Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

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Identification of the breast cancer susceptibility gene BRCA2

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Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

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Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

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Risks of cancer in BRCA1-mutation carriers

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Gatekeepers and caretakers

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BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

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Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.

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The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2

Lakhani, S. R., van de Vijver, M. J., Jacquemier, J. D., Anderson, T. J., Osin, P., McGuffog, L., & Easton, D. F. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.09.023 · Cited by 841

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

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Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

Davies, A. A., Masson, J., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., & West, S. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00175-7 · Cited by 720

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

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Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

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Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

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Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 646

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635

Pattern formation by local self-activation and lateral inhibition

Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Bhattacharyya, A., Ear, U., Koller, B. H., Weichselbaum, R. R., & Bishop, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000276200 · Cited by 584

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

Harkin, D. P., Bean, J. M., Miklos, D. B., Song, Y., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80769-2 · Cited by 558

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512

BRCA1 is a component of the RNA polymerase II holoenzyme

Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., & Parvin, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5605 · Cited by 454

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

Wilson, C., Ramos, L., Villaseñor, M. R., Anders, K. H., Press, M. F., Clarke, K., Karlan, B. Y., Chen, J.-J., Scully, R., Livingston, D. M., et al. (1999) · Nature Genetics · doi:10.1038/6029 · Cited by 414

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

Anderson, S. F., Schlegel, B. P., Nakajima, T., Wolpin, E. S., & Parvin, J. D. (1998) · Nature Genetics · doi:10.1038/930 · Cited by 393

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivationPreprint

Yu, V. P. C. C., Koehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., & Venkitaraman, A. R. (2000) · Genes & Development · doi:10.1101/gad.14.11.1400 · Cited by 321

Brca2 is required for embryonic cellular proliferation in the mouse.Preprint

Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A. C., Itié, A., et al. (1997) · Genes & Development · doi:10.1101/gad.11.10.1242 · Cited by 286

Direct DNA binding by Brca1

Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J., & Gellert, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111125998 · Cited by 282

Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

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The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

Baer, R. J. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00269-6 · Cited by 263

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

MacLachlan, T. K., Somasundaram, K., Sgagias, M. K., Shifman, Y., Muschel, R. J., Cowan, K. H., & El‐Deiry, W. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2777 · Cited by 211

Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control

Chen, C.-F., Chen, P.-L., Zhong, Q., Sharp, Z. D., & Lee, W.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32931 · Cited by 207

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., & Koller, B. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203334 · Cited by 197

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

Li, S., Chen, P., Subramanian, T., Chinnadurai, G., Tomlinson, G. E., Osborne, C. K., Sharp, Z. D., & Lee, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11334 · Cited by 192

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 190

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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p53 mutations in BRCA1-associated familial breast cancer

Crook, T., Crossland, S., Crompton, M. R., Osin, P., & Gusterson, B. A. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63327-2 · Cited by 179

Chromosomal Double-Strand Breaks Induce Gene Conversion at High Frequency in Mammalian Cells

Taghian, D. G., & Nickoloff, J. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6386 · Cited by 172

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

Thangaraju, M., Kaufmann, S. H., & Couch, F. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005824200 · Cited by 149

A Human BRCA2 Complex Containing a Structural DNA Binding Component Influences Cell Cycle Progression

Marmorstein, L. Y., Kinev, A. V., Chan, G. K. T., Bochar, D. A., Beniya, H., Epstein, J. A., Yen, T. J., & Shiekhattar, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00209-4 · Cited by 147

Coping with replication ‘train wrecks’ in Escherichia coli using Pol V, Pol II and RecA proteins

Goodman, M. F. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01564-4 · Cited by 107

The Expanding Role of Cell Cycle Regulators

Jacks, T., & Weinberg, R. A. (1998) · Science · doi:10.1126/science.280.5366.1035 · Cited by 103

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

Smith, P. D., Crossland, S., Parker, G. A., Osin, P., Brooks, L. A., Waller, J., Philp, E., Crompton, M. R., Gusterson, B. A., Allday, M. J., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202565 · Cited by 101

The Fuss about Mus81

Haber, J. E., & Heyer, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00593-1 · Cited by 97

Developmental Studies of Brca1 and Brca2 Knock-Out Mice

Hakem, R., de la Pompa, J. L., & Mak, T. W. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018792200700 · Cited by 91

Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain

Haile, D. T., & Parvin, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2113 · Cited by 83

A Derivative of an Ataxia-telangiectasia (A-T) Cell Line with Normal Radiosensitivity but A-T-like Inhibition of DNA Synthesis

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BRCA1 signals ARF-dependent stabilization and coactivation of p53

Somasundaram, K., MacLachlan, T. K., Burns, T. F., Sgagias, M. K., Cowan, K. H., Weber, B. L., & El‐Deiry, W. S. (1999) · Oncogene · doi:10.1038/sj.onc.1203284 · Cited by 66

BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription

Schlegel, B. P., Green, V. J., Ladias, J. A. A., & Parvin, J. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3148 · Cited by 63

BRCA2 Keeps Rad51 in Line

Powell, S. N., Willers, H., & Xia, F. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00789-x · Cited by 48

BRCA1 and BRCA2 - breast cancer susceptibility genes

Hofmann, W., & Schlag, P. M. (2000) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320000140 · Cited by 43

BRCA1 at a branch point

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The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase

Milner, J., Fuks, F., Hughes‐Davies, L., & Kouzarides, T. (2000) · Oncogene · doi:10.1038/sj.onc.1203793 · Cited by 25

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

Wu, X., Petrini, J. H. J., Heine, W. F., Weaver, D. T., Livingston, D. M., & Chen, J. (2000) · Science · doi:10.1126/science.289.5476.11 · Cited by 23

Involvement ofBRCA1 andBRCA2 in breast cancer in a western Finnish sub-population

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Hypoxia, DNA repair and genetic instability

Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140

Role of cell cycle in mediating sensitivity to radiotherapy

Pawlik, T. M., & Keyomarsi, K. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.03.005 · Cited by 1,155

Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613

Ionizing Radiation-Induced DNA Damage, Response, and Repair

Santivasi, W. L., & Xia, F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 637

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

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Therapeutic Exploitation of Tumor Cell Defects in Homologous Recombination

Powell, S. N., & Kachnic, L. A. (2008) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152008784220267 · Cited by 49

Abstract SY28-02: Connections in the BRCA1-BRCA2 pathway of homologous recombination: Implications for breast cancer development and treatment

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Breast cancer cells with deficiencies in BRCA1/BRCA2 show hypersensitivity to mitomycin C

Powell, S. N., Xia, F., Zhang, J., & Feng, Z. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)03146-2 · Cited by 3

Progress of BRCA1 in radiation induced breast carcinoma

Liu, W. (2006) · Zhonghua zhongliu fangzhi zazhi

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 363