Promoter function and structure of the growth factorinducible immediate early gene cyr 61

Latinkic, Branko V.; Brien, Timothy P.O; Lau, Lester F.

doi:10.1093/nar/19.12.3261

Cited by 87Genomics and Chromatin DynamicsConnective Tissue Growth Factor ResearchSignaling Pathways in Disease

Promoter function and structure of the growth factorinducible immediate early gene cyr 61

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Latinkic, Branko V., Brien, Timothy P.O, Lau, Lester F.·1991·Nucleic Acids Research

DOI 10.1093/nar/19.12.3261PMC PMC328320

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Abstract

cyr61 is an immediate early gene that is transcriptionally activated in 3T3 fibroblasts by serum, platelet-derived growth factor, fibroblast growth factor, and the tumor promoter TPA with kinetics similar to the induction of c-fos. cyr61 encodes a secreted protein that is associated with the cell surface and the extracellular matrix, and may play a role in cell-cell communication. We report here the complete nucleotide sequence of the mouse cyr61 gene, which contains four short introns. The transcription start site was mapped by S1 nuclease and primer extension analyses. A 2 kb 5' flanking DNA fragment functions as a serum-inducible promoter. This DNA fragment contains a poly(CA) sequence that can adopt the Z DNA form. In addition, it contains a sequence that resembles the serum response element (SRE) originally identified in the c-fos promoter. We show that deletion of the cry61 SRE-like sequence abrogates serum inducibility. Furthermore, this SRE-like sequence is sufficient to confer serum and growth factor inducibility when linked to a basal promoter, and binds the 67 kD serum response factor in vitro. We conclude that the cyr61 SRE functions as a serum response element and may account for the coordinate activation of cyr61 and c-fos.

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Authors: Latinkic, B. V., Brien, T. P. O., & Lau, L. F.
Affiliations: University of Illinois Chicago (US)
ORCID: Latinkic, Branko V.
Lau, Lester F.
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 1991
Volume: 19
Issue: 12
Pages: 3261-3267
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/19.12.3261
PMC: PMC328320
OpenAlex: W1991095318
Cited by: 87
References: 53
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 1.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Nucleic Acids Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Cancer Society
National Cancer Institute (R01CA052220)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: CYR61, immediate early genes, serum response element, serum response factor, transcriptional regulation, 3T3 fibroblasts, platelet-derived growth factor, fibroblast growth factor, c-fos, extracellular matrix, intercellular communication, 5'-flanking region, Z-DNA
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cell Line, DNA, DNA-Binding Proteins, Fibroblast Growth Factors, Gene Expression Regulation, Growth Substances, Introns, Molecular Sequence Data, Nuclear Proteins, Platelet-Derived Growth Factor, Promoter Regions, Genetic, Proteins, Tetradecanoylphorbol Acetate, Transcription, Genetic, Restriction Mapping, Signal Transduction, Immediate-Early Proteins, Serum Response Factor, Intercellular Signaling Peptides and Proteins, Mice, Cysteine-Rich Protein 61

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Promoter function and structure of the growth factorinducible immediate early gene cyr 61

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