Cited by 357Metabolism, Diabetes, and CancerCancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation

Buzzai, Monica, Bauer, Daniel E, Jones, Russell G, DeBerardinis, Ralph J, Hatzivassiliou, Georgia, Elstrom, Rebecca L, Thompson, Craig B·2005·Oncogene

DOI 10.1038/sj.onc.1208622

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Abstract

Activation of the oncogenic kinase Akt stimulates glucose uptake and metabolism in cancer cells and renders these cells susceptible to death in response to glucose withdrawal. Here we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reverses the sensitivity of Akt-expressing glioblastoma cells to glucose deprivation. AICAR's protection depends on the activation of AMPK, as expression of a dominant-negative form of AMPK abolished this effect. AMPK is a cellular energy sensor whose activation can both block anabolic pathways such as protein synthesis and activate catabolic reactions such as fatty acid oxidation to maintain cellular bioenergetics. While rapamycin treatment mimicked the effect of AICAR on inhibiting markers of cap-dependent translation, it failed to protect Akt-expressing cells from death upon glucose withdrawal. Compared to control cells, Akt-expressing cells were impaired in the ability to induce fatty acid oxidation in response to glucose deprivation unless stimulated with AICAR. Stimulation of fatty acid oxidation was sufficient to maintain cell survival as activation of fatty acid oxidation with bezafibrate also protected Akt-expressing cells from glucose withdrawal-induced death. Conversely, treatment with a CPT-1 inhibitor to block fatty acid import into mitochondria prevented AICAR from stimulating fatty acid oxidation and promoting cell survival in the absence of glucose. Finally, cell survival did not require reversal of Akt's effects on either protein translation or lipid synthesis as the addition of the cell penetrant oxidizable substrate methyl-pyruvate was sufficient to maintain survival of Akt-expressing cells deprived of glucose. Together, these data suggest that activation of Akt blocks the ability of cancer cells to metabolize nonglycolytic bioenergetic substrates, leading to glucose addiction.

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454
Self-citation
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232
Oncogenic alterations of metabolism
Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,048
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., & Hay, N. (2001) · Genes & Development · doi:10.1101/gad.889901 · Cited by 961

Show all 29 references

Research works printed but not linked: 1

Corton JM, Gillespie JG, Hawley SA and Hardie DG . (1995). Eur. J. Biochem., 229, 558–565. · DOI

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Authors: Buzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B.
Affiliations: Abramson Cancer Center (US)
Children's Hospital of Philadelphia (US)
Corresponding author: Thompson, Craig B
ORCID: Bauer, Daniel E
Jones, Russell G
DeBerardinis, Ralph J
Hatzivassiliou, Georgia
Thompson, Craig B
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2005-04-04
Volume: 24
Issue: 26
Pages: 4165-4173
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1208622
OpenAlex: W1964353872
Cited by: 357
References: 29
Citations by year: 2025: 8 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 27 · 2018: 16 · 2017: 17 · 2016: 19 · 2015: 15 · 2014: 35 · 2013: 23 · 2012: 34
FWCI: 5.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: Damon Runyon Cancer Research Foundation
University of Pennsylvania
National Institutes of Health
National Institute of General Medical Sciences (5T32-GM008638-08, T32GM008638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: Akt, glucose deprivation, fatty acid beta-oxidation, AMPK, AICAR, glioblastoma, rapamycin, cap-dependent translation, bezafibrate, methyl pyruvate, cancer metabolism, energy sensing, cell survival
MeSH terms: Aminoimidazole Carboxamide, Cell Survival, Fatty Acids, Glioma, Glucose, Humans, Hypoglycemic Agents, Oxidation-Reduction, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Ribonucleotides, Tumor Cells, Cultured, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt

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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation

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