The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying
Open accessAbstract
Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1 in epithelial mouse stomach cells is described. After receiving a single-dose of CIN, mice significantly reduce cumulative food intake and gastric emptying rates. Co-localization of TRPA1 and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN up-regulates expression of TRPA1 and Insulin receptor genes. Ghrelin secreted in the culture medium was quantified following CIN stimulation and we observe that octanoyl and total ghrelin are significantly lower than in control conditions. Additionally, obese mice fed for five weeks with CIN-containing diet significantly reduce their cumulative body weight gain and improve glucose tolerance without detectable modification of insulin secretion. Finally, in adipose tissue up-regulation of genes related to fatty acid oxidation was observed. Taken together, the results confirm anti-hyperglycemic and anti-obesity effects of CIN opening a new approach to investigate how certain spice derived compounds regulate endogenous ghrelin release for therapeutic intervention.
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Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034916b · Cited by 561
Cinnamaldehyde--a potential antidiabetic agent
Subash Babu, P., Prabuseenivasan, S., & Ignacimuthu, S. (2007) · Phytomedicine · doi:10.1016/j.phymed.2006.11.005 · Cited by 477
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
Nozawa, K., Kawabata-Shoda, E., Doihara, H., Kojima, R., Okada, H., Mochizuki, S., Sano, Y., Inamura, K., Matsushime, H., Koizumi, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805323106 · Cited by 399
Janssen, S., Laermans, J., Verhulst, P.-J., Thijs, T., Tack, J., & Depoortere, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011508108 · Cited by 317
Solomon, T. P. J., & Blannin, A. K. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-0986-9 · Cited by 89
Cited by
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
Beumer, J., Artegiani, B., Post, Y., Reimann, F., Gribble, F., Nguyen, T. N., Zeng, H., Van den Born, M., Van Es, J. H., & Clevers, H. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0143-y · Cited by 287
Kaur, N., Gupta, P., Saini, V., Sherawat, S., Gupta, S., Dua, A., Kumar, V., Injeti, E., & Mittal, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27348 · Cited by 40
Metadata
- Authors
- Camacho, S., Michlig, S., de Senarclens-Bezençon, C., Meylan, J., Meystre, J., Pezzoli, M., Markram, H., & le Coutre, J.
- Venue
- Scientific Reports
- Published
- 2015-01-21
- Volume
- 5
- Issue
- 1
- Pages
- 7919-7919
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2074021102
- Cited by
- 189
- References
- 6
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Camacho, S., Michlig, S., de Senarclens-Bezençon, C., Meylan, J., Meystre, J., Pezzoli, M., Markram, H., & le Coutre, J. (2015). Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying. Scientific Reports. https://doi.org/10.1038/srep07919
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
