Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069

Identification of the breast cancer susceptibility gene BRCA2

Wooster, R., Bignell, G. R., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S. G., Gumbs, C. E., Micklem, G., et al. (1995) · Nature · doi:10.1038/378789a0 · Cited by 3,645

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

Ford, D., Easton, D., Stratton, M. R., Narod, S., Goldgar, D., Devilee, P., Bishop, D., Weber, B., Lenoir, G., Chang-Claude, J., et al. (1998) · American Journal of Human Genetics · doi:10.1086/301749 · Cited by 2,766

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544

Risks of cancer in BRCA1-mutation carriers

FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850 · cited 1×

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007

p53, BRCA1 and Breast Cancer Chemoresistance

Scata, K. A., & El‐Deiry, W. S. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74039-3_5 · Cited by 41

Germline Mutations in theBRCA2Gene and Susceptibility to Hereditary Prostate Cancer

Agalliu, I., Kwon, E. M., Zadory, D., McIntosh, L. M., Thompson, J., Stanford, J. L., & Ostrander, E. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2164 · Cited by 41

A comprehensive literature review and meta‐analysis of the prevalence of pan‐cancer BRCA mutations, homologous recombination repair gene mutations, and homologous recombination deficiencies

Shao, C., Wan, J., Lam, F. C., Tang, H., Marley, A. R., Song, Y., Miller, C., Brown, M., Han, J., & Adeboyeje, G. (2022) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22505 · Cited by 42

The Influence of BRCA1/BRCA2 Mutations on Toxicity Related to Chemotherapy and Radiotherapy in Early Breast Cancer Patients

Huszno, J., Budryk, M., Kołosza, Z., & Nowara, E. (2013) · Oncology · doi:10.1159/000354834 · Cited by 40

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein

Alshareeda, A. T., Negm, O. H., Aleskandarany, M. A., Green, A. R., Nolan, C. C., TigHhe, P. J., Madhusudan, S., Ellis, I. O., & Rakha, E. A. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3915-8 · Cited by 41

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent

Sizemore, S. T., Mohammad, R., Sizemore, G. M., Nowsheen, S., Yu, H., Ostrowski, M. C., Chakravarti, A., & Xia, F. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0106 · Cited by 40

Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat?

Toss, A., Venturelli, M., Peterle, C., Piacentini, F., Cascinu, S., & Cortesi, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010085 · Cited by 38

Gynecologic Cancer, Cancer Stem Cells, and Possible Targeted Therapies

Keyvani, V., Riahi, E., Yousefi, M., Esmaeili, S., Shafabakhsh, R., Hasan‐Abad, A. M., Mahjoubin‐Tehran, M., Hamblin, M. R., Mollazadeh, S., & Mirzaei, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823572 · Cited by 36

Gene Expression Profiling of Breast Cancer in Relation to Estrogen Receptor Status and Estrogen-Metabolizing Enzymes: Clinical Implications

Kristensen, V. N., Sørlie, T., Geisler, J., Langerød, A., Yoshimura, N., Kåresen, R., Harada, N., Lønning, P. E., & Børresen‐Dale, A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.878s.11.2 · Cited by 36

Prostate Cancer Germline Variations and Implications for Screening and TreatmentPreprint

Dias, A., Kote‐Jarai, Z., Mikropoulos, C., & Eeles, R. A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a030379 · Cited by 37

Clinical relevance of normal and tumour cell radiosensitivity in BRCA1/BRCA2 mutation carriers: A review

Bernier, J., & Poortmans, P. M. (2014) · The Breast · doi:10.1016/j.breast.2014.12.003 · Cited by 34

Chromosomal aberrations involving telomeres in BRCA1 deficient human and mouse cell lines

Al-Wahiby, S., & Slijepčević, P. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084208 · Cited by 34

Detection of genetic instability at HER-2/neu and p53 loci in breast cancer cells sing Comet–FISH

Kumaravel, T. S., & Bristow, R. G. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-5780-0 · Cited by 34

Radiobiology of Breast Cancer

Tutt, A. N. J., & Yarnold, J. R. (2005) · Clinical Oncology · doi:10.1016/j.clon.2005.11.011 · Cited by 33

The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis

Chun, C., Wu, Y., Lee, S., Williamson, E. A., Reinert, B. L., Jaiswal, A. S., Nickoloff, J. A., & Hromas, R. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1151585 · Cited by 32

Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing

Smith, L. J., Wright, J. B., Clark, G., Ul-Hasan, T., Jin, X., Fong, A., Chandra, M., Martin, T. S., Rubin, H. L., Knowlton, D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802343115 · Cited by 33

Breast Cancer Predisposition Genes and Synthetic Lethality

Neiger, H. E., Siegler, E. L., & Shi, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115614 · Cited by 33

TUSC4 functions as a tumor suppressor by regulating BRCA1's stability via the E3 ubiquitination pathway

Peng, Y., Dai, H., Wang, E., Lin, C. C.-J., Mo, W., Peng, G., & Lin, S.-Y. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2315 · Cited by 34

Olaparib and enzalutamide synergistically suppress HCC progression via the AR‐mediated miR‐146a‐5p/BRCA1 signaling

Zhao, J., Sun, Y., Lin, H. M., Chou, F.-J., Xiao, Y., Jin, R., Cai, X., & Chang, C. (2020) · The FASEB Journal · doi:10.1096/fj.201903045rr · Cited by 31

Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens

Srivatsa, S., Montazeri, H., Bianco, G., Coto‐Llerena, M., Marinucci, M., Ng, C. K. Y., Piscuoglio, S., & Beerenwinkel, N. (2022) · Nature Communications · doi:10.1038/s41467-022-35378-z · Cited by 29

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nowsheen, S., Aziz, K., Luo, K., Deng, M., Qin, B., Yuan, J., Jeganathan, K. B., Yu, J., Zhang, H., Ding, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05161-0 · Cited by 31

The landscape of genetic aberrations in myxofibrosarcoma

Takeuchi, Y., Yoshida, K., Halik, A., Kunitz, A., Suzuki, H., Kakiuchi, N., Shiozawa, Y., Yokoyama, A., Inoue, Y., Hirano, T., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34051 · Cited by 30

Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer

Sharbeen, G. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00010 · Cited by 30

Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer

Sengodan, S. K., Sreelatha, K. H., Nadhan, R., & Srinivas, P. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.01.008 · Cited by 30

Molecular biology of gynecological cancer

Sonoda, K. (2015) · Oncology Letters · doi:10.3892/ol.2015.3862 · Cited by 29

Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues

Liu, X., Cao, L., Ni, J., Liu, N., Zhao, X., Wang, Y., Zhu, L., WANG, L., Wang, J., Yue, Y., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2124 · Cited by 29

Microfluidics: Rapid Diagnosis for Breast Cancer

Panesar, S., & Neethirajan, S. R. (2016) · Nano-Micro Letters · doi:10.1007/s40820-015-0079-8 · Cited by 30

Is breast conservation superior to mastectomy in early stage triple negative breast cancer?

Saifi, O., Chahrour, M. A., Li, Z., Hoballah, J., Panoff, J., Vallow, L. A., & Zeidan, Y. H. (2022) · The Breast · doi:10.1016/j.breast.2022.02.006 · Cited by 28

Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma

Zhang, Z. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i12.1968 · Cited by 30

Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer (Review)

Wu, N., Zhang, J., Zhao, J., Mu, K., Zhang, J., Jin, Z., Yu, J., & Liu, J. (2018) · Oncology Letters · doi:10.3892/ol.2018.9290 · Cited by 30

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation‐induced gene activation of p21 or Mdm2

Hill, D. A., de la Serna, I. L., Veal, T. M., & Imbalzano, A. N. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20003 · Cited by 27

Germline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and Nigeria

Wang, S., Pitt, J. J., Zheng, Y., Yoshimatsu, T. F., Gao, G., Sanni, A., Oluwasola, O., Ajani, M., Fitzgerald, D., Odetunde, A., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32498 · Cited by 27

Activation of DNA damage response signaling in mammalian cells by ionizing radiation

Ghosh, S., & Ghosh, A. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1876853 · Cited by 28

BRCA-Mutated Pancreatic Cancer: From Discovery to Novel Treatment Paradigms

Marciano, N. D., Kroening, G., Dayyani, F., Zell, J. A., Lee, F.-C., Cho, M. T., & Valerin, J. B. (2022) · Cancers · doi:10.3390/cancers14102453 · Cited by 27

The DNA damage response - from cell biology to human disease

Lam, F. C. (2022) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.61 · Cited by 29

T1-2N0M0 Triple-Negative Breast Cancer Treated With Breast-Conserving Therapy Has Better Survival Compared to Mastectomy: A SEER Population-Based Retrospective Analysis

Li, H., Chen, Y., Wang, X., Tang, L., & Guan, X. (2019) · Clinical Breast Cancer · doi:10.1016/j.clbc.2019.05.011 · Cited by 27

Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target

Goyal, G., Fan, T., & Silberstein, P. T. (2016) · Familial Cancer · doi:10.1007/s10689-016-9883-7 · Cited by 28

Improved Therapeutic Window in BRCA -mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition

Zhong, H., Chen, C., Tammali, R., Breen, S., Zhang, J., Fazenbaker, C. A., Kennedy, M., Conway, J., Higgs, B. W., Holoweckyj, N., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0314 · Cited by 23

Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma

Johansson, P., Nathan, V., Bourke, L. M., Palmer, J., Zhang, T.-W., Symmons, J., Howlie, M., Patch, A., Read, J., Holland, E., et al. (2019) · Melanoma research · doi:10.1097/cmr.0000000000000613 · Cited by 21

Co-expression of antioxidant enzymes with expression of p53, DNA repair, and heat shock protein genes in the gamma ray-irradiated hermaphroditic fish Kryptolebias marmoratus larvae

Rhee, J., Kim, B., Kim, R., Seo, J. S., Kim, I., Lee, Y.-M., & Lee, J. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.05.006 · Cited by 26

Clinical Application of Micronucleus Test: A Case-Control Study on the Prediction of Breast Cancer Risk/Susceptibility

Bolognesi, C., Bruzzi, P., Gismondi, V., Volpi, S., Viassolo, V., Pedemonte, S., & Varesco, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112354 · Cited by 26

Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer

Devun, F., Bousquet, G., Biau, J., Herbette, A., Roulin, C., Berger, F., Sun, J., Robine, S., & Dutreix, M. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0483-x · Cited by 26

Diagnostic Chest X-Rays and Breast Cancer Risk before Age 50 Years for BRCA1 and BRCA2 Mutation Carriers

John, E. M., McGuire, V. M., Thomas, D. C., Haile, R. W., Özçelik, H., Milne, R. L., Felberg, A., West, D. W., Miron, A., Knight, J. A., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0189 · Cited by 26

BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far

Sharma, B., Kaur, R. P., Raut, S., & Munshi, A. (2018) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2018.01.001 · Cited by 31

DNA methylation in genes associated with the evolution of ageing and disease: A critical review

Auley, M. T. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101488 · Cited by 25

A Review of Breast Cancer Risk Factors in Adolescents and Young Adults

McVeigh, U. M., Tepper, J. W., & McVeigh, T. P. (2021) · Cancers · doi:10.3390/cancers13215552 · Cited by 29

Beyond BRCA: The Emerging Significance of DNA Damage Response and Personalized Treatment in Pancreatic and Prostate Cancer Patients

Dalmasso, B., Puccini, A., Catalano, F., Borea, R., Iaia, M. L., Bruno, W., Fornarini, G., Sciallero, S., Rebuzzi, S. E., & Ghiorzo, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094709 · Cited by 25

DNA damage induced by mammography in high family risk patients: Only one single view in screening

Colin, C., & Foray, N. (2011) · The Breast · doi:10.1016/j.breast.2011.12.003 · Cited by 25

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Ha, K., Ma, C., Han, L., Tang, L., Lian, Z., Zhao, F., Li, J.-M., Zhen, B., Pei, H., Han, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15751 · Cited by 25

Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues

Vaca‐Paniagua, F., Álvarez-Gómez, R. M., Maldonado-Martínez, H. A., Pérez‐Plasencia, C., Fragoso‐Ontiveros, V., Lasa-Gonsebatt, F., Herrera, L. A., de León, D. F. C., Bargalló‐Rocha, E., Mohar, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126762 · Cited by 25

The Preventive Intervention of Hereditary Breast Cancer

Cao, A., Huang, L., & Shao, Z. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6020-5_3 · Cited by 25

Radiation induced breast cancer risk in BRCA mutation carriers from low-dose radiological exposures: a systematic review

Colin, C., Foray, N., Leo, G. D., & Sardanelli, F. (2017) · Radioprotection · doi:10.1051/radiopro/2017034 · Cited by 23

Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells

Liao, B., Zhang, Y., Sun, Q., & Jiang, P. (2017) · Cancer Medicine · doi:10.1002/cam4.1278 · Cited by 23

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development

Maresca, L., Lodovichi, S., Lorenzoni, A., Cervelli, T., Monaco, R., Spugnesi, L., Tancredi, M., Falaschi, E., Zavaglia, K. M., Landucci, E., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00397 · Cited by 25

BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression

Zhang, X., & Li, R. (2018) · Cancers · doi:10.3390/cancers10120513 · Cited by 25

Rec2 Interplay with both Brh2 and Rad51 Balances Recombinational Repair in Ustilago maydis

Kojić, M., Zhou, Q., Lisby, M., & Holloman, W. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.678-688.2006 · Cited by 23

Combinatorial Approaches to Enhance DNA Damage following Enzyme-Mediated Depletion of L-Cys for Treatment of Pancreatic Cancer

Saha, A., Zhao, S., Chen, Z., Georgiou, G., Stone, E. M., Kidane, D., & DiGiovanni, J. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.10.016 · Cited by 24

The role and clinical significance of DNA damage response and repair pathways in primary brain tumors

Santivasi, W. L., & Xia, F. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-10 · Cited by 22

BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

Zhang, X., Wang, Y., Chiang, H.-C., Hsieh, Y.-P., Lu, C., Park, B. H., Jatoi, I., Jin, V. X., Hu, Y., & Li, R. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1132-1 · Cited by 22

Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?

Ree, A. H., Bratland, Å., Nome, R. V., Stokke, T., Fodstad, Ø., & Andersson, Y. (2004) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2004.07.002 · Cited by 23

GENETIC SUSCEPTIBILITY TO RADIOGENIC CANCER IN HUMANS

Allan, J. M. (2008) · Health Physics · doi:10.1097/01.hp.0000326339.06405.ea · Cited by 22

Targeting Homologous Recombination Repair in Cancer

Willers, H., Pfäffle, H. N., & Zou, L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10007-1 · Cited by 21

PARP Inhibitors and Haematological Malignancies—Friend or Foe?

Skelding, K. A., & Lincz, L. F. (2021) · Cancers · doi:10.3390/cancers13215328 · Cited by 20

GLI1-targeting drugs induce replication stress and homologous recombination deficiency and synergize with PARP-targeted therapies in triple negative breast cancer cells

Mani, C., Tripathi, K. K., Omy, T. R., Reedy, M. B., Manne, U., & Palle, K. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166300 · Cited by 20

Ionizing Radiation: Biologic Effects and Essential Cell Biology

Alqabandi, M. Y., & Alshammari, J. (2022) · Springer eBooks · doi:10.1007/978-3-030-96252-4_2 · Cited by 20

Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer

Jang, A., Sartor, O. A., Barata, P. C., & Paller, C. J. (2020) · Cancers · doi:10.3390/cancers12113467 · Cited by 20

Molecular Logic Underlying Chromosomal Translocations, Random or Non-Random?

Lin, C., Yang, L., & Rosenfeld, M. G. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-394280-7.00015-4 · Cited by 21

Mammographic screening in BRCA1 mutation carriers postponed until age 40: Evaluation of benefits, costs and radiation risks using models

Obdeijn, I.-M., Heijnsdijk, E. A. M., Hunink, M. G. M., Tilanus‐Linthorst, M. M. A., & de Koning, H. J. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.05.012 · Cited by 20

Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae

Lodovichi, S., Bellè, F., Cervelli, T., Lorenzoni, A., Maresca, L., Cozzani, C., Caligo, M. A., & Galli, A. (2019) · Mutagenesis · doi:10.1093/mutage/gez043 · Cited by 19

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

Zhou, Z., Huang, F., Shrivastava, I. H., Zhu, R., Luo, A., Hottiger, M. O., Bahar, İ., Liu, Z., Cristofanilli, M., & Wan, Y. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012391 · Cited by 19

Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

Hughes, D. J. (2008) · Familial Cancer · doi:10.1007/s10689-008-9181-0 · Cited by 18

The efficacy of trabectedin in treating ovarian cancer

Teplinsky, E., & Herzog, T. J. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1285282 · Cited by 18

DNA Strand Breaks in Mitotic Germ Cells of Caenorhabditis elegans Evaluated by Comet Assay

Park, S., Choi, S., & Ahn, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2206 · Cited by 18

RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer

Walens, A., Alsten, S. C. V., Olsson, L. T., Smith, M. A., Lockhart, A., Gao, X., Hamilton, A. M., Kirk, E. L., Love, M. I., Gupta, G. P., et al. (2022) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-0590 · Cited by 18

Breast Cancer Stem Cells and Tumor Suppressor Genes

Hwang‐Verslues, W. W., Chang, K., Lee, E. Y.-H. P., & Lee, W. (2008) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(08)60188-6 · Cited by 18

DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer

Scott, R. J. (2004) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-2-1-37 · Cited by 17

Mammographic screening for young women with a family history of breast cancer: knowledge and views of those at risk

for the PIMMS Study Management Group, Tyndel, S., Clements, A., Bankhead, C. R., Henderson, B. J., Brain, K. E., Watson, E. K., & Austoker, J. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604672 · Cited by 16

Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer

Sassu, C. M., Palaia, I., Boccia, S. M., Caruso, G., Perniola, G., Tomao, F., Donato, V. D., Musella, A., & Muzii, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413650 · Cited by 16

Spontaneous and Irradiation-Induced Tumor Susceptibility in Brca2 Germline Mutant Mice and Cooperative Effects with a p53 Germline Mutation

McAllister, K. A., Houle, C. D., Malphurs, J., Ward, T., Collins, N. K., Gersch, W., Wharey, L., Seely, J. C., Betz, L., Bennett, L. M., et al. (2006) · Toxicologic Pathology · doi:10.1080/01926230600611794 · Cited by 17

BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair

Ismail, I. H., Dronyk, A., Hu, X., Hendzel, M. J., & Shaw, A. R. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1121322 · Cited by 16

Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer

Lev, A., Deihimi, S., Shagisultanova, E. I., Xiu, J., Lulla, A. R., Dicker, D. T., & El‐Deiry, W. S. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1364323 · Cited by 16

miR4673 improves fitness profile of neoplastic cells by induction of autophagy

Dökümcü, K., Simonian, M. R., & Farahani, R. H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1088-6 · Cited by 16

OVCA1: emerging as a bona fide tumor suppressor: Figure 1.Preprint

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Tiong, K.-L., & Yeang, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-29861-1 · Cited by 15

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