The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line
Open accessAbstract
Mechanical interaction between cells - specifically distortion of tensional homeostasis-emerged as an important aspect of breast cancer genesis and progression. We investigated the biophysical characteristics of mechanosensitive ion channels (MSCs) in the malignant MCF-7 breast cancer cell line. MSCs turned out to be the most abundant ion channel species and could be activated by negative pressure at the outer side of the cell membrane in a saturable manner. Assessing single channel conductance (GΛ) for different monovalent cations revealed an increase in the succession: Li(+) < Na(+) < K(+) ≈Rb(+) ≈ Cs(+). Divalent cations permeated also with the order: Ca(2+) < Ba(2+). Comparison of biophysical properties enabled us to identify MSCs in MCF-7 as ion channels formed by the Piezo1 protein. Using patch clamp technique no functional MSCs were observed in the benign MCF-10A mammary epithelial cell line. Blocking of MSCs by GsMTx-4 resulted in decreased motility of MCF-7, but not of MCF-10A cells, underscoring a possible role of Piezo1 in invasion and metastatic propagation. The role of Piezo1 in biology and progression of breast cancer is further substantiated by markedly reduced overall survival in patients with increased Piezo1 mRNA levels in the primary tumor.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Györffy, B., Lanczky, A., Eklund, A. C., Denkert, C., Budczies, J., Li, Q., & Szallasi, Z. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0674-9 · Cited by 4,169
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Mechanical compression drives cancer cells toward invasive phenotype
Tse, J. M., Cheng, G., Tyrrell, J. A., Wilcox-Adelman, S. A., Boucher, Y., Jain, R. K., & Munn, L. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118910109 · Cited by 631
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
McHugh, B. J., Murdoch, A., Haslett, C., & Sethi, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040346 · Cited by 169
Yang, X.-N., Lu, Y.-P., Liu, J.-J., Huang, J.-K., Liu, Y.-P., Xiao, C.-X., Jazag, A., Ren, J.-L., & Guleng, B. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3044-3 · Cited by 112
Cited by
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?
Prevarskaya, N., Skryma, R., & Shuba, Y. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 484
Chen, X., Wanggou, S., Bodalia, A., Zhu, M., Dong, W., Fan, J. J., Yin, W. C., Min, H.-K., Hu, M., Draghici, D., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.046 · Cited by 401
Mechanisms and impact of altered tumour mechanics
Mohammadi, H., & Sahai, E. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0131-2 · Cited by 336
Mechanosensitive ion channels push cancer progression
Pethő, Z., Najder, K., Bulk, E., & Schwab, A. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.03.007 · Cited by 125
Metadata
- Authors
- Li, C., Rezania, S., Kammerer, S., Sokolowski, A., Devaney, T., Gorischek, A., Jahn, S., Hackl, H., Groschner, K., Windpassinger, C., Malle, E., Bauernhofer, T., & Schreibmayer, W.
- Venue
- Scientific Reports
- Published
- 2015-02-10
- Volume
- 5
- Issue
- 1
- Pages
- 8364-8364
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1996711923
- Cited by
- 166
- References
- 6
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line. https://app.cochat.ai/papers/10.1038/srep08364
- The paper
- Li, C., Rezania, S., Kammerer, S., Sokolowski, A., Devaney, T., Gorischek, A., Jahn, S., Hackl, H., Groschner, K., Windpassinger, C., Malle, E., Bauernhofer, T., & Schreibmayer, W. (2015). Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line. Scientific Reports. https://doi.org/10.1038/srep08364
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
