Hematopoietic cytokine receptor signaling
Abstract
Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of these diverse pathways forms the basis for an orderly generation of different cell types. Recent studies conducted over the past 10-15 years have revealed that hematopoietic cytokine receptor signaling is largely mediated by a family of tyrosine kinases termed Janus kinases (JAKs) and their downstream transcription factors termed STATs (signal transducers and activators of transcription). Aberration in these pathways, such as that caused by the recently identified JAK2V617F mutation, is an underlying cause for diseases such as leukemias and other myeloproliferative disorders. This recent discovery, when coupled with the fact that STATs are activated by oncoproteins such as BCR-ABL, underscores the importance of the JAK-STAT pathway in both normal cellular development and disease states.
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Many cytokines bind receptors composed of heterologous polypeptide chains, several of which are shared; a single or combination of two to three JAKs selectively associates with each receptor, and a combination of different STATs can be activated by a single cytokine.
“Many cytokines bind to receptors composed of heterologous polypeptide chains, and several of the polypeptide chains are common or shared. In addition, a single or combination of two to three JAKs selectively associates with each receptor (Lin et al., 1995; Baker et al., 2007; Kiu and Nicholson, 2012) (Fig. 2). The consequence is that a combination of different STATs can be activated by a single cy”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Baker et al., 2007
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“In addition, a single or combination of two to three JAKs selectively associates with each receptor (Lin et al., 1995; Baker et al., 2007; Kiu and Nicholson, 2012) (Fig.”
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- Authors
- Baker, S. J., Rane, S. G., & Reddy, E. P.
- Affiliations
- Temple University (US)
- National Institutes of Health (US)
- Corresponding author
- Reddy, E P
- ORCID
- Venue
- Oncogene
- Published
- 2007-10-15
- Volume
- 26
- Issue
- 47
- Pages
- 6724-6737
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2084178693
- Cited by
- 256
- References
- 2
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 13 · 2020: 15 · 2019: 6 · 2018: 17 · 2017: 14 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 28
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL080666)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Genetics › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Keywords
- JAK/STAT signaling, Janus kinase, STAT transcription factors, JAK2 V617F mutation, myeloproliferative neoplasms, leukemia, BCR-ABL, hematopoiesis, tyrosine kinase
- MeSH terms
- Animals, Hematopoiesis, Hematopoietic Stem Cells, Humans, Signal Transduction, Cytokines, Receptors, Cytokine
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