The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Uterine Selection of Human Embryos at Implantation
Open accessAbstract
Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first breach the endometrial epithelium and embed in the decidualizing stroma before being rejected via mechanisms that are poorly understood. Here we show that developmentally impaired human embryos elicit an endoplasmic stress response in human decidual cells. A stress response was also evident upon in vivo exposure of mouse uteri to culture medium conditioned by low-quality human embryos. By contrast, signals emanating from developmentally competent embryos activated a focused gene network enriched in metabolic enzymes and implantation factors. We further show that trypsin, a serine protease released by pre-implantation embryos, elicits Ca(2+) signaling in endometrial epithelial cells. Competent human embryos triggered short-lived oscillatory Ca(2+) fluxes whereas low-quality embryos caused a heightened and prolonged Ca(2+) response. Thus, distinct positive and negative mechanisms contribute to active selection of human embryos at implantation.
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Cites
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Cited by
Menstruation: science and society
Critchley, H. O. D., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 448
Frozen embryo transfer: a review on the optimal endometrial preparation and timing
Mackens, S., Santos-Ribeiro, S., van de Vijver, A., Racca, A., Van Landuyt, L., Tournaye, H., & Blockeel, C. (2017) · Human Reproduction · doi:10.1093/humrep/dex285 · Cited by 361
The Human Endometrium as a Sensor of Embryo Quality1
Macklon, N. S., & Brosens, J. J. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.122846 · Cited by 317
Self-citation(2020) · doi:10.1038/s42003-020-0763-1 · Cited by 309
Embryo–epithelium interactions during implantation at a glance
Aplin, J. D., & Ruane, P. T. (2017) · Journal of Cell Science · doi:10.1242/jcs.175943 · Cited by 266
Metadata
- Authors
- Brosens, J. J., Salker, M. S., Teklenburg, G., Nautiyal, J., Salter, S., Lucas, E. S., Steel, J. H., Christian, M., Chan, Y.-W., Boomsma, C. M., Moore, J. D., Hartshorne, G. M., Šućurović, S., Mulac-Jericevic, B., Heijnen, C. J., Quenby, S., Groot Koerkamp, M. J., Holstege, F. C. P., Shmygol, A., & Macklon, N. S.
- Venue
- Scientific Reports
- Published
- 2014-02-06
- Volume
- 4
- Issue
- 1
- Pages
- 3894-3894
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2103183894
- Cited by
- 329
- References
- 48
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Brosens, J. J., Salker, M. S., Teklenburg, G., Nautiyal, J., Salter, S., Lucas, E. S., Steel, J. H., Christian, M., Chan, Y.-W., Boomsma, C. M., Moore, J. D., Hartshorne, G. M., Šućurović, S., Mulac-Jericevic, B., Heijnen, C. J., Quenby, S., Groot Koerkamp, M. J., Holstege, F. C. P., Shmygol, A., & Macklon, N. S. (2014). Uterine Selection of Human Embryos at Implantation. Scientific Reports. https://doi.org/10.1038/srep03894
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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