Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819 · see citing works

Radiosensitivity in ataxia-telangiectasia: a new explanation.

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Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 772 · see citing works

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 758 · see citing works

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743 · see citing works

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

Socolovsky, M., Fallon, A. E. J., Wang, S., Brugnara, C., & Lodish, H. F. (1999) · Cell · doi:10.1016/s0092-8674(00)81013-2 · Cited by 695 · see citing works

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680 · see citing works

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635 · see citing works

Involvement of Brca2 in DNA Repair

Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 631 · see citing works

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626 · see citing works

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

Harkin, D. P., Bean, J. M., Miklos, D. B., Song, Y., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80769-2 · Cited by 558 · see citing works

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint

Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539 · see citing works

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

Somasundaram, K., Zhang, H., Zeng, Y., Houvras, Y. J., Peng, Y., Zhang, H., Wu, G. S., Licht, J. D., Weber, B. L., & El‐Deiry, W. S. (1997) · Nature · doi:10.1038/38291 · Cited by 509 · see citing works

BRCA1 is a component of the RNA polymerase II holoenzyme

Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., & Parvin, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5605 · Cited by 454 · see citing works

Evidence for a transcriptional activation function of BRCA1 C-terminal region

Monteiro, Á. N. A., August, A., & Hanafusa, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13595 · Cited by 447 · see citing works

Transcriptional activation by BRCA1

Chapman, M. S., & Verma, I. M. (1996) · Nature · doi:10.1038/382678a0 · Cited by 437 · see citing works

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Connor, F., Bertwistle, D., Mee, P. J., Ross, G. M., Swift, S., Grigorieva, E. F., Tybulewicz, V. L. J., & Ashworth, A. (1997) · Nature Genetics · doi:10.1038/ng1297-423 · Cited by 432 · see citing works

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389 · see citing works

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

Shen, S.-X., Ohler, Z. W., Xu, X., Li, C., Weinstein, M. B., Chen, L., Guan, X., Ried, T., & Deng, C. (1998) · Oncogene · doi:10.1038/sj.onc.1202243 · Cited by 329 · see citing works

Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

Tomlinson, G. E., Chen, T. T., Stastny, V., Virmani, A. K., Spillman, M. A., Tonk, V. S., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., et al. (1998) · PubMed · Cited by 292 · see citing works

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 genePreprint

Hua, X., Liu, X., Ansari, D. O., & Lodish, H. F. (1998) · Genes & Development · doi:10.1101/gad.12.19.3084 · Cited by 283 · see citing works

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

Hakem, R., de la Pompa, J. L., Elia, A., Potter, J., & Mak, T. W. (1997) · Nature Genetics · doi:10.1038/ng0797-298 · Cited by 252 · see citing works

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228 · see citing works

Location of BRCA1 in Human Breast and Ovarian Cancer Cells

Scully, R., Ganesan, S., Brown, M. A., Caprio, J. A. D., Cannistra, S. A., Feunteun, J., Schnitt, S. J., & Livingston, D. M. (1996) · Science · doi:10.1126/science.272.5258.123 · Cited by 217 · see citing works

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

Wilson, C., Payton, M. N., Elliott, G., Buaas, F. W., Cajulis, E. E., Grosshans, D. R., Ramos, L., Reese, D., Slamon, D. J., & Calzone, F. J. (1997) · Oncogene · doi:10.1038/sj.onc.1200924 · Cited by 193 · see citing works

Radiosensitivity in ataxia-telangiectasia

Cunliffe, P. N., Mann, J. R., Cameron, A., Roberts, K. D., & Ward, H. W. C. (1975) · British Journal of Radiology · doi:10.1259/0007-1285-48-569-374 · Cited by 189 · see citing works

Induction of apoptosis by the tumor suppressor protein BRCA1.

Shao, N., Chai, Y. L., Shyam, E., Reddy, P., & Rao, V. N. (1996) · PubMed · Cited by 137 · see citing works

Induction and Rejoining of DNA Double-Strand Breaks and Interphase Chromosome Breaks after Exposure to X Rays in One Normal and Two Hypersensitive Human Fibroblast Cell Lines

Badie, C., Iliakis, G. E., Foray, N., Alsbeih, G., Cedervall, B., Chavaudra, N., Pantelias, G. E., Arlett, C. F., & Malaise, E. P. (1995) · Radiation Research · doi:10.2307/3579232 · Cited by 104 · see citing works

The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors

Socolovsky, M., Dusanter‐Fourt, I., & Lodish, H. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14009 · Cited by 93 · see citing works

Mammary tumor formation in p53- and BRCA1-deficient mice.

Cressman, V. L., Backlund, D. C., Hicks, E., Gowen, L. C., Godfrey, V., & Koller, B. H. (1999) · PubMed · Cited by 84 · see citing works

Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look

Foray, N., Arlett, C. F., & Malaise, E. P. (1997) · Biochimie · doi:10.1016/s0300-9084(97)82005-6 · Cited by 68 · see citing works

SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells

Kiltie, A. E. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2945 · Cited by 53 · see citing works

Structural changes in chromatin as the basis for radiosensitivity in ataxia telangiectasia

Painter, R. B. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000131738 · Cited by 39 · see citing works

Relationship between a chromatin anomaly in ataxia-telangiectasia cells and enhanced sensitivity to DNA damage

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Induction and Repair of DNA Double-Strand Breaks

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Update on breast cancer susceptibility genes.

Weber, B. (1998) · Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · doi:10.1007/978-3-642-45769-2_5 · Cited by 27 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

DNA double-strand break repair-pathway choice in somatic mammalian cells

Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,445 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198 · see citing works

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., & Nakatani, Y. (2000) · Cell · doi:10.1016/s0092-8674(00)00051-9 · Cited by 1,029 · see citing works

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

Silver, D. P., Richardson, A. L., Eklund, A. C., Wang, Z. C., Szállási, Z., Li, Q., Birkbak, N. J., Leong, C.-O., Calogrias, D., Buraimoh, A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4725 · Cited by 982 · see citing works

BRCA1 and BRCA2: 1994 and beyond

Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967 · see citing works

Relevance of Breast Cancer Cell Lines as Models for Breast Tumours: An Update

Lacroix, M., & Leclercq, G. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000014042.54925.cc · Cited by 784 · see citing works

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

Yoshida, K., & Miki, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02195.x · Cited by 753 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

Deng, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl010 · Cited by 583 · see citing works

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Bhattacharyya, A., Ear, U., Koller, B. H., Weichselbaum, R. R., & Bishop, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000276200 · Cited by 584 · see citing works

Regulation and mechanisms of mammalian double-strand break repair

Valerie, K. C., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 572 · see citing works

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 556 · see citing works

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546 · see citing works

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545 · see citing works

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512 · see citing works

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483 · see citing works

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Wu, X., Ranganathan, V., Weisman, D., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G. A., et al. (2000) · Nature · doi:10.1038/35013089 · Cited by 446 · see citing works

Homologous recombinational repair of DNA ensures mammalian chromosome stability

Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 426 · see citing works

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

Moskwa, P., Buffa, F. M., Pan, Y., Panchakshari, R. A., Gottipati, P., Muschel, R. J., Beech, J. S., Kulshrestha, R., Abdelmohsen, K., Weinstock, D. M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.005 · Cited by 428 · see citing works

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429 · see citing works

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

Chen, L., Nievera, C. J., Lee, A. Y., & Wu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710245200 · Cited by 425 · see citing works

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382 · see citing works

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

Powell, S. N., & Kachnic, L. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206678 · Cited by 364 · see citing works

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 356 · see citing works

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

Ruffner, H., Joazeiro, C. A. P., Hemmati, D., Hunter, T., & Verma, I. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081068398 · Cited by 359 · see citing works

BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization

Ventii, K., Devi, N. S., Friedrich, K. L., Chernova, T. A., Tighiouart, M., Meir, E. G. V., & Wilkinson, K. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0365 · Cited by 337 · see citing works

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

Zhang, J., Willers, H., Feng, Z., Ghosh, J. C., Kim, S., Weaver, D. T., Chung, J. H., Powell, S. N., & Xia, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.708-718.2004 · Cited by 323 · see citing works

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang, S., Weiler, S. R., Ganesan, S., Chaudhuri, J., Zhu, C., Artandi, S. E., Rudolph, K. L., Gottlieb, G. J., Chin, L., et al. (2000) · Nature Genetics · doi:10.1038/79232 · Cited by 309 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

Ganesan, S., Silver, D. P., Greenberg, R. A., Avni, D., Drapkin, R., Miron, A., Mok, S. C., Randrianarison-Huetz, V., Brodie, S. G., Salstrom, J. L., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01052-8 · Cited by 301 · see citing works

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.

Williams, R. S., Green, R., & Glover, J. N. M. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-838 · Cited by 292 · see citing works

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Gorrini, C., Baniasadi, P. S., Harris, I. S., Silvester, J., Inoue, S., Snow, B., Joshi, P. A., Wakeham, A., Molyneux, S. D., Martin, B., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121337 · Cited by 289 · see citing works

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

Dong, Y., Hakimi, M., Chen, X., Kumaraswamy, E., Cooch, N. S., Godwin, A. K., & Shiekhattar, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00424-6 · Cited by 274 · see citing works

Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients

Byrski, T., Huzarski, T., Dent, R. A., Marczyk, E., Jasiówka, M., Gronwald, J., Jakubowicz, J., Cybulski, C., Wiśniowski, R., Godlewski, D. D., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3100-x · Cited by 269 · see citing works

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263 · see citing works

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Clapperton, J. A., Manke, I. A., Lowery, D. M., Ho, T., Haire, L. F., Yaffe, M. B., & Smerdon, S. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb775 · Cited by 243 · see citing works

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240 · see citing works

Functions of BRCA1 and BRCA2 in the biological response to DNA damage

Venkitaraman, A. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3591 · Cited by 232 · see citing works

The role of BRCA1 in DNA damage response

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Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair

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RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1 -Deficient Breast Tumors

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Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

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The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response

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Analysis ofBRCA1andBRCA2genes in Spanish breast/ovarian cancer patients: A high proportion of mutations unique to Spain and evidence of founder effects

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BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

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BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

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Mechanisms of BRCA1 Tumor Suppression

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BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II

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MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaksPreprint

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BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks

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BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

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CCDC98 targets BRCA1 to DNA damage sites

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BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

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A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

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Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

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Detection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations

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Functional Characterization of a Novel BRCA1-Null Ovarian Cancer Cell Line in Response to Ionizing Radiation

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Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

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Chromosomal breakage syndromes and the BRCA1 genome surveillance complex

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Analysis of the DNA Substrate Specificity of the Human BACH1 HelicaseAssociated with BreastCancer

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A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

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MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

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Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study

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Identification of genes induced by BRCA1 in breast cancer cells

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Functional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants

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BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

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Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

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BRCA1 interacts directly with the Fanconi anemia protein FANCA

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BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

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Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

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New complexities for BRCA1 and BRCA2

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Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

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Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

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BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

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Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

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BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis

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Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

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Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks

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Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression

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BRCA1 Promotes Induction of ssDNA by Ionizing Radiation

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211 BRCA1 functions as a differential modulator of chemotherapy induced apoptosis

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Progress in role of breast cancer susceptibility gene 1 in DNA damage repair

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BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

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BRCA1 Promotes Induction of ssDNA by Ionizing Radiation

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The Role of BRCA1 in DNA Double-strand Break Repair

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