The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
Open accessAbstract
Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understanding of the epithelial restitution process has potential for improving the development of therapeutics. In this work, we demonstrate that endogenous annexin A1 (ANXA1) is released as a component of extracellular vesicles (EVs) derived from intestinal epithelial cells, and these ANXA1-containing EVs activate wound repair circuits. Compared with healthy controls, patients with active inflammatory bowel disease had elevated levels of secreted ANXA1-containing EVs in sera, indicating that ANXA1-containing EVs are systemically distributed in response to the inflammatory process and could potentially serve as a biomarker of intestinal mucosal inflammation. Local intestinal delivery of an exogenous ANXA1 mimetic peptide (Ac2-26) encapsulated within targeted polymeric nanoparticles (Ac2-26 Col IV NPs) accelerated healing of murine colonic wounds after biopsy-induced injury. Moreover, one-time systemic administration of Ac2-26 Col IV NPs accelerated recovery following experimentally induced colitis. Together, our results suggest that local delivery of proresolving peptides encapsulated within nanoparticles may represent a potential therapeutic strategy for clinical situations characterized by chronic mucosal injury, such as is seen in patients with IBD.
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Cites
Exploring the full spectrum of macrophage activation
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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
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Self-citationMetalloproteinases and their natural inhibitors in inflammation and immunity
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“Recent studies have identified a number of mediators that play an active role in the resolution of inflammation, including ANXA1, lipoxins, resolvins, protectins, and maresins (3, 34–37).”
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Annexin A1 regulates intestinal mucosal injury, inflammation, and repair
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Cited by
Resolution of Inflammation: What Controls Its Onset?
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00160 · Cited by 638
Self-citationSynthetic hydrogels for human intestinal organoid generation and colonic wound repair
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Self-citationNeutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
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Self-citationGenetics and Pathogenesis of Inflammatory Bowel Disease
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PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery
Cruz-Acuña, R., Quirós, M., Huang, S., Siuda, D., Spence, J. R., Nusrat, A., & García, A. J. (2018) · Nature Protocols · doi:10.1038/s41596-018-0036-3 · Cited by 168
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Metadata
- Authors
- Leoni, G., Neumann, P.-A., Kamaly, N., Quiros, M., Nishio, H., Jones, H. R., Sumagin, R., Hilgarth, R. S., Alam, A., Fredman, G., Argyris, I., Rijcken, E., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Farokhzad, O. C., Neish, A. S., & Nusrat, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-02-09
- Volume
- 125
- Issue
- 3
- Pages
- 1215-1227
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1982159359
- Cited by
- 354
- References
- 10
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Leoni, G., Neumann, P.-A., Kamaly, N., Quiros, M., Nishio, H., Jones, H. R., Sumagin, R., Hilgarth, R. S., Alam, A., Fredman, G., Argyris, I., Rijcken, E., Kusters, D., Reutelingsperger, C., Perretti, M., Parkos, C. A., Farokhzad, O. C., Neish, A. S., & Nusrat, A. (2015). Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Journal of Clinical Investigation. https://doi.org/10.1172/jci76693
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
