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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features
Abstract
Missense mutations in p53 frequently occur at 'hotspot' amino acids which are highly conserved and represent regions of structural or functional importance. Using the p53 mutation database and the p53 DNA sequences for 11 species, we more precisely defined the relationships among conservation, mutation frequency and protein structure. We aligned the p53 sequences codon-by-codon and determined the degree of substitution among them. As a whole, p53 is evolving at an average rate for a mammalian protein-coding gene. As expected, the DNA binding domain is evolving more slowly than the carboxy and amino termini. A detailed map of evolutionary conservation shows that within the DNA binding domain there are repeating peaks and valleys of higher and lower evolutionary constraint. Mutation hotspots were identified by comparing the observed distribution of mutations to the pattern expected from a random multinomial distribution. Seventy-three hotspots were identified; these 19% of codons account for 88% of all reported p53 mutations. Both high evolutionary constraint and mutation hotspots are noted at amino acids close to the protein-DNA interface and at others more distant from DNA, often buried within the core of the folded protein but sometimes on its surface. The results indicate that targeting highly conserved regions for mutational and functional analysis may be efficient strategies for the study of cancer-related genes.
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“TP53 mutations in GBM are mostly point mutations that lead to a high expression of a gain of function (GOF) oncogenic variants of the p53 protein.”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [61]
In the citing paper
“More than 25% of TP53 missense mutations occur within 6 “hotspots” between exons 4–8: R273, R248 (class I, DNA contact mutations) R175, G245, R282, and R249 (class II, conformational mutations) (Figure 3) [61].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [61]
Citations
Cites
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778
Simultaneous Statistical Inference
Miller, R. G. (1981) · Springer series in statistics · doi:10.1007/978-1-4613-8122-8 · Cited by 5,608
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463
Self-citationCrystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559
Fundamentals of molecular evolution
(1991) · Journal of Human Evolution · doi:10.1016/0047-2484(91)90069-8 · Cited by 1,669
Kaghad, M., Bonnet, H., Yang, A., Créancier, L., Biscan, J.-C., Valent, A., Minty, A. J., Chalon, P., Lélias, J.-M., Dumont, X., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80540-1 · Cited by 1,659
Mutational hot spot in the p53 gene in human hepatocellular carcinomas
Hsu, I., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., & Harris, C. C. (1991) · Nature · doi:10.1038/350427a0 · Cited by 1,533
Self-citationA workbench for multiple alignment construction and analysis
Schuler, G. D., Altschul, S. F., & Lipman, D. J. (1991) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340090304 · Cited by 985
p73 is a human p53-related protein that can induce apoptosis
Jost, C. A., Marin, M. C., & Jr, W. G. K. (1997) · Nature · doi:10.1038/38298 · Cited by 948
Carson, M. (1991) · Journal of Applied Crystallography · doi:10.1107/s0021889891007240 · Cited by 809
Flagged first, then by citations
3 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Li W-H. . 1997 Molecular Evolution. Sunderland MA (ed.).. Sinauer Associates, Inc.
- Makalowski W and Boguski MS. . 1998 Proc. Natl. Acad. Sci. USA in press.
Cited by
Sorted by citations
Items 101–198 of 198
Rare Somatic p53 Mutation Identified in Breast Cancer: A Case Report
Šmardová, J., Nemajerová, A., ek, M. T. S., Vagunda, V., & k, J. K. R. I. (2001) · Tumor Biology · doi:10.1159/000050597 · Cited by 25
Mu, Q., Liu, G., Yang, D., Kou, X., Cao, N., Tang, Y., & Miao, P. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00774 · Cited by 24
Kim, J., Jeong, K., Jun, H., Kim, K., Bae, J. M., Song, M. G., Yi, H., Park, S., Woo, G.-U., Lee, D., et al. (2023) · Human Genomics · doi:10.1186/s40246-022-00447-3 · Cited by 26
Bajić, V., Su, B., Lee, H., Kudo, W., Siedlak, S. L., Živković, L., Spremo‐Potparević, B., Djelić, N., Milićević, Z., Singh, A., et al. (2011) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-011-0011-2 · Cited by 24
Mathé, E. A., Olivier, M., Kato, S., Ishioka, C., Vaisman, I. I., & Hainaut, P. L. (2006) · Human Mutation · doi:10.1002/humu.20284 · Cited by 24
Mutation identification DNA analysis system (MIDAS) for detection of known mutations
Bazar, L. S., Collier, G. B., Vanek, P. G., Siles, B. A., Kow, Y. W., Doetsch, P. W., Cunningham, R. P., & Chirikjian, J. G. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19990101)20:6 · Cited by 15
Baumbusch, L. O., Myhre, S., Langerød, A., Bergamaschi, A., Geisler, S. B., Lønning, P. E., Deppert, W., Dornreiter, I., & Børresen‐Dale, A. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-47 · Cited by 23
Structural prediction of protein interactions and docking using conservation and coevolution
Andréani, J., Quignot, C., & Guérois, R. (2020) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1470 · Cited by 23
Identifying Functionally Important Mutations from Phenotypically Diverse Sequence Data
Jensen, K. L., Alper, H. S., Fischer, C. R., & Stephanopoulos, G. N. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.5.3696-3701.2006 · Cited by 21
p53 Expression as a marker of microinvasion in oral squamous cell carcinoma.
Heah, K. G., Hassan, M. I. A., & Huat, S. C. (2011) · PubMed · Cited by 21
Bendig, I., Mohr, N., Krämer, F., & Weber, B. H. F. (2004) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2004.02.017 · Cited by 21
Menzies, G. E., Reed, S. H., Brancale, A., & Lewis, P. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv910 · Cited by 20
Vaites, L. P., Lian, Z., Lee, E. K., Yin, B., DeMicco, A., Bassing, C. H., & Diehl, J. A. (2013) · Oncogene · doi:10.1038/onc.2012.577 · Cited by 20
The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
Jia, S., Zhao, L., Tang, W., & Luo, Y. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4176 · Cited by 21
Ortigosa, S. M., Millán, A. F., & Veramendi, J. (2009) · Transgenic Research · doi:10.1007/s11248-009-9348-y · Cited by 19
Computational analysis of mutation spectra
Rogozin, I. B. (2003) · Briefings in Bioinformatics · doi:10.1093/bib/4.3.210 · Cited by 17
Sugamura, K., Gibbs, J. F., Belicha‐Villanueva, A., Andrews, C., Repasky, E. A., & Hylander, B. L. (2008) · Oncology · doi:10.1159/000151366 · Cited by 17
Towards fast and inexpensive molecular diagnostic: the case of TP53
Jiang, T., Minunni, M., & Mascini, M. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.01.018 · Cited by 17
Ivanov, D. K., Hamby, S. E., Stenson, P. D., Phillips, A. D., Kehrer-Sawatzki, H., Cooper, D. N., & Chuzhanova, N. A. (2011) · Human Mutation · doi:10.1002/humu.21483 · Cited by 16
Nakae, S., Sasaki, H., Hayashi, S., Hattori, N., Kumon, M., Nishiyama, Y., Adachi, K., Nagahisa, S., Hayashi, T., Inamasu, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142750 · Cited by 16
Multimerization of peptide antigens for production of stable immunogens in transgenic plants
Gil-Dones, F., Reytor, E., Pérez-Filgueira, D. M., & Escribano, J. M. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.11.001 · Cited by 15
Functional study of novel PAX9 variants: The paired domain and non‐syndromic oligodontia
Sun, K., Yu, M., Yeh, I., Zhang, L., Liu, H., Cai, T., Feng, H., Liu, Y., & Han, D. K. (2020) · Oral Diseases · doi:10.1111/odi.13684 · Cited by 15
Song, B., Wang, J., Ren, Y., Su, Y.-N., Geng, X., Yang, F., Wang, H., & Zhang, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114773 · Cited by 14
RetractedBao, L., & Cui, Y. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.035 · Cited by 14
Das, S., Duggal, P., Roy, R., Myneedu, V. P., Behera, D., Prasad, H. K., & Bhattacharya, A. (2012) · Scientific Reports · doi:10.1038/srep00297 · Cited by 14
Fernandes, A. D., & Atchley, W. R. (2008) · Journal of Molecular Evolution · doi:10.1007/s00239-008-9124-2 · Cited by 14
Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea.
Budán, F., Varjas, T., Nowrasteh, G., Varga, Z., Boncz, I., Cseh, J., Prantner, I., Tibold, A., Pázsit, E., Göbel, G., et al. (2008) · PubMed · Cited by 13
A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo
Comiskey, D. F., Jacob, A. G., Sanford, B. L., Montes, M., Goodwin, A., Steiner, H. E., Matsa, E., Tapia-Santos, A. S., Bebee, T. W., Grieves, J. L., et al. (2017) · Oncogene · doi:10.1038/onc.2017.282 · Cited by 13
Molecular Mechanisms of Carcinogenesis
Malejka‐Giganti, D., & Tretyakova, N. Y. (2005) · Chemical and functional properties of food components series · doi:10.1201/9781420039269.ch2 · Cited by 12
Low density DNA microarray for detection of most frequent TP53 missense point mutations
Rangel-López, A., Maldonado‐Rodríguez, R., Salcedo–Vargas, M., Espinosa-Lara, J. M., Méndez-Tenorio, A., & Beattie, K. L. (2005) · BMC Biotechnology · doi:10.1186/1472-6750-5-8 · Cited by 13
Defining relative mutational difficulty to understand cancer formation
Shan, L., Yu, J., He, Z., Chen, S., Liu, M., Ding, H., Xu, L., Zhao, J., Yang, A. E., & Jiang, H. (2020) · Cell Discovery · doi:10.1038/s41421-020-0177-8 · Cited by 10
Furukawa, A., Oikawa, S., Harada, K., Sugiyama, H., Hiraku, Y., Murata, M., Shimada, A., & Kawanishi, S. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.08.004 · Cited by 12
Domankevich, V., Opatowsky, Y., Malik, A., Korol, A. B., Frenkel, Z., Manov, I., Avivi, A., & Shams, I. (2016) · BMC Evolutionary Biology · doi:10.1186/s12862-016-0743-8 · Cited by 11
Berge, G., Costea, D. E., Berg, M., Rasmussen, H., Grotterød, I., Lothe, R. A., Mælandsmo, G. M., & Flatmark, K. (2010) · Amino Acids · doi:10.1007/s00726-010-0514-6 · Cited by 12
Complete Models of p53 Better Inform the Impact of Hotspot Mutations
Solares, M. J., & Kelly, D. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315267 · Cited by 11
Zhao, L., Wang, B., Zhao, X., Wu, X., Zhang, Q., Wei, C., Shi, M.-L., Li, Y., Tang, W., Zhang, J., et al. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22737 · Cited by 11
Glazko, G. V., Babenko, V. N., Koonin, E. V., & Rogozin, I. B. (2006) · Biology Direct · doi:10.1186/1745-6150-1-4 · Cited by 11
Damage to cellular and isolated DNA induced by a metabolite of aspirin
Oikawa, S., Kobayashi, H., Tada‐Oikawa, S., Isono, Y., & Kawanishi, S. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.11.016 · Cited by 11
Nakae, S., Kato, T., Murayama, K., Sasaki, H., Abe, M., Kumon, M., Kumai, T., Yamashiro, K., Inamasu, J., Hasegawa, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20951 · Cited by 10
Schaefer, K., Wai, D., Poremba, C., Diallo, R. I., Boecker, W., & Dockhorn‐Dworniczak, B. (2002) · Medical and Pediatric Oncology · doi:10.1002/mpo.10044 · Cited by 10
Maola, K. M. G., Rydén, A., Chowdhury, M. S., Hasan, M. A., & Kazi, J. U. (2011) · Gene · doi:10.1016/j.gene.2011.05.011 · Cited by 9
Modeling the Etiology of p53-mutated Cancer Cells
Perez, R. E., Shen, H., Duan, L., Kim, R. H., Kim, T., Park, N.-H., & Maki, C. G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.724781 · Cited by 9
Gupta, P., Jindal, A., Ahuja, G., Jayadeva, & Sengupta, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102177 · Cited by 10
Frequency and features ofTP53mutation in 30 Chinese patients with sporadic basal cell carcinoma
Wang, Y. M., Huang, Y. S., H., Z., Bu, D., Wang, Y., Tu, P., & Li, H. (2014) · Clinical and Experimental Dermatology · doi:10.1111/ced.12411 · Cited by 9
Theory and Therapy: On the Conceptual Structure of Models in Medical Research
CARRIER, M. J., & Finzer, P. (2010) · Boston studies in the philosophy of science · doi:10.1007/978-90-481-9051-5_6 · Cited by 9
New developments in small molecules targeting p53 pathways in anticancer therapy
Cheok, C. F., & Lane, D. P. (2008) · Drug Development Research · doi:10.1002/ddr.20261 · Cited by 8
Four Novel PAX9 Variants and the PAX9-Related Non-Syndromic Tooth Agenesis Patterns
Liu, H., Liu, H., Su, L., Zheng, J., Feng, H., Liu, Y., Yu, M., & Han, D. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158142 · Cited by 8
Szanyi, I., Lujber, L., Gerlinger, I., Pytel, J., Bauer, M., Csejtei, A., Szele, E., Gombos, K., Kiss, I., Середенин, С. Б., et al. (2007) · PubMed · Cited by 8
Sukhbaatar, N., Bachmayr-Heyda, A., Auer, K., Aust, S., Deycmar, S., Horvat, R., & Pils, D. (2017) · Molecular Case Studies · doi:10.1101/mcs.a001461 · Cited by 8
A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation
Banuelos, J., Shin, S. C., & Lu, N. Z. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.022 · Cited by 7
PROGNOSTIC STATUS OF p53 PROTEIN ACCUMULATION IN CANINE MALIGNANT MAMMARY TUMOURS
Łopuszyński, W., Szczubiał, M., & Komsta, R. (2010) · Cited by 7
Gatti, L., Benedetti, V., Cesare, M. D., Corna, E., Cincinelli, R., Zaffaroni, N., Zunino, F., & Perego, P. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.04.007 · Cited by 7
Evolutionary conservation and mutational spectrum of BMPR2 gene
Wong, W. K. P., Morse, J. H., & Knowles, J. A. (2005) · Gene · doi:10.1016/j.gene.2005.10.025 · Cited by 6
Immunohistochemical expression of protein p53 in neoplasms of the mammary gland in bitches.
Rodo, A., & Malicka, E. (2008) · PubMed · Cited by 6
Alay, M. T. (2025) · Scientific Reports · doi:10.1038/s41598-025-94142-7 · Cited by 5
Dehner, A., Klein, C., Hansen, S., Müller, L., Büchner, J., Schwaiger, M., & Kessler, H. (2005) · Angewandte Chemie · doi:10.1002/ange.200501887 · Cited by 5
Oh, Y., Dung, T. T., Lee, Y., Lee, C., & Kim, M. (2016) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2016.03.015 · Cited by 4
Mechanism of Oxidative DNA Damage Induced by Environmental Carcinogens and Antioxidants
Oikawa, S. (2008) · Genes and Environment · doi:10.3123/jemsge.30.1 · Cited by 4
Hofseth, L. J., Weston, A., & Harris, C. C. (2022) · Wiley eBooks · doi:10.1002/9781119000822.hfcm023.pub2 · Cited by 4
Self-citationKamihira, S., Terada, C., Sasaki, D., Yanagihara, K., Tsukasaki, K., Hasegawa, H., & Yamada, Y. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01211.x · Cited by 3
On the complexity measures of mutation hotspots in human TP53 protein
Ding, Y., Xue, H., Ding, X., Zhao, Y., Zhao, Z., Wang, D., & Wu, J. (2020) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.5143584 · Cited by 3
Szanyi, I., Bauer, M., Gerlinger, I., Járai, T., Göbel, G., Lujber, L., Szabadi, É., Fehér, K., Ember, Á., Ember, I., et al. (2010) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-010-1425-6 · Cited by 3
Liu, L., & Rainbow, A. J. (2004) · Bioscience Reports · doi:10.1007/s10540-005-2792-x · Cited by 3
Online tool for the discrimination of equi-distributions
Pöschel, T., Frömmel, C., & Gille, C. (2003) · BMC Bioinformatics · doi:10.1186/1471-2105-4-58 · Cited by 3
Results of p53 analysis in pediatric malignancies in Poland
Fiszer‐Maliszewska, Ł., Czernik, J., Sawicz-Birkowska, K., Kazanowska, B. J., & Wojciechowska, B. (2003) · Medical and Pediatric Oncology · doi:10.1002/mpo.10277 · Cited by 3
Single‐cell immunohistochemical mutation load assay (SCIMLA) using human paraffin‐embedded tissues
Schlake, G., Liu, Q., Heinmöller, E., Hill, K. A., Weiss, L. M., & Sommer, S. S. (2003) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10193 · Cited by 3
Zeller, S., Spirollari, E., Dicpinigaitis, A. J., Wainwright, J. V., Hanft, S. J., Gandhi, C. D., & Jhanwar‐Uniyal, M. (2023) · Anticancer Research · doi:10.21873/anticanres.16783 · Cited by 2
Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast
Inga, A., Storici, F., & Resnick, M. A. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5963-6_10 · Cited by 2
Ding, T., Liu, H., & Yu, G. (2024) · Children · doi:10.3390/children11121418 · Cited by 1
Wheless, M. C., Stockton, S. S., Soares, H. P., Dayyani, F., Saeed, A., Kim, E. J.-H., Jin, N., Yacoub, G., Florou, V., Ayers, G. D., et al. (2025) · The Oncologist · doi:10.1093/oncolo/oyaf400 · Cited by 1
Adenovirus mediated gene therapy in cell lines derived from canine oral melanoma
Rodrigues, O. A., Antunes, F., Silva, G. R. O., Niitsuma, B. N., da Luz, J. C. D. S., & Strauss, B. E. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1835389 · Cited by 1
Pan-cancer analysis of expressed somatic nucleotide variants in long intergenic non-coding RNA
Ching, T., & Garmire, L. (2018) · Pacific Symposium on Biocomputing · doi:10.1142/9789813235533_0047 · Cited by 1
Analysis of TP53 Gene Mutations in the Korean Patients with Lung Cancer
Jung, S. B., Chang, H. K., Choi, S. C., Shin, K. C., Lee, K.-H., & Jeon, C. (2011) · Laboratory Medicine Online · doi:10.3343/lmo.2011.1.4.6 · Cited by 1
Nemunaitis, J. J., Blend, C., Bien-Willner, G. A., Degele, M., Roth, A., Hayes, S., Plato, L., Guo, A. Y., Nemunaitis, J., Jackson, D., et al. (2015) · Integrative Molecular Medicine · doi:10.15761/imm.1000162 · Cited by 1
Es la muerte importante para la vida
Pérez, F., & Fernando, I. (2002) · Veterinaria · Cited by 1
Silva, G. R. O. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2019.tde-07052019-103754 · Cited by 1
Models Predicting Effects of Missense Mutations in Oncogenesis
Addepalli, K. (2014) · doi:10.13021/mars/7671 · Cited by 1
Hernández, I., Maddison, L. A., Wei, Y., DeMayo, F. J., Petras, T., Li, B., Gingrich, J. R., Rosen, J. M., & Greenberg, N. M. (2003) · PubMed · Cited by 32
Smith, R. G. (2009) · Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)
Granular Association Testing in p53 Multiple Sequence Alignment
Manjunath, R. (2012) · The Atrium (University of Guelph)
Cabral, C. T. S. (2004) · Americanae (AECID Library)
Protein Folding: From Normal Cellular Function to Pathophysiology
Rasool, M., Malik, A., Manan, A., Sultana, M., Qazi, M. H., & Pushparaj, P. N. (2015) · Springer eBooks · doi:10.1007/978-81-322-2467-9_5
Online tool for the discrimination of equi-distributionsPreprint
Poeschel, T., Frömmel, C., & Gille, C. (2004) · arXiv (Cornell University) · doi:10.48550/arxiv.q-bio/0401041
Kim, J., Jeong, K., Jun, H., Kim, K., Yi, H., Park, S., Woo, G.-U., Lee, D., Kim, T.-Y., Lee, K.-H., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1942928/v1
Holstege, H. H., Joosse, S. A., van Oostrom, C. T. M., Nederlof, P. M., de Vries, A., & Jonkers, J. (2023) · doi:10.1158/0008-5472.22380516
Holstege, H. H., Joosse, S. A., van Oostrom, C. T. M., Nederlof, P. M., de Vries, A., & Jonkers, J. (2023) · doi:10.1158/0008-5472.22380516.v1
Resolving p53 to Create Clinically-Relevant Mutation Models
Solares, M. J., Jonaid, G. M., & Kelly, D. F. (2023) · Microscopy and Microanalysis · doi:10.1093/micmic/ozad067.560
Hofseth, L. J., Weston, A., & Harris, C. C. (2017) · Wiley eBooks · doi:10.1002/9781119000822.hfcm023
Self-citationGain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1α in glioblastomaPreprint
Zhang, Y., Yuan, F., Gibert, M. K., Dube, C., Hudson, K., Grello, C., Reon, B. J., Saha, S., Sun, Y., Marcinkiewicz, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676559
Zhou, Y., Zou, L., & Li, Y. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1648420
Guo, Y., Gu, R., Gao, F., Liu, L., Deng, D., Zhang, Q., Wang, L., Liu, Q., Lan, L., & Cang, S. (2025) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s547105
Kim, J., Jeong, K., Jun, H., Kim, K., Bae, J. M., Song, M. G., Yi, H., Park, S., 우고운, Lee, D.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26559497
Exploration and structural modelling of protein interactions using evolutionary information
Quignot, C. (2020) · theses.fr (ABES) · doi:10.70675/c93aba27zbff8z4080za06cze186c92097dc
Metadata
- Authors
- Walker, D. R., Bond, J. P., Tarone, R. E., Harris, C. C., Makalowski, W., Boguski, M. S., & Greenblatt, M. S.
- Affiliations
- National Institutes of Health (US)
- University of Vermont (US)
- Venue
- Oncogene
- Published
- 1999-01-07
- Volume
- 18
- Issue
- 1
- Pages
- 211-218
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2325557141
- Cited by
- 198
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Keywords
- p53, missense mutations, mutational hotspots, evolutionary conservation, protein evolution rate, DNA-binding domain, protein-DNA interface, codon substitution, protein structure, somatic mutations, cancer genes
- MeSH terms
- Chromosome Mapping, Mutation, Protein Conformation, Tumor Suppressor Protein p53, Evolution, Molecular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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