Delivery of chemotherapeutic drugs in tumour cell-derived microparticles
Open accessAbstract
Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100-1,000 nanometres that are shed by cells in response to various physiological and artificial stimuli. Here we demonstrate that tumour cell-derived microparticles can be used as vectors to deliver chemotherapeutic drugs. We show that tumour cells incubated with chemotherapeutic drugs package these drugs into microparticles, which can be collected and used to effectively kill tumour cells in murine tumour models without typical side effects. We describe several mechanisms involved in this process, including uptake of drug-containing microparticles by tumour cells, synthesis of additional drug-packaging microparticles by these cells that contribute to the cytotoxic effect and the inhibition of drug efflux from tumour cells. This study highlights a novel drug delivery strategy with potential clinical application.
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Exosomes pre-loaded with cisplatin significantly decrease liver or kidney toxicities and suppress tumors in ovarian cancer mice xenograft model.
“Tang et al. showed another example that exosomes pre-loaded with cisplatin could significantly decrease liver or kidney toxicities and suppress tumors in ovarian cancer mice xenograft model [58].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [58]
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- Authors
- Tang, K., Zhang, Y., Zhang, H., Xu, P., Liu, J., Ma, J., Lv, M., Li, D., Katirai, F., Shen, G.-X., Zhang, G., Feng, Z.-H., Ye, D., & Huang, B.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Huang, Bo
- Venue
- Nature Communications
- Published
- 2012-12-18
- Volume
- 3
- Issue
- 1
- Pages
- 1282-1282
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1986328483
- Cited by
- 453
- References
- 59
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 48 · 2023: 36 · 2022: 55 · 2021: 52 · 2020: 55 · 2019: 49 · 2018: 34 · 2017: 28 · 2016: 21 · 2015: 20 · 2014: 12 · 2013: 5
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- McMaster University
- National Natural Science Foundation of China (30911120482)
- Chinese Academy of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- drug delivery, chemotherapy, pharmaceutical packaging, drug efflux inhibition, anticancer agents, mouse tumor model
- MeSH terms
- Animals, Antineoplastic Agents, Cell Membrane, Cisplatin, Drug Carriers, Female, Liver Neoplasms, Methotrexate, Mice, Inbred BALB C, Neoplasms, Neoplasms, Experimental, Ovarian Neoplasms, Mice, SCID, Cell Line, Tumor, Mice, Cell-Derived Microparticles
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