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Cited by 119Cancer Cells and MetastasisCancer-related Molecular PathwaysHematopoietic Stem Cell Transplantation

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Cell cycle inhibitors in normal and tumor stem cells.

Cheng, Tao·2004·Oncogene
DOI 10.1038/sj.onc.1207945
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Abstract

Emerging data suggest that stem cells may be one of the key elements in normal tissue regeneration and cancer development, although they are not necessarily the same entity in both scenarios. As extensively demonstrated in the hematopoietic system, stem cell repopulation is hierarchically organized and is intrinsically limited by the intracellular cell cycle inhibitors. Their inhibitory effects appear to be highly associated with the differentiation stage in stem/progenitor pools. While this negative regulation is important for maintaining homeostasis, especially at the stem cell level under physiological cues or pathological insults, it constrains the therapeutic use of adult stem cells in vitro and restricts endogenous tissue repair after injury. On the other hand, disruption of cell cycle inhibition may contribute to the formation of the so-called 'tumor stem cells' (TSCs) that are currently hypothesized to be partially responsible for tumorigenesis and recurrence of cancer after conventional therapies. Therefore, understanding how cell cycle inhibitors control stem cells may offer new strategies not only for therapeutic manipulations of normal stem cells but also for novel therapies selectively targeting TSCs.

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Crossref · 10.1038/sj.onc.1207945

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Research works printed but not linked: 2

  1. Fortunel NO, Hatzfeld A and Hatzfeld JA . (2000). Blood, 96, 2022–2036. · DOI
  2. Yaroslavskiy B, Watkins S, Donnenberg AD, Patton TJ and Steinman RA . (1999). Blood, 93, 2907–2917. · DOI

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Metadata

Authors
Cheng, T.
Affiliations
University of Pittsburgh (US)
Corresponding author
Cheng, Tao
ORCID
Cheng, Tao
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2004-09-20
Volume
23
Issue
43
Pages
7256-7266
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
DOI
10.1038/sj.onc.1207945
OpenAlex
W1991227964
Cited by
117
References
128
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 14 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 4
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Society of Hematology
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL70561, R01HL070561)
  • National Institute of Diabetes and Digestive and Kidney Diseases (K08DK002761, DK 02761)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
cell cycle inhibitors, stem cells, cancer stem cells, hematopoietic stem cells, stem cell differentiation, tissue regeneration, tumor recurrence, carcinogenesis, adult stem cell therapy, tissue homeostasis
MeSH terms
Animals, Cell Cycle, Cell Division, Humans, Neoplasm Proteins, Saccharomyces cerevisiae, Stem Cells, Neoplastic Stem Cells, Cyclins, Mice, Knockout, Cell Cycle Proteins, Cyclin-Dependent Kinases, Mice

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