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Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor
Open accessAbstract
IRE1 plays an essential role in the endoplasmic reticulum (ER) stress response in yeast and mammals. We found that a double mutant of Arabidopsis IRE1A and IRE1B (ire1a/ire1b) is more sensitive to the ER stress inducer tunicamycin than the wild-type. Transcriptome analysis revealed that genes whose induction was reduced in ire1a/ire1b largely overlapped those in the bzip60 mutant. We observed that the active form of bZIP60 protein detected in the wild-type was missing in ire1a/ire1b. We further demonstrated that bZIP60 mRNA is spliced by ER stress, removing 23 ribonucleotides and therefore causing a frameshift that replaces the C-terminal region of bZIP60 including the transmembrane domain (TMD) with a shorter region without a TMD. This splicing was detected in ire1a and ire1b single mutants, but not in the ire1a/ire1b double mutant. We conclude that IRE1A and IRE1B catalyse unconventional splicing of bZIP60 mRNA to produce the active transcription factor.
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Cites
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,730
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,296
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana
Alonso, J. M., Stepanova, A. N., Leisse, T. J., Kim, C. J., Chen, H., Shinn, P., Stevenson, D. K., Zimmerman, J., Barajas, P., Cheuk, R., et al. (2003) · Science · doi:10.1126/science.1086391 · Cited by 5,102
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,039
Chomczynski, P., & Sacchi, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.83 · Cited by 2,076
Haze, K., Yoshida, H., Yanagi, H., Yura, T., & Mori, K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3787 · Cited by 2,069
[9] TM4 Microarray Software Suite
Saeed, A. I., Bhagabati, N. K., Braisted, J. C., Liang, W., Sharov, V., Howe, E. A., Li, J., Thiagarajan, M., White, J. A., & Quackenbush, J. (2006) · Methods in Enzymology · doi:10.1016/s0076-6879(06)11009-5 · Cited by 1,983
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00133-7 · Cited by 1,871
Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,338
Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response
Hollien, J., & Weissman, J. S. (2006) · Science · doi:10.1126/science.1129631 · Cited by 1,317
Shamu, C. E., & Walter, P. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00666.x · Cited by 1,264
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
Hollien, J., Lin, J. H., Li, H., Stevens, N., Walter, P., & Weissman, J. S. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903014 · Cited by 1,030
Cox, J. S., & Walter, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81360-4 · Cited by 1,028
Sidrauski, C., & Walter, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80369-4 · Cited by 899
PROSITE, a protein domain database for functional characterization and annotation
Sigrist, C. J. A., Cerutti, L., de Castro, E., Langendijk-Genevaux, P. S., Bulliard, V., Bairoch, A., & Hulo, N. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp885 · Cited by 858
Rosso, M. G., Li, Y., Strizhov, N., Reiss, B., Dekker, K., & Weisshaar, B. (2003) · Plant Molecular Biology · doi:10.1023/b:plan.0000009297.37235.4a · Cited by 747
Goda, H., Sasaki, E., Akiyama, K., Maruyama‐Nakashita, A., Nakabayashi, K., Li, W., Ogawa, M., Yamauchi, Y., Preston, J., Aoki, K., et al. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03510.x · Cited by 509
Self-citationDeng, Y., Humbert, S., Liu, J.-X., Srivastava, R., Rothstein, S. J., & Howell, S. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102117108 · Cited by 473
Liu, J.-X., Srivastava, R., Che, P., & Howell, S. H. (2008) · The Plant Cell · doi:10.1105/tpc.106.050021 · Cited by 456
Yoshida, H., Oku, M., Suzuki, M., & Mori, K. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508145 · Cited by 415
Mori, K., Kawahara, T., Yoshida, H., Yanagi, H., & Yura, T. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.d01-274.x · Cited by 364
Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA
Yanagitani, K., Kimata, Y., Kadokura, H., & Kohno, K. (2011) · Science · doi:10.1126/science.1197142 · Cited by 362
Iwata, Y., & Koizumi, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408941102 · Cited by 352
Self-citationTranslational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
Iwawaki, T., Hosoda, A., Okuda, T., Kamigori, Y., Nomura-Furuwatari, C., Kimata, Y., Tsuru, A., & Kohno, K. (2001) · Nature Cell Biology · doi:10.1038/35055065 · Cited by 308
Iwata, Y., Fedoroff, N. V., & Koizumi, N. (2008) · The Plant Cell · doi:10.1105/tpc.108.061002 · Cited by 306
Self-citationKimata, Y., Ishiwata-Kimata, Y., Ito, T., Hirata, A., Suzuki, T., Oikawa, D., Takeuchi, M., & Kohno, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704166 · Cited by 300
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
Kimata, Y., Oikawa, D., Shimizu, Y., Ishiwata-Kimata, Y., & Kohno, K. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405153 · Cited by 280
Che, P., Bussell, J. D., Zhou, W., Estavillo, G. M., Pogson, B. J., & Smith, S. M. (2010) · Science Signaling · doi:10.1126/scisignal.2001140 · Cited by 269
Koizumi, N., Martinez, I. M., Kimata, Y., Kohno, K., Sano, H., & Chrispeels, M. J. (2001) · Plant Physiology · doi:10.1104/pp.010636 · Cited by 244
Self-citationPrediction of RNA secondary structure using generalized centroid estimators
Hamada, M., Kiryu, H., Sato, K., Mituyama, T., & Asai, K. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btn601 · Cited by 233
Endoplasmic Reticulum Quality Control and the Unfolded Protein Response: Insights from Plants
Vitale, A., & Boston, R. S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00780.x · Cited by 192
Mori, K., Ogawa, N., Kawahara, T., Yanagi, H., & Yura, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050010197 · Cited by 180
Yanagitani, K., Imagawa, Y., Iwawaki, T., Hosoda, A., Saito, M., Kimata, Y., & Kohno, K. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.033 · Cited by 166
Lu, D., & Christopher, D. A. (2008) · Molecular Genetics and Genomics · doi:10.1007/s00438-008-0356-z · Cited by 146
Tajima, H., Iwata, Y., Iwano, M., Takayama, S., & Koizumi, N. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.021 · Cited by 125
Self-citationUnconventional Splicing of HAC1/ERN4 mRNA Required for the Unfolded Protein Response
Kawahara, T., Yanagi, H., Yura, T., & Mori, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1802 · Cited by 91
Transcriptomic response of Arabidopsis thaliana to tunicamycin-induced endoplasmic reticulum stress
Iwata, Y., Sakiyama, M., Lee, M., & Koizumi, N. (2010) · Plant Biotechnology · doi:10.5511/plantbiotechnology.27.161 · Cited by 48
Self-citationIwata, Y., YONEDA, M., Yanagawa, Y., & Koizumi, N. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80779 · Cited by 46
Self-citationAnalysis of a Transcription Factor Using Transient Assay in Arabidopsis Protoplasts
Iwata, Y., Lee, M., & Koizumi, N. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-154-3_6 · Cited by 19
Self-citation
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Maurel, M., Chevet, E., Tavernier, J., & Gerlo, S. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.008 · Cited by 631
Endoplasmic Reticulum Stress Responses in Plants
Howell, S. H. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120053 · Cited by 560
Endoplasmic reticulum stress and pulmonary hypertension
Hu, Y., Yang, W., Xie, L., Liu, T., Liu, H., & Liu, B. (2020) · Pulmonary Circulation · doi:10.1177/2045894019900121 · Cited by 21
Metadata
- Authors
- Nagashima, Y., Mishiba, K.-I., Suzuki, E., Shimada, Y., Iwata, Y., & Koizumi, N.
- Venue
- Scientific Reports
- Published
- 2011-07-01
- Volume
- 1
- Issue
- 1
- Pages
- 29-29
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2017313942
- Cited by
- 337
- References
- 41
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- gold
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