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Liver stem cells and hepatocellular carcinoma†

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

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Blocking CDK1/PDK1/β-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma

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Hair follicle stem cells: Walking the maze

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Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

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microRNAs regulate human embryonic stem cell division

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Cancer Stem Cells as Mediators of Treatment Resistance in Brain Tumors: Status and Controversies

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DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis

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Runx1 Directly Promotes Proliferation of Hair Follicle Stem Cells and Epithelial Tumor Formation in Mouse Skin

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miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding

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Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine

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Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3

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Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

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Sox2 Suppression by miR-21 Governs Human Mesenchymal Stem Cell Properties

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Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells

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Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.

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A critical role for Apc in hematopoietic stem and progenitor cell survival

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The MicroRNA Pathway Plays a Regulatory Role in Stem Cell Division

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Cell cycle regulation of hematopoietic stem or progenitor cells

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Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin

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Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model

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Nanotechnology in oncology: advances in biosynthesis, drug delivery, and theranostics

Ammar, M. M., Ali, R., Elaziz, N. A. A., Habib, H., Abbas, F. M., Yassin, M. T., Maniah, K., & Abdelaziz, R. (2025) · Discover Oncology · doi:10.1007/s12672-025-02664-3 · Cited by 64

Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms

Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.018 · Cited by 68

Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a

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Evolving Therapies and FAK Inhibitors for the Treatment of Cancer

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p27Kip1 Constrains Proliferation of Neural Progenitor Cells in Adult Brain Under Homeostatic and Ischemic Conditions

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The Antiangiogenic Factor, 16-kDa Human Prolactin, Induces Endothelial Cell Cycle Arrest by Acting at Both the G0–G1 and the G2–M Phases

Tabruyn, S. P., Nguyen, N.-Q.-N., Cornet, A. M., MARTIAL, J. A., & Struman, I. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0515 · Cited by 52

Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells

Gao, Y., Yang, P., Shen, H., Yu, H. M., Song, X., Zhang, L., Zhang, P., Cheng, H., Xie, Z., Hao, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7328 · Cited by 49

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodríguez, S., Wang, L., Mumaw, C. L., Srour, E. F., Celso, C. L., Nakayama, K. I., & Carlesso, N. (2011) · Blood · doi:10.1182/blood-2010-11-321521 · Cited by 48

Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle

Su, L. (2009) · Oncology Reports · doi:10.3892/or_00000599 · Cited by 46

Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3

Wang, Y., Gao, A., Zhao, H., Lu, P., Cheng, H., Dong, F., Gong, Y., Ma, S., Zheng, Y., Zhang, H., et al. (2016) · Leukemia · doi:10.1038/leu.2016.81 · Cited by 39

Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells

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Survivin (BIRC5) cell cycle computational network in human no‐tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation

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Transmission distortion by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation

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Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy

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DDAH1 Deficiency Attenuates Endothelial Cell Cycle Progression and Angiogenesis

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Methanol extract of the seaweed Gloiopeltis furcata induces G2/M arrest and inhibits cyclooxygenase‐2 activity in human hepatocarcinoma HepG2 cells

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Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow

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DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

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Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis

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A novel approach to the identification and enrichment of cancer stem cells from a cultured human glioma cell line

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Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment

Tian, C., Zheng, G., Cao, Z., Li, Q., Ju, Z., Wang, J., Yuan, W., & Cheng, T. (2013) · Cell Cycle · doi:10.4161/cc.23160 · Cited by 30

Expansion of hematopoietic stem/progenitor cells

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The CDK inhibitors: potential targets for therapeutic stem cell manipulations?

Boyer, M. J., & Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303064 · Cited by 34

Molecular and Cellular Basis of Regeneration and Tissue Repair

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Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis

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Toward ‘SMART’ stem cells

Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303066 · Cited by 26

miR-26a Mediates Adipogenesis of Amniotic Fluid Mesenchymal Stem/Stromal Cells via PTEN, Cyclin E1, and CDK6

Trohatou, O., Zagoura, D., Orfanos, N. K., Pappa, K. I., Marinos, E., Anagnou, N. P., & Roubelakis, M. G. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0203 · Cited by 25

Cyclin E and CDK2 Repress the Terminal Differentiation of Quiescent Cells after Asymmetric Division in C. elegans

Fujita, M., Takeshita, H., & Sawa, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000407 · Cited by 25

Aberrant methylation and reduced expression of RASSF1A in Ewing sarcoma

Avigad, S., Shukla, S., Naumov, I., Cohen, I. J., Ash, S., Meller, I., Kollender, Y., Issakov, J., & Yaniv, I. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22115 · Cited by 25

Novel Triazole-Piperazine Hybrid Molecules Induce Apoptosis via Activation of the Mitochondrial Pathway and Exhibit Antitumor Efficacy in Osteosarcoma Xenograft Nude Mice Model

Mishra, C. B., Mongre, R. K., Kumari, S., Jeong, D. K., & Tiwari, M. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01007 · Cited by 24

Implications of a simple mathematical model to cancer cell population dynamics

Garner, A. L., Lau, Y. Y., Jordan, D. W., Uhler, M. D., & Gilgenbach, R. M. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00368.x · Cited by 24

Cancerous stem cells: deviant stem cells with cancer-causing misbehavior

Chandler, J. M., & Lagasse, E. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt13 · Cited by 25

Hematopoietic Stem Cells Are Not the Direct Target of Spontaneous Leukemic Transformation in p18INK4C-Null Reconstituted Mice

Yuan, Y., Yu, H. M., Boyer, M. J., Song, X., Cao, S., Shen, H., & Cheng, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2945 · Cited by 22

Regulating Quiescence: New Insights into Hematopoietic Stem Cell Biology

Passegue, E. A., & Wagers, A. J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.002 · Cited by 21

Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Li, B., Jia, N., Waning, D. L., Yang, F., Haneline, L. S., & Chun, K. T. (2007) · Blood · doi:10.1182/blood-2006-12-064154 · Cited by 20

Pleiotropic p27Kip1, BCR-ABL and leukemic stem cell: the trio in concert

Sengupta, A., & Banerjee, S. (2007) · Leukemia · doi:10.1038/sj.leu.2404842 · Cited by 20

A molecular signaling map and its application

Li, J., & Mansmann, U. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.022 · Cited by 19

Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells

Chen, F., Liu, X., Chen, Y., Liu, J. Y., Lü, H., Wang, W., Lu, X., Dean, K. C., Gao, L., Kaplan, H. J., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.102618 · Cited by 19

Identification of Proteomic Changes during Differentiation of Adult Mouse Subventricular Zone Progenitor Cells

Salim, K., Guest, P. C., Skynner, H. A., Bilsland, J., Bonnert, T. P., McAllister, G., & Muñoz-Sanjuán, I. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.00100 · Cited by 19

Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms

Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.026 · Cited by 18

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Glasstetter, L. M., Oderinde, T. S., Mirchandani, M., Rajagopalan, K. S., Barsom, S. H., Thaler, R., Siddiqi, S., Zhu, X., Tang, H. R., Jordan, K. L., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03372-x · Cited by 17

Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis

Yousef, H., Conboy, M. J., Mamiya, H., Zeiderman, M., Schlesinger, C., Schaffer, D. V., & Conboy, I. M. (2014) · Aging · doi:10.18632/aging.100659 · Cited by 16

Early hematopoiesis inhibition under chronic radiation exposure in humans

Akleyev, А. V., Akushevich, I. V., Dimov, G. P., Veremeyeva, G. A., Varfolomeyeva, T. A., Ukraintseva, S. V., & YASHIN, A. I. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0269-1 · Cited by 16

Long non‐coding RNA MRPL23‐AS1 suppresses anoikis in salivary adenoid cystic carcinoma in vitro

Li, Y., Fu, M., Song, Y., Li, H., & Ge, X. (2022) · Oral Diseases · doi:10.1111/odi.14156 · Cited by 15

Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors

Tomiatti, V., Istvánffy, R., Pietschmann, E., Kratzat, S., Hoellein, A., Quintanilla-Fend, L., von Bubnoff, N. C. C., Peschel, C., Oostendorp, R. A. J., & Keller, U. B. (2014) · Oncogene · doi:10.1038/onc.2014.364 · Cited by 15

Cancer stem cells and brain tumors: uprooting the bad seeds

Lee, D. Y., & Gutmann, D. H. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.11.1581 · Cited by 15

Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging

Ju, Z., Zhang, J., Gao, Y., & Cheng, T. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0882-z · Cited by 14

An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells

Li, Y., Pal, R., Sung, L., Feng, H., Miao, W., Cheng, S., Tian, C., & Cheng, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045212 · Cited by 12

p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor

Han, X., Kuang, Y., Chen, H., Liu, T., Zhang, J., & Liu, J. (2019) · Current Drug Targets · doi:10.2174/1389450120666190809161901 · Cited by 11

Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression

Biferi, M. G., Nicoletti, C., Falcone, G., Puggioni, E. M. R., Passaro, N., Mazzola, A., Pajalunga, D., Zaccagnini, G., Rizzuto, E., Auricchio, A., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.27 · Cited by 11

The impact of tumor microenvironments on stem cells

Wang, L., Cheng, T., & Zheng, G. (2013) · Translational Cancer Research · doi:10.21037/1675 · Cited by 8

Expression of P16 cell cycle inhibitor in human cord blood CD34+ expanded cells following co-culture with bone marrow-derived mesenchymal stem cells

Oodi, A., Noruzinia, M., Roudkenar, M. H., Nikougoftar, M., Soltanpour, M. S., Khorshidfar, M., & Amirizadeh, N. (2012) · Hematology · doi:10.1179/1607845412y.0000000009 · Cited by 8

Assessing the prognostic value of stemness-related genes in breast cancer patients

Wang, W., Wang, H., Wang, M.-S., Huang, Y., Ma, Y.-Y., Qi, J., Shi, J., & Li, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-73164-3 · Cited by 6

Preleukemic stem cells: leave it or not?

Su, M., Cheng, H., & Cheng, T. (2020) · Blood Science · doi:10.1097/bs9.0000000000000042 · Cited by 6

Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?

Wang, S., Liu, Y., Yu, S., Bai, J., & Hao, C. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00441-0 · Cited by 6

p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells

Wang, N., Yang, S., Li, Y., Gou, F., Lv, Y., Zhao, X., Wang, Y., Xu, C., Zhou, B., Dong, F., et al. (2024) · Protein & Cell · doi:10.1093/procel/pwae022 · Cited by 5

Effects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells

Zawada, W. M., & Das, M. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195183139.003.0012 · Cited by 5

Expression and promoter methylation changes of the P15INK4bduringex vivocord blood CD34+cell expansion following co-culture with mesenchymal stromal cells

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Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential

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