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Cited by 308Iron Metabolism and DisordersNeutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

The effect of iron deficiency anemia on the function of the immune system.

Ekiz, Ceyda, Agaoglu, Leyla, Karakas, Zeynep, Gurel, Nuray, Yalcin, Işık·2005·The Hematology Journal
DOI 10.1038/sj.thj.6200574
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Abstract

We aimed to study the effect of iron deficiency anemia (IDA) on immunity. In 32 children with IDA and 29 normal children, the percentage of T-lymphocyte subgroups, the level of serum interleukin-6 (IL-6); and the phagocytic activity, the oxidative burst activity of neutrophils and monocytes and the levels of immunoglobulins were compared. There was no difference in the distribution of T-lymphocyte subgroups. The mean IL-6 levels was 5.6+/-3.9 pg/ml in children with IDA and 10.3+/-5.3 pg/ml in the control group (P<0.001). The percentage of neutrophils with oxidative burst activity when stimulated with pma was 53.4+/-32.7% in children with IDA and 81.7+/-14.3% in the control group (P=0.005). The percentage of monocytes with oxidative burst activity was 13.8+/-11.7% in children with IDA and 35+/-20.0% in the control group (P<0.001) when stimulated with pma. and 4.3+/-3.1 versus 9.7+/-6.0% (P=0.008) when stimulated with fMLP. The ratio of neutrophils with phagocytic activity was 58.6+/-23.3% in the anemic group; and 74.2+/-17.7% in the control group (P=0.057). The ratio of monocytes with phagocytic activity was 24.3+/-12.0% in the anemic group; and 42.9+/-13.4% in the control group (P=0.001). IgG4 level was 16.7+/-16.6 mg/dl in children with IDA and 51.8+/-40.7 mg/dl in healthy children (P<0.05). These results suggest that humoral, cell-mediated and nonspecific immunity and the activity of cytokines which have an important role in various steps of immunogenic mechanisms are influ…

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  • Reduced RBC levels impair oxygen transport, leading to diminished physical capabilities, impaired feeding behaviors, increased organ damage, and compromised immune systems.

    “Reduced RBC levels impair oxygen transport, leading to diminished physical capabilities, impaired feeding behaviors, increased organ damage, and compromised immune systems (Canny et al., 2023; Ekiz et al., 2005).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Ekiz et al., 2005

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Authors
Ekiz, C., Agaoglu, L., Karakas, Z., Gurel, N., & Yalcin, I.
Affiliations
Istanbul University-Cerrahpaşa (TR)
Venue
The Hematology Journal
Publisher
Springer Science and Business Media LLC
Published
2005
Volume
5
Issue
7
Pages
579-583
ISSN
  • 1466-4860 (ISSN-L)
  • 1476-5632
DOI
10.1038/sj.thj.6200574
OpenAlex
W2052526882
Cited by
308
References
4
Citations by year
2026: 4 · 2025: 13 · 2024: 37 · 2023: 19 · 2022: 20 · 2021: 22 · 2020: 24 · 2019: 15 · 2018: 12 · 2017: 22 · 2016: 14 · 2015: 19 · 2014: 13 · 2013: 14 · 2012: 9
FWCI
3.70
Type
journal article
Language
en
Open access
closed
Locations
  • The Hematology Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
iron deficiency anemia, immune function, interleukin-6, T cell subsets, neutrophil respiratory burst, phagocytic activity, IgG4, humoral immunity, cell-mediated immunity, children
MeSH terms
Child, Preschool, Disease Susceptibility, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Infant, Infections, Reference Values, Antigens, CD, Interleukin-6, T-Lymphocyte Subsets, Respiratory Burst, Lymphocyte Count, Anemia, Iron-Deficiency

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