., Dugas, J., Pizzo, M. E., DeVos, S. L., Earr, T. K., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00547-7 · Cited by 124 · see citing works

The Many Faces of Astrocytes in Alzheimer's Disease

Monterey, M. D., Wei, H., Wu, X., & Wu, J. Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.619626 · Cited by 117 · see citing works

Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

Pereira, A. C., Gray, J. D., Kogan, J. F., Davidson, R. L., Rubin, T. G., Okamoto, M., Morrison, J. H., & McEwen, B. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.33 · Cited by 116 · see citing works

Contribution of astrocytes to neuropathology of neurodegenerative diseases

Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 115 · see citing works

Susceptibility to calcium dysregulation during brain aging

Kumar, A. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.002.2009 · Cited by 115 · see citing works

Astrocytic Glutamatergic Transmission and Its Implications in Neurodegenerative Disorders

Satarker, S., Bojja, S. L., Gurram, P. C., Mudgal, J., Arora, D. S., & Nampoothiri, M. (2022) · Cells · doi:10.3390/cells11071139 · Cited by 112 · see citing works

Region- and Age-Specific Changes in Glutamate Transport in the AβPP23 Mouse Model for Alzheimer's Disease

Schallier, A., Smolders, I., Van Dam, D., Loyens, E., De Deyn, P. P., Michotte, A., Michotte, Y., & Massie, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101005 · Cited by 109 · see citing works

Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium

Betzen, C., White, R., Zehendner, C. M., Pietrowski, E., Bender, B., Luhmann, H. J., & Kuhlmann, C. R. W. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.034 · Cited by 109 · see citing works

Calcineurin and glial signaling: neuroinflammation and beyond

Furman, J. L., & Norris, C. M. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0158-7 · Cited by 111 · see citing works

Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 107 · see citing works

Molecular Profiles of Drinking Alcohol to Intoxication in C57BL/6J Mice

Mulligan, M. K., Rhodes, J. S., Crabbe, J. C., Mayfield, R. D., Harris, R. A., & Ponomarev, I. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01384.x · Cited by 104 · see citing works

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer’s Disease: What are the Roadblocks and How Can They Be Overcome?

Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150136 · Cited by 102 · see citing works

Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

Nanclares, C., Baraibar, A. M., Araque, A., & Kofuji, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157887 · Cited by 96 · see citing works

The Amyloid Cascade Hypothesis in Alzheimer’s Disease: Should We Change Our Thinking?

Kurkinen, M. T., Fułek, M., Fułek, K., Beszłej, J. A., Kurpas, D., & Leszek, J. (2023) · Biomolecules · doi:10.3390/biom13030453 · Cited by 102 · see citing works

Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder

Chandley, M., Szebeni, K., Szebeni, A., Crawford, J. D., Stockmeier, C. A., Turecki, G., Miguel-Hidalgo, J. J., & Ordway, G. A. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120110 · Cited by 100 · see citing works

Glial connexin expression and function in the context of Alzheimer's disease

Koulakoff, A., Mei, X., Orellana, J. A., Sáez, J. C., & Giaume, C. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.10.001 · Cited by 97 · see citing works

Tau-mediated synaptic damage in Alzheimer’s disease

Jadhav, S., Cubinkova, V., Zimova, I., Brezováková, V., Maďari, A., Cigánková, V., & Žilka, N. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0023 · Cited by 92 · see citing works

Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer’s Disease

Toniolo, S., Sen, A., & Husain, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239318 · Cited by 94 · see citing works

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer’s disease

Foster, T. C., Kyritsopoulos, C., & Kumar, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.012 · Cited by 92 · see citing works

Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

(2019) · doi:10.1073/pnas.1903566116 · Cited by 92 · see citing works

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease

Hector, A., & Brouillette, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.600084 · Cited by 90 · see citing works

Glial Glutamine Homeostasis in Health and Disease

Andersen, J. V., & Schousboe, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03771-1 · Cited by 88 · see citing works

Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy

Zheng, K., Dong, Y., Yang, R., Liang, Y., Wu, H., & He, Z. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105580 · Cited by 87 · see citing works

Increased expression of cholesterol 24S‐hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

Tian, G., Kong, Q., Lai, L., Ray‐Chaudhury, A., & Lin, C. G. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06661.x · Cited by 87 · see citing works

Glutamate transporters

Benarroch, E. E. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cc89e3 · Cited by 86 · see citing works

Excitotoxicity and new antiglutamatergic strategies in Parkinson's disease and Alzheimer's disease

Koutsilieri, E., & Riederer, P. F. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70025-7 · Cited by 84 · see citing works

Integrated multi-omics analysis of Alzheimer’s disease shows molecular signatures associated with disease progression and potential therapeutic targets

Kodam, P., Sai Swaroop, R., Pradhan, S. S., Sivaramakrishnan, V., & Vadrevu, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-30892-6 · Cited by 82 · see citing works

Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 82 · see citing works

The dual face of glutamate: from a neurotoxin to a potential survival factor—metabolic implications in health and disease

Magi, S., Piccirillo, S., & Amoroso, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-3002-x · Cited by 79 · see citing works

Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

Peterson, A. R., & Binder, D. K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00164 · Cited by 78 · see citing works

Epilepsy and Alzheimer’s Disease: Potential mechanisms for an association

Giorgi, F. S., Saccaro, L. F., Busceti, C. L., Biagioni, F., & Fornai, F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.009 · Cited by 76 · see citing works

A stocked toolbox for understanding the role of astrocytes in disease

Almad, A., & Maragakis, N. J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0010-2 · Cited by 76 · see citing works

Calcium signalling: A common target in neurological disorders and neurogenesis

Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.12.002 · Cited by 75 · see citing works

Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine

for the German Competence Network HIV/AIDS, Meisner, F., Scheller, C., Kneitz, S., Sopper, S., Neuen-Jacob, E., Riederer, P., Meulen, V. T., & Koutsilieri, E. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301615 · Cited by 73 · see citing works

Aberrant Detergent-Insoluble Excitatory Amino Acid Transporter 2 Accumulates in Alzheimer Disease

Woltjer, R. L., Duerson, K. C., Fullmer, J. M., Mookherjee, P., Ryan, A. M., Montine, T. J., Kaye, J. A., Quinn, J. F., Silbert, L. C., Erten‐Lyons, D., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181e24adb · Cited by 73 · see citing works

Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

Olajide, O. J., Suvanto, M. E., & Chapman, C. A. (2021) · Biology Open · doi:10.1242/bio.056796 · Cited by 71 · see citing works

A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73 · see citing works

Functional implications of the association of tau with the plasma membrane

Pooler, A. M., & Hanger, D. P. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381012 · Cited by 72 · see citing works

Altered expression of glutamate transporter‐1 and water channel protein aquaporin‐4 in human temporal cortex with Alzheimer's disease

Hoshi, A., Tsunoda, A., Yamamoto, T., Tada, M., Kakita, A., & Ugawa, Y. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12475 · Cited by 70 · see citing works

Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer’s Disease

Cox, M. F., Hascup, E. R., Bartke, A., & Hascup, K. N. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.929474 · Cited by 70 · see citing works

Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology

Gunes, Z. I., Kan, V. W. Y., Ye, X., & Liebscher, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00573 · Cited by 67 · see citing works

Fyn, a Potential Target for Alzheimer's Disease

Yang, K., Belrose, J. C., Trepanier, C. H., Lei, G., Jackson, M. F., & MacDonald, J. F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110353 · Cited by 66 · see citing works

Neuronal Expression of Splice Variants of “Glial” Glutamate Transporters in Brains Afflicted by Alzheimer’s Disease: Unmasking an Intrinsic Neuronal Property

Pow, D. V., & Cook, D. G. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9957-0 · Cited by 24 · see citing works

Amyloid‐beta1–42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus

Yeung, J. H. Y., Guzmán, B. C., Palpagama, T. H., Ethiraj, J., Zhai, Y., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15099 · Cited by 24 · see citing works

EAAT2 Expression in the Hippocampus, Subiculum, Entorhinal Cortex and Superior Temporal Gyrus in Alzheimer’s Disease

Yeung, J. H. Y., Palpagama, T. H., Wood, O. W. G., Turner, C. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702824 · Cited by 26 · see citing works

Issue Cover (October 2020)

(2020) · Journal of Neurochemistry · doi:10.1111/jnc.14763 · Cited by 1 · see citing works

P3–199: The glutamate transporter, EAAT3 (EAAC1), is aberrantly expressed in hippocampus of individuals with Alzheimer's disease

Cook, D. G., Deurson, K., Leverenz, J. B., Bird, T. D., Montine, T. J., & Pow, D. V. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1467