The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Human Endometrium as a Sensor of Embryo Quality1
Abstract
Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed.
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Citations
Cites
Incidence of early loss of pregnancy
Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354
Genetic conflicts in human pregnancy
Haig, D. (1993) · The Quarterly Review of Biology · doi:10.1086/418300 · Cited by 1,253 · cited 1×
“However, it is incontrovertible that the rather peculiar human embryo imposes an important reproductive challenge: how to facilitate implantation while simultaneously safeguarding the mother against prolonged investment in potentially developmentally abnormal embryos [15].”
BackgroundConverging concepts of protein folding in vitro and in vivo
Hartl, F. U., & Hayer-Hartl, M. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1591 · Cited by 1,185
Molecular Cues to Implantation
Dey, S. K., Lim, H., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,105
Time of Implantation of the Conceptus and Loss of Pregnancy
Wilcox, A. J., Baird, D. D., & Weinberg, C. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402304 · Cited by 1,081
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress
Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.-P., Skepper, J. N., & Burton, G. J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64849-3 · Cited by 1,057
Chromosome instability is common in human cleavage-stage embryos
Vanneste, E., Voet, T., Le Caignec, C., Ampe, M., Konings, P., Melotte, C., Debrock, S., Amyere, M., Vikkula, M., Schuit, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.1924 · Cited by 880
Conception to ongoing pregnancy: the 'black box' of early pregnancy loss
Macklon, N. S. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.4.333 · Cited by 783
Self-citationDecidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives
Gellersen, B., Brosens, I., & Brosens, J. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-991042 · Cited by 587
Self-citationDas, S. K., Wang, X.-N., Paria, B. C., Damm, D., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 569
Cited by
Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis
Craciunas, L., Gallos, I., Chu, J., Bourne, T., Quenby, S., Brosens, J. J., & Coomarasamy, A. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmy044 · Cited by 572
Self-citationMenstruation: science and society
Critchley, H. O. D., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 448
Reproduction at an advanced maternal age and maternal health
Sauer, M. V. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.03.004 · Cited by 379
Embryo–epithelium interactions during implantation at a glance
Aplin, J. D., & Ruane, P. T. (2017) · Journal of Cell Science · doi:10.1242/jcs.175943 · Cited by 266
Regulation of androgen action during establishment of pregnancy
Gibson, D. A., Simitsidellis, I., & Saunders, P. T. K. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0027 · Cited by 42
Metadata
- Authors
- Macklon, N. S., & Brosens, J. J.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-01
- Volume
- 91
- Issue
- 4
- Pages
- 98-98
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2117371378
- Cited by
- 317
- References
- 43
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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