Identification of IL6 as a susceptibility gene for major depressive disorder
Open accessAbstract
Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed a comprehensive genetic study to determine the association between the gene encoding IL6 (IL6) and MDD in Han Chinese. There were 50 drug-naïve MDD patients and 50 healthy controls undergoing an mRNA expression study. A sample of 772 patients with MDD and 759 healthy controls were used for genetic analysis. Next, we performed an eQTL analysis to identify whether risk SNP(s) is associated with IL6 expression in brain. Our results showed that patients with MDD have higher levels of IL6 than healthy controls (P = 0.008). The SNP rs1800797 has a significant association with MDD (P = 0.01) in a dominant model. The eQTL analysis showed a marginally significant association between the rs1800797 and IL6 expression in the frontal cortex (P = 0.087). Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD. Further investigations are required to evaluate this association in larger samples to increase statistical power, and to examine the correlation between rs1800797 and IL6 methylation patterns.
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IL6 polymorphisms are associated with depression.
“and by the association of IL6 polymorphisms in individuals with depression (Zhang et al., 2016).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Zhang et al., 2016
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- Authors
- Zhang, C., Wu, Z., Zhao, G., Wang, F., & Fang, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhang, Chen
- Fang, Yiru
- Venue
- Scientific Reports
- Published
- 2016-08-09
- Volume
- 6
- Issue
- 1
- Pages
- 31264-31264
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4977523
- OpenAlex
- W2511596774
- Cited by
- 46
- References
- 56
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 1
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81,471,358)
- Shanghai Municipal Education Commission (20152530)
- Science and Technology Commission of Shanghai Municipality (201540029, 20152530)
- Health and Family Planning Commission of Sichuan Province (201540029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- interleukin-6, major depressive disorder, genetic susceptibility, rs1800797, expression quantitative trait loci, brain gene expression, frontal cortex, Han Chinese, mRNA expression, DNA methylation
- MeSH terms
- Adult, Brain, China, Major Depressive Disorder, Female, Frontal Lobe, Genotype, Humans, Male, Risk, RNA, Messenger, Smoking, Cohort Studies, Interleukin-6, Case-Control Studies, DNA Methylation, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Gene Expression Profiling, Quantitative Trait Loci, Asian People
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