Cited by 99PI3K/AKT/mTOR signaling in cancerProtein Tyrosine PhosphatasesCancer Genomics and Diagnostics

A highly conserved processed PTEN pseudogene is located on chromosome band 9p21

Dahia, Patricia LM, FitzGerald, Michael G, Zhang, Xue, Marsh, Debbie J, Zheng, Zimu, Pietsch, Torsten, von Deimling, Andreas, Haluska, Frank G +2 more·1998·Oncogene

Abstract

PTEN/MMAC1/TEP1, encoding a dual-specificity phosphatase, is a tumor suppressor gene which has recently been cloned and mapped to chromosome 10q23.3. We have shown that germline mutations of PTEN are present in individuals with two hamartoma syndromes: Cowden Syndrome, associated with a predisposition to breast and thyroid cancers, and Bannayan-Zonana syndrome. Somatic mutations of PTEN have been reported in a variety of human cancer cell lines, suggesting a potential role for this gene in the pathogenesis of human malignancies. We report the identification of a highly conserved PTEN processed pseudogene, psiPTEN, which shares over 98% homology with the coding region of functional PTEN, and its localisation to chromosome 9p21. The high sequence homology of psiPTEN with the PTEN transcript may potentially lead to misinterpretation when performing mutation analyses based on cDNA templates. Caution should be exerted when using such screening approaches.

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Crossref · 10.1038/sj.onc.1201762

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  • PTEN contains a highly conserved pseudogene, PTENP1, located at chromosome 9p21, with 98% sequence homology with the coding region of functional PTEN.

    “Of note, PTEN contains a highly conserved pseudogene, PTENP1, located at chromosome 9p21, with 98% sequence homology with the coding region of functional PTEN (Dahia et al., 1998).”

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Authors
Dahia, P. L., FitzGerald, M. G., Zhang, X., Marsh, D. J., Zheng, Z., Pietsch, T., von Deimling, A., Haluska, F. G., Haber, D. A., & Eng, C.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Harvard University (US)
  • University of Bonn (DE)
Venue
Oncogene
Published
1998-05-07
Volume
16
Issue
18
Pages
2403-2406
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2328322201
Cited by
99
References
0
Citations by year
2026: 2 · 2023: 4 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
3.94
Type
journal article
Language
en
Open access
closed
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Cancer Society
  • Susan G. Komen for the Cure
  • Susan G. Komen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Keywords
PTEN, processed pseudogenes, chromosome 9p21, tumor suppressor, Cowden syndrome, germline mutations, somatic mutations, sequence homology, cancer susceptibility
MeSH terms
Amino Acid Sequence, Base Sequence, Chromosome Banding, Chromosomes, Human, Pair 9, Hamartoma Syndrome, Multiple, Humans, Molecular Sequence Data, Phosphoric Monoester Hydrolases, Pseudogenes, Sequence Homology, Nucleic Acid, Species Specificity, Syndrome, Protein Tyrosine Phosphatases, Conserved Sequence, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, PTEN Phosphohydrolase

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