Cited by 179Alcohol Consumption and Health EffectsCell death mechanisms and regulationLiver physiology and pathology

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Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins

Hong, Feng, Kim, Won-Ho, Tian, Zhigang, Jaruga, Barbara, Ishac, Edward, Shen, Xuening, Gao, Bin·2002·Oncogene

DOI 10.1038/sj.onc.1205016

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Abstract

Elevation of serum interleukin-6 (IL-6) levels is always associated with alcoholic liver disease (ALD), but the significance of such elevation is not clear. Here we show that chronic ethanol consumption induces significant apoptosis in the liver of IL-6 (-/-) mice but not IL-6 (+/+) mice. IL-6 (-/-) hepatocytes are more susceptible to ethanol- and tumor necrosis factor alpha- (TNFalpha-) induced apoptotic killing, which can be corrected by IL-6. Expression of both anti-apoptotic (such as Bcl-2 and Bcl-x(L)) and proapoptotic (such as Bax) proteins is markedly elevated in the liver of human ALD and chronically ethanol-fed IL-6 (+/+) mice. On the contrary, induction of Bcl-2 and Bcl-x(L) is not observed in the liver of chronically ethanol-fed IL-6 (-/-) mice, whereas expression of Bax protein remains elevated. Injection of IL-6 markedly induces expression of Bcl-2 and Bcl-x(L) but not Bax in the liver. Finally, high concentrations of ethanol inhibit IL-6-activated anti-apoptotic signal, but increasing the concentrations of IL-6 is able to overcome such inhibitory effect. These findings suggest that elevated serum IL-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6-mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis by induction of Bcl-2 and Bcl-x(L).

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Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
Kovalovich, K., DeAngelis, R. A., Li, W., Furth, E. E., Ciliberto, G., & Taub, R. (2000) · Hepatology · doi:10.1002/hep.510310123 · Cited by 298
Liver regeneration induced by a designer human IL‐6/ sIL‐6R fusion protein reverses severe hepatocellular injury
Galun, E., Zeira, E., Pappo, O., Peters, M., & Rose-John, S. (2000) · The FASEB Journal · doi:10.1096/fj.99-0913com · Cited by 124

Show all 0 references

Research works printed but not linked: 49

Abittan CS, Lieber CS . 1999 Curr. Treat Options Gastroenterol. 2: 72–80 · DOI
Adams JM, Cory S . 2001 Trends Biochem. Sci. 26: 61–66 · DOI
Benedetti A, Brunelli E, Risicato R, Cilluffo T, Jezequel AM, Orlandi F . 1988 J. Hepatol. 6: 137–143 · DOI
Chang YC, Xu YH . 2000 Cell Res. 10: 233–242 · DOI
Chen J, Bao H, Sawyer S, Kunos G, Gao B . 1997 Biochem. Biophys. Res. Commun. 239: 666–669 · DOI
Chen J, Ishac EJ, Dent P, Kunos G, Gao B . 1998 Biochem. J. 334: 669–676 · DOI
Chen J, Kunos G, Gao B . 1999a FEBS Lett. 457: 162–168 · DOI
Chen MC, Hsu TL, Luh TY, Hsieh SL . 2000 J. Biol. Chem. 275: 38794–38801 · DOI
Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML . 1999b J. Biol. Chem. 274: 23013–23019 · DOI
Deaciuc IV, Alappat JM, McDonough KH, D'Souza NB . 1996 Alcohol. Clin. Exp. Res. 20: 293–301 · DOI
Deaciuc IV, Fortunato F, D'Souza N, Hill D, McClain C . 2001 Hepatol. Res. 19: 306–324 · DOI
Diehl AM . 1989 Med. Clin. North Am. 73: 815–830 · DOI
Diehl AM . 1999a Alcohol. Clin. Exp. Res. 23: 1419–1424 · DOI
Diehl AM . 1999b Clin. Biochem. 32: 571–578 · DOI
Ezure T, Sakamoto T, Tsuji H, Lunz III JG, Murase N, Fung JJ, Demetris AJ . 2000 Am. J. Pathol. 156: 1627–1639 · DOI
Fontanilla CV, Faunce DE, Gregory MS, Messingham KA, Durbin EA, Duffner LA, Kovacs EJ . 2000 Alcohol. Clin. Exp. Res. 24: 1392–1399 · DOI
Fuchs D, Gruber A, Uberall F, Wachter H . 1994 Immunol. Today 15: 496 · DOI
Goldin RD, Hunt NC, Clark J, Wickramasinghe SN . 1993 J. Pathol. 171: 73–76 · DOI
Gonzalez-Quintela A, Dominguez-Santalla MJ, Perez LF, Vidal C, Lojo S, Barrio E . 2000 Cytokine 12: 1437–1440 · DOI
Grad J, Zeng X, Boise L . 2000 Curr. Opin. Oncol. 12: 543–549 · DOI
Hall PD . 1994 Alcohol. Suppl. 2: 303–313 · DOI
Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L . 1996 Hepatology 23: 497–505 · DOI
Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH . 2001 Mol. Ther. 3: 683–687 · DOI
Hong F, Nguyrn VA, Gao B . 2001 FASEB J. 15: 1595–1597 · DOI
Hong F, Nguyen VA, Shen X, Kunos G, Gao B . 2000 Biochem. Biophys. Res. Commun. 279: 974–979 · DOI
Kamimura S, Tsukamoto H . 1995 Hepatology 22: 1304–1309 · DOI
Kim W, Hong F, Jaruga B, Hu Z, Fan S, Liang J, Gao B . 2001 FASEB J. 15: in press · DOI
Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G, Taub R . 2001 J. Biol. Chem. 276: 26605–26613 · DOI
Kuo ML, Chuang SE, Lin MT, Yang SY . 2001 Oncogene 20: 677–685 · DOI
Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, Ishii H . 1997 Hepatology 25: 368–378 · DOI
Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A . 1996 Nat. Med. 2: 80–86 · DOI
Laso FJ, Iglesias-Osma C, Ciudad J, Lopez A, Pastor I, Orfao A . 1999 Alcohol. Clin. Exp. Res. 23: 1306–1311 · DOI
Maddrey WC . 2000 Clin. Liver Dis. 4: 115–131 vii · DOI
Martinez F, Abril ER, Earnest DL, Watson RR . 1992 Alcohol 9: 455–458 · DOI
McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D . 1999 Semin. Liver Dis. 19: 205–219 · DOI
Mi LJ, Mak KM, Lieber CS . 2000 Alcohol. Clin. Exp. Res. 24: 207–212 · DOI
Panesar N, Tolman K, Mazuski JE . 1999 J. Surg. Res. 85: 251–258 · DOI · Paper page
Pastorino JG, Hoek JB . 2000 Hepatology 31: 1141–1152 · DOI
Pennington HL, Hall PM, Wilce PA, Worrall S . 1997 J. Gastroenterol. Hepatol. 12: 305–313 · DOI
Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FY, Diehl AM . 1999 Hepatology 29: 1131–1138 · DOI
Rollwagen FM, Yu ZY, Li YY, Pacheco ND . 1998 Clin. Immunol. Immunopathol 89: 205–213 · DOI
Sasaki Y, Wands JR . 1994 Biochem. Biophys. Res. Commun. 199: 403–409 · DOI
Slomiany A, Piotrowski E, Grabska M, Piotrowski J, Slomiany BL . 1999 Alcohol. Clin. Exp. Res. 23: 334–343 · DOI
Tuma DJ, Todero SL, Barak-Bernhagen M, Sorrell MF . 1996 Alcohol. Clin. Exp. Res. 20: 579–583 · DOI
Walsh K, Alexander G . 2000 Postgrad. Med. J. 76: 280–286 · DOI
Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA . 2000 Am. J. Respir. Cell. Mol. Biol. 22: 535–542 · DOI
Yacoub LK, Fogt F, Griniuviene B, Nanji AA . 1995 Alcohol. Clin. Exp. Res. 19: 854–859 · DOI
Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, Thurman RG . 1999 Gastroenterology 117: 942–952 · DOI
Zhao M, Laissue JA, Zimmermann A . 1997 Virchows Arch 431: 337–344 · DOI

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Peng, H.-C., Chen, Y.-L., Chen, J.-R., Yang, S.-S., Huang, K.-H., Wu, Y.-C., Lin, Y.-H., & Yang, S.-C. (2011) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.02.006 · Cited by 24
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Changes in the hepatic gene expression profile in a rat model of chronic ethanol treatment
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Fetal Alcohol Exposure: The Common Toll
Nakhoul, M. R., Seif, K. E., Haddad, N., & Haddad, G. E. (2017) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000257 · Cited by 23
“Furthermore, ethanol has been found to be involved in other apoptotic signaling pathways, including Fas/ Fas-L [14], Bcl-2 family [15], and caspase signaling systems [16].”
Background
Rebuilding the balance of STAT1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice.
Wu, X.-X., Sun, Y., Guo, W.-J., Gu, Y.-H., Wu, X., Tan, R.-X., & Xu, Q. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.006 · Cited by 20
“hepatoxins, including CCl4, TNF-a, alcohol and Fas ligand [35,36].”
Background
S‐allyl‐l‐cysteine (SAC) protects hepatocytes from alcohol‐induced apoptosis
Chen, P., Hu, M.-D., Liu, F., Yu, H., & Chen, C. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12684 · Cited by 19
Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver
Bloomer, S. A., Kregel, K. C., & Brown, K. E. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.07.012 · Cited by 19
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Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart
Kamiński, K., Kożuch, M., Bonda, T., Stepaniuk, M., Waszkiewicz, E., Chyczewski, L., Musiał, W. J., & Winnicka, M. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70093-3 · Cited by 19
“Similar results have been described in enterocytes during ischemia [21], in pulmonary epithelium after hyperoxia [25] and in hepatocytes after alcohol exposition [7] or Fas treatment [15].”
Result
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Selzner, M., Graf, R., & Clavien, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00811-4 · Cited by 16
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Dissanayake, S., Khan, N., Shahin, A., Wijesinghe, S., & Lukic, M. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01519.x · Cited by 19
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Lee, D.-H., Kim, D. H., Hwang, C. J., Song, S., Han, S., Kim, Y., Yoo, H.-S., Jung, Y.-S., Kim, S., Yoon, D., et al. (2015) · Clinical science · doi:10.1042/cs20140576 · Cited by 16
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Ko, Y.-E., Yoon, S., Ly, S., Kim, J.-H., Sohn, K.-Y., & Kim, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26299 · Cited by 15
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Wang, X.-Z., Zhang, L.-Y., & Jiang, Z. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3115 · Cited by 15
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Chiou, Y., Chyau, C.-C., Li, T., Kuo, C.-F., Kang, Y.-Y., Chen, C., & Ko, W. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1779850 · Cited by 11
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Wang, J., Chen, R., Tang, S.-W., Lv, X., Wu, S.-S., Zhang, Y., Xia, Y.-Y., Gao, P.-P., Tu, D.-H., Chen, D.-F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118862 · Cited by 12
Vitamin B12 and hepatic enzyme serum levels correlate with interleukin-6 in alcohol-dependent individuals without liver disease
Liappas, I., Nicolaou, C., Chatzipanagiotou, S., Tzavellas, E., Piperi, C., Papageorgiou, C., Boufidou, F., Bagos, P. G., & Soldatos, C. R. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.03.002 · Cited by 11
“These findings suggest that elevated serum IL-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis [34].”
Background
Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
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Relja, B., Wilhelm, K., Wang, M.-H., Henrich, D., Marzi, I., & Lehnert, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/983427 · Cited by 11
Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease
Martínez‐Castillo, M., Altamirano-Mendoza, I., Sánchez-Valle, S., García-Islas, L., Sánchez-Barragán, M., Hernandez-Santillan, M., Hernández-Barragán, A., Pérez-Hernández, J. L., la Tijera, F. H., & Gutiérrez‐Reyes, G. (2023) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2023.03.003 · Cited by 11
Interleukin‐6 promotes 2‐deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes
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Molecular markers for early stratification of disease severity and progression in COVID-19
Kashyap, A., Sebastian, S., NarayanaSwamy, S. R. K., Raksha, K., Krishnamurthy, H., Krishna, B., D'Souza, G., Idiculla, J., & Vyas, N. (2022) · medRxiv · doi:10.1093/biomethods/bpac028 · Cited by 7
“We recruited a total of 42 patients in this study, 5 patients with alcoholic liver disease or HIV were excluded from molecular analysis as these conditions are known to influence the molecular profiles of interest independently from SARS-CoV-2 infection or severity status [5, 6] (Fig.”
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Discrepant roles of CpG ODN on acute alcohol-induced liver injury in mice.
Wang, Z.-J., Wu, X.-L., Zhang, Y., Zhou, L., Li, L., Yu, Y., & Wang, L.-Y. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.01.007 · Cited by 7
Nutritional and microbiota-based therapeutic interventions for alcohol-associated liver disease: From pathogenesis to therapeutic insights
Rangra, S., Rana, D., Prajapati, A., Benival, D. M., Dwivedi, P., & Mandoli, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122852 · Cited by 7
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Yang, Y.-S., Takahara, K., Kumrungsee, T., Kimoto, A., Shimamoto, F., & Kato, N. (2019) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.65.443 · Cited by 4
Bio-informatics based analysis of genes implicated in alcohol mediated liver injury.
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Henderson, C. C., Zhang, Z., Manson, S. R., Riehm, J. J., Kataoka, M., Flye, M., Garbow, J., You, M., & Weintraub, S. (2005) · Oncogene · doi:10.1038/sj.onc.1208887 · Cited by 4
“Additionally, these results strongly suggest that the increase in hepatocellular Bcl-xL expression that occurs in response to chronic ethanol abuse (Hong et al., 2002) affords further protection against injury.”
BackgroundInfluential
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Bajo, M., Gandhi, P. J., Fei, S. S., Yu, Y., Gao, L., Khadka, R., Blanton, M. B., Messaoudi, I., Warden, A. S., Mayfield, R. D., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106227 · Cited by 2
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Irtiza, S. (2019) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v7i2.143 · Cited by 1
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DeGroat, A. R., & Peterson, J. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.887.12 · Cited by 1
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Sastre, J., Miñana, J. B., Pallardó, F., & Viña, J. (2004) · Elsevier eBooks · doi:10.1016/b978-012564370-2/50064-7 · Cited by 1
Purinergic–immune crosstalk in alcohol-induced neuroinflammation is modulated by e-cigarette co-exposure
Togre, N. S., Carpio‐Cano, F. D., Mekala, N. K., Winfield, M., Sriram, U., Rom, S., & Persidsky, Y. (2026) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2026-0013
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Nuclear receptor ERRγ acts as a key transcriptional regulator of hepatic LCN2 expression in CCl4-induced acute liver injury.
Choi, B.-Y., Jung, Y., Park, W.-R., Kim, Y.-H., Lee, C.-H., Choi, H.-S., & Kim, D.-K. (2025) · Tissue & Cell · doi:10.1016/j.tice.2025.103250
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Tomasiuk, R., & Wiacek, M. (2025) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2025.153262
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Impact of chronic ethanol consumption and SARS-COV-2 on the liver and intestine: A pilot dose-response study in mice
Ghare, S. S., Warner, D. R., Warner, J. B., Chilton, P. M., Lee, J., Zhang, J.-W., Wang, M., Hardesty, J. E., Treves, R. S., Gabbard, J., et al. (2025) · Alcohol, clinical & experimental research · doi:10.1111/acer.15528
Neoplastic Effects of Endogenous Alcohol in Carcinogenesis Process of Hepatocarcinoma
Udristioiu, A., Martin, A., Martin, L., Giubelan, A., Udristioiu, D., Mălăescu, D., Daniela, P., Nica-Badea, D., & Ungureanu, D. (2022) · European Journal of Clinical Medicine · doi:10.24018/clinicmed.2022.3.3.203
Contribuição do componente C5 do sistema complemento em modelo experimental murino de doença hepática alcoólica.
Bavia, L. (2013) · doi:10.11606/t.42.2013.tde-15032014-111816
Characterization of Adipose Tissue Inflammation in Alcoholic Liver Disease
Fulham, M. A. (2017) · doi:10.13028/m2v968
117 – Genetically Engineered Animals in Alcohol Research
Werner, D., Chandra, D., & Homanics, G. (2004) · Elsevier eBooks · doi:10.1016/b978-012564370-2/50119-7

Authors: Hong, F., Kim, W.-H., Tian, Z., Jaruga, B., Ishac, E., Shen, X., & Gao, B.
Affiliations: National Institutes of Health (US)
University of Science and Technology of China (CN)
Virginia Commonwealth University (US)
Corresponding author: Gao, Bin
ORCID: Kim, Won-Ho
Tian, Zhigang
Gao, Bin
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2002-01-03
Volume: 21
Issue: 1
Pages: 32-43
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1205016
OpenAlex: W2057210516
Cited by: 179
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 11
FWCI: 7.68
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01aa012637-03)
National Institute on Alcohol Abuse and Alcoholism (R01 AA 12637)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: interleukin-6, ethanol consumption, alcoholic liver disease, hepatocyte apoptosis, Bcl-2, Bcl-xL, Bax, TNF-α, anti-apoptotic signaling, IL-6 knockout mice
MeSH terms: Ethanol, Alcoholism, Animals, Body Weight, Cells, Cultured, Gene Expression Regulation, Genotype, Humans, Liver, Liver Diseases, Alcoholic, Male, Organ Size, Tumor Necrosis Factor-alpha, Interleukin-6, Apoptosis, Mice, Knockout, Proto-Oncogene Proteins c-bcl-2, Genes, bcl-2, Genetic Predisposition to Disease, Hepatocytes, bcl-X Protein, Mice

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Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins

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