Transplantation of mesenchymal stem cells from young donors delays aging in mice
Open accessAbstract
Increasing evidence suggests that the loss of functional stem cells may be important in the aging process. Our experiments were originally aimed at testing the idea that, in the specific case of age-related osteoporosis, declining function of osteogenic precursor cells might be at least partially responsible. To test this, aging female mice were transplanted with mesenchymal stem cells from aged or young male donors. We find that transplantation of young mesenchymal stem cells significantly slows the loss of bone density and, surprisingly, prolongs the life span of old mice. These observations lend further support to the idea that age-related diminution of stem cell number or function may play a critical role in age-related loss of bone density in aging animals and may be one determinant of overall longevity.
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Many studies have shown that the number and function of different somatic cell populations declines with age, which diminishes the regenerative potential of tissues and organs.
“Many studies have shown that the number and function of different somatic cell populations declines with age, which diminishes the regenerative potential of tissues and organs.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [358]
The Discussion reports age-related declines in osteogenic progenitor cells and their function, and describes impaired migration in several other cell types. It says impaired BMSC migration may impede tissue and organ regeneration, but does not establish the claimed decline in the number of different cell populations or state the broad regenerative consequence as a demonstrated fact. The copy provides no page numbers for these passages. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThere is limited evidence that loss of stem cell function is a major driver of age-related pathology and shortened lifespan.
“However, there is limited evidence that loss of stem cell function is a major driver of age-related pathology and shortened lifespan.355–358”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [358]
The Abstract (page not available) reports that young stem-cell transplantation slowed bone-density loss and prolonged lifespan in old mice, supporting a possible role for stem-cell function in both outcomes. But it describes stem-cell decline as a possible critical factor in bone-density loss and one determinant of longevity; it does not establish loss of stem-cell function as a major driver of age-related pathology generally or of shortened lifespan. (LLM, conf=0.86)
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- Authors
- Shen, J., Tsai, Y.-T., DiMarco, N. M., Long, M. A., Sun, X., & Tang, L.
- Affiliations
- The University of Texas at Arlington (US)
- Texas Woman's University (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Tang, Liping
- Venue
- Scientific Reports
- Published
- 2011-08-18
- Volume
- 1
- Issue
- 1
- Pages
- 67-67
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3216554
- OpenAlex
- W2167729694
- Cited by
- 117
- References
- 51
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R01EB007271)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- mesenchymal stem cells, stem cell transplantation, aging, senile osteoporosis, bone mineral density, longevity, lifespan, donor age, bone marrow
- MeSH terms
- Aging, Animals, Cell Movement, Female, Longevity, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Bone Density, Mesenchymal Stem Cell Transplantation, Mice
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