A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
Abstract
PTEN/MMAC1/TEP1, encoding a dual-specificity phosphatase, is a tumor suppressor gene which has recently been cloned and mapped to chromosome 10q23.3. We have shown that germline mutations of PTEN are present in individuals with two hamartoma syndromes: Cowden Syndrome, associated with a predisposition to breast and thyroid cancers, and Bannayan-Zonana syndrome. Somatic mutations of PTEN have been reported in a variety of human cancer cell lines, suggesting a potential role for this gene in the pathogenesis of human malignancies. We report the identification of a highly conserved PTEN processed pseudogene, psiPTEN, which shares over 98% homology with the coding region of functional PTEN, and its localisation to chromosome 9p21. The high sequence homology of psiPTEN with the PTEN transcript may potentially lead to misinterpretation when performing mutation analyses based on cDNA templates. Caution should be exerted when using such screening approaches.
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PTEN contains a highly conserved pseudogene, PTENP1, located at chromosome 9p21, with 98% sequence homology with the coding region of functional PTEN.
“Of note, PTEN contains a highly conserved pseudogene, PTENP1, located at chromosome 9p21, with 98% sequence homology with the coding region of functional PTEN (Dahia et al., 1998).”
From Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR (2023) · cites this paper as Dahia et al., 1998
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Soria, J., Lee, H., Lee, J. I., Luo, W., Issa, J. J., Kemp, B. L., Liu, D. D., Kurie, J. M., Mao, L., & Khuri, F. R. (2002) · PubMed · Cited by 406 · see citing works
Mighell, A. J., Smith, N., Robinson, P. A., & Markham, A. F. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01199-6 · Cited by 403 · see citing works
Nelen, M. R., Kremer, H., Konings, I. B. M., Schoute, F., van Essen, A. J., Koch, R., Woods, C. G., Fryns, J., Hamel, B. C. J., Hoefsloot, L. H., et al. (1999) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200289 · Cited by 350 · see citing works
Shan, X., Czar, M. J., Bunnell, S. C., Liu, P., Liu, Y., Schwartzberg, P. L., & Wange, R. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6945-6957.2000 · Cited by 341 · see citing works
Haddadi, N., Lin, Y., Travis, G., Simpson, A. M., Nassif, N. T., & McGowan, E. M. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0803-3 · Cited by 314 · see citing works
PTEN, a unique tumor suppressor gene.
Dahia, P. L. M. (2000) · Endocrine Related Cancer · doi:10.1677/erc.0.0070115 · Cited by 279 · see citing works
Self-citationDahia, P. L. M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.185 · Cited by 270 · see citing works
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García, J. M., Silva, J., Peña, C., García‐Barberán, V., Rodríguez, R., Cruz, M. Á., Cantos, B., Provencio, M., España, P., & Bonilla, F. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20062 · Cited by 224 · see citing works
Knobbe-Thomsen, C. B., Merlo, A. U., & Reifenberger, G. (2002) · Neuro-Oncology · doi:10.1093/neuonc/4.3.196 · Cited by 203 · see citing works
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.
Georgescu, M. M., Kirsch, K. H., Kaloudis, P., Yang, H., Pavletich, N. P., & Hanafusa, H. (2000) · PubMed · Cited by 176 · see citing works
Genomes were forged by massive bombardments with retroelements and retrosequences
Brosius, J. (2000) · Springer eBooks · doi:10.1007/978-94-011-4156-7_23 · Cited by 171 · see citing works
Sasaki, H., Ƶlatescu, M. C., Betensky, R. A., Ino, Y., Cairncross, J. G., & Louis, D. N. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61702-6 · Cited by 157 · see citing works
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Mutter, G. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64656-1 · Cited by 147 · see citing works
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PTEN methylation and expression in glioblastomas
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Mustelin, T. (2002) · Frontiers in bioscience · doi:10.2741/a770 · Cited by 121 · see citing works
Freeburn, R. W., Wright, K. L., Burgess, S., Astoul, E., Cantrell, D. A., & Ward, S. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5441 · Cited by 121 · see citing works
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Weng, L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.3.251 · Cited by 82 · see citing works
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Chen, R., Zhang, M., Liu, W., Chen, H., Cai, T., Xiong, H., Sheng, X., Liu, S., Peng, J., Wang, F., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1207-4 · Cited by 46 · see citing works
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Santos, J., Herranz, M., Fernández, M., Vaquero, C., López, P., & Fernández‐Piqueras, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204297 · Cited by 30 · see citing works
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Kovalenko, T. F., Morozova, K. V., Ozolinya, L. A., Лапина, И. А., & Patrushev, L. I. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-1-43-50 · Cited by 26 · see citing works
Fenic, I., Franke, F. E., Failing, K., Steger, K., & Woenckhaus, J. (2004) · The Journal of Pathology · doi:10.1002/path.1545 · Cited by 26 · see citing works
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Meltzer, S. J., Wolter, M., Trojan, J., Plotz, G., Brieger, A., Raedle, J., & Zeuzem, S. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01954.x · Cited by 23 · see citing works
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Hamilton, J. A., Stewart, L. M. D., Gray, I. C., Gray, N. E., Roberts, K. G., Watson, G., Snary, D., Ajayi, L., & Kaisary, A. V. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1211 · Cited by 22 · see citing works
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Chae, K. S., Ryu, B.-K., Lee, M.-G., Byun, D., & Chi, S.-G. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00147-8 · Cited by 19 · see citing works
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Zhang, C. L., Tada, M., Kobayashi, H., Nozaki, M., Moriuchi, T., & Abe, H. (2000) · Oncogene · doi:10.1038/sj.onc.1203795 · Cited by 17 · see citing works
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Sanchez-Pareja, A., Clément, S., Peyrou, M., Spahr, L., Negro, F., Rubbia‐Brandt, L., & Foti, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i14.3735 · Cited by 13 · see citing works
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Zhang, S., 遠藤, 純., Ichikawa, T., Yoshimura, J., Onda, K., Tanaka, R., Washiyama, K., & Kumanishi, T. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00838.x · Cited by 5 · see citing works
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Lu, X., Gu, Y., Zhu, D., Tan, J., Liu, X., & Zha, X. (2009) · Asian Biomedicine · doi:10.5372/abm.v3i6.264 · Cited by 2 · see citing works
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- Authors
- Dahia, P. L., FitzGerald, M. G., Zhang, X., Marsh, D. J., Zheng, Z., Pietsch, T., von Deimling, A., Haluska, F. G., Haber, D. A., & Eng, C.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Harvard University (US)
- University of Bonn (DE)
- Venue
- Oncogene
- Published
- 1998-05-07
- Volume
- 16
- Issue
- 18
- Pages
- 2403-2406
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2328322201
- Cited by
- 99
- References
- 0
- Citations by year
- 2026: 2 · 2023: 4 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Susan G. Komen for the Cure
- Susan G. Komen
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- PTEN, processed pseudogenes, chromosome 9p21, tumor suppressor, Cowden syndrome, germline mutations, somatic mutations, sequence homology, cancer susceptibility
- MeSH terms
- Amino Acid Sequence, Base Sequence, Chromosome Banding, Chromosomes, Human, Pair 9, Hamartoma Syndrome, Multiple, Humans, Molecular Sequence Data, Phosphoric Monoester Hydrolases, Pseudogenes, Sequence Homology, Nucleic Acid, Species Specificity, Syndrome, Protein Tyrosine Phosphatases, Conserved Sequence, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, PTEN Phosphohydrolase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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What counts as a claim ›How we measure confidence ›How we check this ›
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