Cinnamaldehyde--a potential antidiabetic agent
Abstract
Cinnamonum zeylanicum (cinnamon) is widely used in traditional system of medicine to treat diabetes in India. The present study was carried out to isolate and identify the putative antidiabetic compounds based on bioassay-guided fractionation; the compound identified decreased the plasma glucose levels. The active compound was purified by repeat column and structure of cinnamaldehyde was determined on the basis of chemical and physiochemical evidence. The LD(50) value of cinnamaldehyde was determined as 1850+/-37 mg/kg bw. Cinnamaldehyde was administered at different doses (5, 10 and 20 mg/kg bw) for 45 days to streptozotocin (STZ) (60 mg/kg bw)-induced male diabetic wistar rats. It was found that plasma glucose concentration was significantly (p<0.05) decreased in a dose-dependent manner (63.29%) compared to the control. In addition, oral administration of cinnamaldehyde (20 mg/kg bw) significantly decreased glycosylated hemoglobin (HbA(1C)), serum total cholesterol, triglyceride levels and at the same time markedly increased plasma insulin, hepatic glycogen and high-density lipoprotein-cholesterol levels. Also cinnamaldehyde restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal. Administration of glibenclamide, a reference drug (0.6 mg/kg bw) also produced a significant (p<0.05) reduction in blood glucose concentration in STZ-induced diabetic rats. The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats.
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Cinnamaldehyde, the main component of cinnamon, has lipid-lowering capacities.
“Cinnamaldehyde, the main component of cinnamon, has also been shown to have lipid-lowering capacities [30].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [30]
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- Authors
- Subash Babu, P., Prabuseenivasan, S., & Ignacimuthu, S.
- Affiliations
- Loyola College (IN)
- Corresponding author
- Ignacimuthu, S.
- ORCID
- Ignacimuthu, S.
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 14
- Issue
- 1
- Pages
- 15-22
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W2075590923
- Cited by
- 477
- References
- 42
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 24 · 2023: 30 · 2022: 31 · 2021: 42 · 2020: 36 · 2019: 26 · 2018: 36 · 2017: 36 · 2016: 19 · 2015: 33 · 2014: 26 · 2013: 19 · 2012: 25
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute for Basic Science
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Keywords
- cinnamaldehyde, cinnamon, Cinnamomum zeylanicum, antidiabetic activity, hypoglycemic effect, hypolipidemic effect, streptozotocin-induced diabetes, plasma glucose, HbA1c, serum lipids, insulin, liver glycogen, liver enzymes, glibenclamide, bioassay-guided fractionation
- MeSH terms
- Acrolein, Administration, Oral, Alanine Transaminase, Alkaline Phosphatase, Animals, Aspartate Aminotransferases, Blood Glucose, Cholesterol, Cinnamomum zeylanicum, Diabetes Mellitus, Experimental, Dose-Response Relationship, Drug, Glycogen, Glycated Hemoglobin, Hypoglycemic Agents, Insulin, L-Lactate Dehydrogenase, Cholesterol, HDL, Male, Phytotherapy, Plant Extracts, Streptozocin, Triglycerides, Rats, Wistar, Plant Bark, Rats
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