Drug addiction is associated with leukocyte telomere length
Open accessAbstract
Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Telomere length is known to be associated with ageing and age-related diseases. To study the impairment of telomeres induced by drug abuse, we conducted an association study in the Chinese Han population. Multivariate linear regression analyses were performed to evaluate the correlation of leukocyte telomere length (LTL) with addiction control status adjusted for age and gender. The results showed that drug abusers exhibited significantly shorter LTLs than controls (P = 1.32e-06). The time before relapse also presented an inverse correlation with LTL (P = 0.02). Drug abusers who had used heroin and diazepam displayed a shorter LTL than those taking other drugs (P = 0.018 and P = 0.009, respectively). Drug abusers who had ingested drugs via snuff exhibited longer LTLs than those using other methods (P = 0.02). These observations may offer a partial explanation for the effects of drug addiction on health.
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Preliminary reports suggest that alcohol and certain types of substance abuse may be associated with altered LTL.
“Moreover, several preliminary reports suggest that alcohol and certain types of substance abuse may be associated with altered LTL (Pavanello et al., 2011; Yang et al., 2013).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Yang et al., 2013
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- Authors
- Yang, Z., Ye, J., Li, C., Zhou, D., Shen, Q., Wu, J., Cao, L., Wang, T., Cui, D., He, S., Qi, G., He, L., & Liu, Y.
- Affiliations
- Fudan University (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- He, Lin
- Liu, Yun
- ORCID
- Venue
- Scientific Reports
- Published
- 2013-03-26
- Volume
- 3
- Issue
- 1
- Pages
- 1542-1542
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3607895
- OpenAlex
- W2030849013
- Cited by
- 55
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 12 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Natural Science Foundation of China (973 Program, 2010CB529600, 81121001, 2012BAI01B09)
- Wu Jieping Medical Foundation (320.67001118)
- National Key Research and Development Program of China (2012BAI01B09, 2010CB529600, 2011CB505405, 2011CB504000)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- drug addiction, leukocyte telomere length, telomere shortening, heroin, diazepam, relapse, snuff use, Han Chinese, genome stability
- MeSH terms
- Adult, Analgesics, Opioid, Heroin, Diazepam, Female, Humans, Hypnotics and Sedatives, Leukocytes, Male, Cohort Studies, Multivariate Analysis, Linear Models, Telomere, Substance-Related Disorders, Telomere Shortening
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