Cited by 119Cancer Cells and MetastasisCancer-related Molecular PathwaysHematopoietic Stem Cell Transplantation

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Cell cycle inhibitors in normal and tumor stem cells.

Cheng, Tao·2004·Oncogene

DOI 10.1038/sj.onc.1207945

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Abstract

Emerging data suggest that stem cells may be one of the key elements in normal tissue regeneration and cancer development, although they are not necessarily the same entity in both scenarios. As extensively demonstrated in the hematopoietic system, stem cell repopulation is hierarchically organized and is intrinsically limited by the intracellular cell cycle inhibitors. Their inhibitory effects appear to be highly associated with the differentiation stage in stem/progenitor pools. While this negative regulation is important for maintaining homeostasis, especially at the stem cell level under physiological cues or pathological insults, it constrains the therapeutic use of adult stem cells in vitro and restricts endogenous tissue repair after injury. On the other hand, disruption of cell cycle inhibition may contribute to the formation of the so-called 'tumor stem cells' (TSCs) that are currently hypothesized to be partially responsible for tumorigenesis and recurrence of cancer after conventional therapies. Therefore, understanding how cell cycle inhibitors control stem cells may offer new strategies not only for therapeutic manipulations of normal stem cells but also for novel therapies selectively targeting TSCs.

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Fortunel NO, Hatzfeld A and Hatzfeld JA . (2000). Blood, 96, 2022–2036. · DOI
Yaroslavskiy B, Watkins S, Donnenberg AD, Patton TJ and Steinman RA . (1999). Blood, 93, 2907–2917. · DOI

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Authors: Cheng, T.
Affiliations: University of Pittsburgh (US)
Corresponding author: Cheng, Tao
ORCID: Cheng, Tao
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2004-09-20
Volume: 23
Issue: 43
Pages: 7256-7266
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1207945
OpenAlex: W1991227964
Cited by: 117
References: 128
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 14 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 4
FWCI: 0.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: American Society of Hematology
National Institutes of Health
National Heart, Lung, and Blood Institute (HL70561, R01HL070561)
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK002761, DK 02761)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: cell cycle inhibitors, stem cells, cancer stem cells, hematopoietic stem cells, stem cell differentiation, tissue regeneration, tumor recurrence, carcinogenesis, adult stem cell therapy, tissue homeostasis
MeSH terms: Animals, Cell Cycle, Cell Division, Humans, Neoplasm Proteins, Saccharomyces cerevisiae, Stem Cells, Neoplastic Stem Cells, Cyclins, Mice, Knockout, Cell Cycle Proteins, Cyclin-Dependent Kinases, Mice

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Cell cycle inhibitors in normal and tumor stem cells.

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