Cited by 198Cancer-related Molecular PathwaysCancer Genomics and DiagnosticsGenomics and Rare Diseases

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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features

Walker, D Roland, Bond, Jeffrey P, Tarone, Robert E, Harris, Curtis C, Makalowski, Wojciech, Boguski, Mark S, Greenblatt, Marc S·1999·Oncogene

DOI 10.1038/sj.onc.1202298

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Abstract

Missense mutations in p53 frequently occur at 'hotspot' amino acids which are highly conserved and represent regions of structural or functional importance. Using the p53 mutation database and the p53 DNA sequences for 11 species, we more precisely defined the relationships among conservation, mutation frequency and protein structure. We aligned the p53 sequences codon-by-codon and determined the degree of substitution among them. As a whole, p53 is evolving at an average rate for a mammalian protein-coding gene. As expected, the DNA binding domain is evolving more slowly than the carboxy and amino termini. A detailed map of evolutionary conservation shows that within the DNA binding domain there are repeating peaks and valleys of higher and lower evolutionary constraint. Mutation hotspots were identified by comparing the observed distribution of mutations to the pattern expected from a random multinomial distribution. Seventy-three hotspots were identified; these 19% of codons account for 88% of all reported p53 mutations. Both high evolutionary constraint and mutation hotspots are noted at amino acids close to the protein-DNA interface and at others more distant from DNA, often buried within the core of the folded protein but sometimes on its surface. The results indicate that targeting highly conserved regions for mutational and functional analysis may be efficient strategies for the study of cancer-related genes.

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A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778
Simultaneous Statistical Inference
Miller, R. G. (1981) · Springer series in statistics · doi:10.1007/978-1-4613-8122-8 · Cited by 5,608
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463
Self-citation
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559
Fundamentals of molecular evolution
(1991) · Journal of Human Evolution · doi:10.1016/0047-2484(91)90069-8 · Cited by 1,669
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers
Kaghad, M., Bonnet, H., Yang, A., Créancier, L., Biscan, J.-C., Valent, A., Minty, A. J., Chalon, P., Lélias, J.-M., Dumont, X., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80540-1 · Cited by 1,659
Mutational hot spot in the p53 gene in human hepatocellular carcinomas
Hsu, I., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., & Harris, C. C. (1991) · Nature · doi:10.1038/350427a0 · Cited by 1,533
Self-citation
A workbench for multiple alignment construction and analysis
Schuler, G. D., Altschul, S. F., & Lipman, D. J. (1991) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340090304 · Cited by 985
p73 is a human p53-related protein that can induce apoptosis
Jost, C. A., Marin, M. C., & Jr, W. G. K. (1997) · Nature · doi:10.1038/38298 · Cited by 948
RIBBONS 2.0
Carson, M. (1991) · Journal of Applied Crystallography · doi:10.1107/s0021889891007240 · Cited by 809

Show all 28 references

Research works printed but not linked: 2

Li W-H. . 1997 Molecular Evolution. Sunderland MA (ed.).. Sinauer Associates, Inc.
Makalowski W and Boguski MS. . 1998 Proc. Natl. Acad. Sci. USA in press.

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Deng, L., Yang, J., Zhao, X. R., Deng, X., Zeng, L., Gu, H., Tang, M., & Cao, Y. (2003) · Cell Research · doi:10.1038/sj.cr.7290163 · Cited by 42
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Yang, Z., Ro, S. W., & Rannala, B. H. (2003) · Genetics · doi:10.1093/genetics/165.2.695 · Cited by 40
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Yonemaru, K., Sakai, H., Murakami, M., Kodama, A., Mori, T., Yanai, T., Maruo, K., & Masegi, T. (2007) · Journal of Veterinary Medical Science · doi:10.1292/jvms.69.271 · Cited by 37
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Xie, T., Zhou, G., Zhao, M., Sano, D., Jasser, S. A., Brennan, R. G., & Myers, J. N. (2013) · The Laryngoscope · doi:10.1002/lary.23846 · Cited by 31
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Murphy, J. A., Barrantes-Reynolds, R., Kocherlakota, R., Bond, J. P., & Greenblatt, M. S. (2004) · Human Mutation · doi:10.1002/humu.20083 · Cited by 31
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Fleckenstein, D., Uphoff, C. C., Drexler, H. G., & Quentmeier, H. (2002) · Leukemia Research · doi:10.1016/s0145-2126(01)00107-2 · Cited by 29
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Otsuka, K., Kato, S., Kakudo, Y., Mashiko, S., Shibata, H., & Ishioka, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.22724 · Cited by 28
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Avivi, A., Ashur‐Fabian, O., Amariglio, N., Nevo, E., & Rechavi, G. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1534 · Cited by 29
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Glazko, G. V., Koonin, E. V., & Rogozin, I. B. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.05.004 · Cited by 28
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Lamolle, G., Marı́n, M., & Álvarez-Valín, F. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.03.004 · Cited by 27
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Li, S., Jiang, T., Li, G., & Wang, Z. (2008) · Neurological Research · doi:10.1179/174313208x297913 · Cited by 25
Role in tumorigenesis of silent mutations in the TP53 gene
Strauss, B. S. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00135-4 · Cited by 25
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Burk, A., Scally, M., Amrine‐Madsen, H., Stanhope, M. J., & Springer, M. S. (2006) · Mammalian Genome · doi:10.1007/s00335-005-0067-2 · Cited by 26

Authors: Walker, D. R., Bond, J. P., Tarone, R. E., Harris, C. C., Makalowski, W., Boguski, M. S., & Greenblatt, M. S.
Affiliations: National Institutes of Health (US)
University of Vermont (US)
ORCID: Tarone, Robert E
Harris, Curtis C
Greenblatt, Marc S
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 1999-01-07
Volume: 18
Issue: 1
Pages: 211-218
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1202298
OpenAlex: W2325557141
Cited by: 198
References: 28
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 7
FWCI: 5.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
Keywords: p53, missense mutations, mutational hotspots, evolutionary conservation, protein evolution rate, DNA-binding domain, protein-DNA interface, codon substitution, protein structure, somatic mutations, cancer genes
MeSH terms: Chromosome Mapping, Mutation, Protein Conformation, Tumor Suppressor Protein p53, Evolution, Molecular

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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features

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