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Hematopoietic cytokine receptor signaling

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JAKs, STATs and Src kinases in hematopoiesis

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Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

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Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

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JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders: Approaches for Targeted Therapies

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Leukemia Inhibitory Factor–dependent Transcriptional Activation in Embryonic Stem Cells

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The role of STATs in myeloid differentiation and leukemia

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Serine Phosphorylation and Negative Regulation of Stat3 by JNK

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Signaling network of the Btk family kinases

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STAT3 in the Systemic Inflammation of Cancer Cachexia

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IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

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GRIM‐19, a death‐regulatory gene product, suppresses Stat3 activity via functional interaction

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The c‐myc Promoter: Still MysterY and Challenge

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Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling

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Protein Kinase C δ Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner*

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Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

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The STAT3 pathway as a therapeutic target in head and neck cancer: barriers and innovations

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Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells

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STAT3 the oncogene – still eluding therapy?

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Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

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STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

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Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult

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STAT proteins as novel targets for cancer therapy

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Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck

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Activation of STAT3 by the Src Family Kinase Hck Requires a Functional SH3 Domain

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The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells

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Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein

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Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

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Signal Transducers and Activators of Transcription (STATs): Novel Targets of Chemopreventive and Chemotherapeutic Drugs

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Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)

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Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

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Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration

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Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer

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The function of Stat3 in tumor cells and their microenvironment.

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Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms

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Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a

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The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

Zhang, T., Kee, W. H., Seow, K. T., Fung, W., & Cao, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7132-7139.2000 · Cited by 150 · see citing works

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

Karras, J., Wang, Z.-H., Huo, L., Howard, R., Frank, D., & Rothstein, T. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.185.6.1035 · Cited by 160 · see citing works

STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5

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Reactive Oxygen Species as Mediators of Signal Transduction in Ischemic Preconditioning

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Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation

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STAT5-Dependent CyclinD1 and Bcl-xL Expression in Bcr-Abl-Transformed Cells

de Groot, R. P., Raaijmakers, J. A. M., Lammers, J. J., & Koenderman, L. (2000) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.2000.0231 · Cited by 140 · see citing works

Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene

Hermans, M. H. A., Antonissen, C., Ward, A. C., Mayen, A. E. M., Ploemacher, R., & Touw, I. P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.683 · Cited by 139 · see citing works

Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

Liu, H., Ma, Y., Cole, S. M., Zander, C., Chen, K.-H., Karras, J., & Pope, R. M. (2003) · Blood · doi:10.1182/blood-2002-11-3396 · Cited by 136 · see citing works

VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma

Chen, H., Ye, D.-F., Xie, X., Chen, B., & Lü, W. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.05.056 · Cited by 134 · see citing works

Control of myeloid differentiation and survival by Stats

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G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation

Ram, P. T., & Iyengar, R. (2001) · Oncogene · doi:10.1038/sj.onc.1204186 · Cited by 131 · see citing works

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

Eiring, A. M., Page, B. D. G., Kraft, I. L., Mason, C. C., Vellore, N. A., Resetca, D., Zabriskie, M. S., Zhang, T. Y., Khorashad, J. S., Engar, A., et al. (2014) · Leukemia · doi:10.1038/leu.2014.245 · Cited by 132 · see citing works

Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia

Ward, A. C., van Aesch, Y. M., Schelen, A. M., & Touw, I. P. (1999) · Blood · doi:10.1182/blood.v93.2.447 · Cited by 131 · see citing works

STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation

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An essential role for SRC-activated STAT-3 in 14,15-EET–induced VEGF expression and angiogenesis

Cheranov, S. Y., Karpurapu, M., Wang, D., Zhang, B., Venema, R. C., & Rao, G. N. (2008) · Blood · doi:10.1182/blood-2007-11-126680 · Cited by 127 · see citing works

PI3K and STAT3: A New Alliance

Vogt, P. K., & Hart, J. R. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0218 · Cited by 128 · see citing works

Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation

Xia, L., Wang, L., Chung, A. S., Ivanov, S. S., Ling, M. Y., Dragoi, A. M., Platt, A., Gilmer, T. M., Fu, X.-Y., & Chin, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202823200 · Cited by 126 · see citing works

A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation

Besser, D., Bromberg, J., Darnell, J. E., Jr., & Hanafusa, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1401 · Cited by 123 · see citing works

Regulation of Stat3 nuclear import by importin α5 and importin α7 via two different functional sequence elements

Ma, J., & Cao, X. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.06.016 · Cited by 119 · see citing works

STAT Signaling in the Pathogenesis and Treatment of Cancer

Frank, D. A. (1999) · Molecular Medicine · doi:10.1007/bf03403538 · Cited by 116 · see citing works

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

Zhang, Y., Turkson, J., Carter‐Su, C., Smithgall, T. E., Levitzki, A., Kraker, A. J., Krolewski, J. J., Medveczky, P. G., & Jove, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002383200 · Cited by 164 · see citing works

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

Cirri, P., Chiarugi, P., Marra, F., Raugei, G., Camici, G., Manao, G., & Ramponi, G. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7493 · Cited by 67 · see citing works

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

Wang, Y.-Z., Wharton, W., Garcia, R., Kraker, A. J., Jove, R., & Pledger, W. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203548 · Cited by 111 · see citing works

Constitutive Activation of JAK1 in Src-transformed Cells

Campbell, G. S., Yu, C., Jove, R., & Carter‐Su, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2591 · Cited by 85 · see citing works

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ

Garcia, R., Yu, C.-L., Hudnall, A., Catlett, R., Nelson, K. L., Smithgall, T., Fujita, D. J., Ethier, S. P., & Jove, R. (1997)