The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry
Open accessAbstract
Interest in extracellular vesicle biology has exploded in the past decade, since these microstructures seem endowed with multiple roles, from blood coagulation to inter-cellular communication in pathophysiology. In order for microparticle research to evolve as a preclinical and clinical tool, accurate quantification of microparticle levels is a fundamental requirement, but their size and the complexity of sample fluids present major technical challenges. Flow cytometry is commonly used, but suffers from low sensitivity and accuracy. Use of Amnis ImageStream X Mk II imaging flow cytometer afforded accurate analysis of calibration beads ranging from 1 μm to 20 nm; and microparticles, which could be observed and quantified in whole blood, platelet-rich and platelet-free plasma and in leukocyte supernatants. Another advantage was the minimal sample preparation and volume required. Use of this high throughput analyzer allowed simultaneous phenotypic definition of the parent cells and offspring microparticles along with real time microparticle generation kinetics. With the current paucity of reliable techniques for the analysis of microparticles, we propose that the ImageStream X could be used effectively to advance this scientific field.
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Delivery of chemotherapeutic drugs in tumour cell-derived microparticles
Tang, K., Zhang, Y., Zhang, H., Xu, P., Liu, J., Ma, J., Lv, M., Li, D., Katirai, F., Shen, G.-X., et al. (2012) · Nature Communications · doi:10.1038/ncomms2282 · Cited by 453
Foladori, P., Quaranta, A., & Ziglio, G. (2008) · Water Research · doi:10.1016/j.watres.2008.06.026 · Cited by 79
Cited by
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón‐Pérez, J. M., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12093 · Cited by 404
Leoni, G., Neumann, P.-A., Kamaly, N., Quiros, M., Nishio, H., Jones, H. R., Sumagin, R., Hilgarth, R. S., Alam, A., Fredman, G., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76693 · Cited by 354
Self-citationNeutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
Headland, S. E., Jones, H. R., Norling, L. V., Kim, A., Souza, P. R., Corsiero, E., Gil, C. D., Nerviani, A., Dell’Accio, F., Pitzalis, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac5608 · Cited by 319
Self-citationCandida albicans biofilm–induced vesicles confer drug resistance through matrix biogenesis
Zarnowski, R., Sanchez, H., Covelli, A. S., Dominguez, E., Jaromin, A., Bernhardt, J., Mitchell, K. F., Heiss, C., Azadi, P., Mitchell, A., et al. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006872 · Cited by 260
Metadata
- Authors
- Headland, S. E., Jones, H. R., D'Sa, A. S. V., Perretti, M., & Norling, L. V.
- Venue
- Scientific Reports
- Published
- 2014-06-10
- Volume
- 4
- Issue
- 1
- Pages
- 5237-5237
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2014869316
- Cited by
- 211
- References
- 2
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- gold
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