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Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation
Abstract
Inheritance of one defective copy of either of the two breast cancer susceptibility genes, BRCA1 and BRCA2, predisposes individuals to breast and ovarian cancers. Current progress in determining the function of these genes suggests that they participate in a common pathway to facilitate orderly homologous recombination and thereby maintain genomic integrity. As a consequence of this defect in homologous recombination, tumors that arise in BRCA carriers are likely to be more sensitive to ionizing radiation. This review summarizes recent investigations about the nature of the defect in DNA repair, and highlights the unanswered questions about the tumor suppressor paradox of BRCA genes. The unsolved mystery is the other genetic changes that must occur to turn a BRCA-deficient cell from a nonviable cell into a tumor cell capable of endless growth.
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“Several studies suggest that BRCA gene mutation might influence response to radiation therapy because tumours in BRCA1/BRCA2 carriers are more sensitive to ionising radiation [5-12].”
From Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature (2010) · cites this paper as [11]
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Metadata
- Authors
- Powell, S. N., & Kachnic, L. A.
- Affiliations
- Massachusetts General Hospital (US)
- Boston Medical Center (US)
- Corresponding author
- Powell, Simon N
- Venue
- Oncogene
- Published
- 2003-08-28
- Volume
- 22
- Issue
- 37
- Pages
- 5784-5791
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2115808409
- Cited by
- 364
- References
- 65
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 29 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 23 · 2017: 17 · 2016: 19 · 2015: 12 · 2014: 12 · 2013: 20 · 2012: 14
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, BRCA2, homologous recombination, DNA replication fidelity, radiosensitivity, DNA repair, genome stability, breast cancer susceptibility, ovarian cancer susceptibility, tumor initiation
- MeSH terms
- DNA Replication, Humans, Neoplasms, Radiation, Ionizing, Recombination, Genetic, Apoptosis, Genes, BRCA1, Genes, BRCA2
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