Mechanosensitive ion channels push cancer progression

Pethő, Zoltán; Najder, Karolina; Bulk, Etmar; Schwab, Albrecht

doi:10.1016/j.ceca.2019.03.007

Cited by 125Cellular Mechanics and InteractionsIon Channels and ReceptorsErythrocyte Function and Pathophysiology

Mechanosensitive ion channels push cancer progression

Pethő, Zoltán, Najder, Karolina, Bulk, Etmar, Schwab, Albrecht·2019·Cell Calcium

DOI 10.1016/j.ceca.2019.03.007

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Abstract

In many cases, the mechanical properties of a tumor are different from those of the host tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their microenvironment, by altering cell migration, proliferation, extracellular matrix remodeling and metastatic spread. Cancer cells sense mechanical stimuli such as tissue stiffness, shear stress, tissue pressure of the extracellular space (outside-in mechanosensation). These mechanical cues are transduced into a cellular response (e. g. cell migration and proliferation; inside-in mechanotransduction) or to a response affecting the microenvironment (e. g. inducing a fibrosis or building up growth-induced pressure; inside-out mechanotransduction). These processes heavily rely on mechanosensitive membrane proteins, prominently ion channels. Mechanosensitive ion channels are involved in the Ca 2+-signaling of the tumor and stroma cells, both directly, by mediating Ca 2+ influx (e. g. Piezo and TRP channels), or indirectly, by maintaining the electrochemical gradient necessary for Ca 2+ influx (e. g. K 2P, K Ca channels). This review aims to discuss the diverse roles of mechanosenstive ion channels in cancer progression, especially those involved in Ca 2+-signaling, by pinpointing their functional relevance in tumor pathophysiology.

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Mechanically activated ion channels may respond to the deformation (strain) of the cell membrane rather than the force.
“Mechanically activated ion channels (e.g., Piezo, transient receptor potential channels) are sometimes referred to as “force sensors” but may respond to the deformation (strain) of the cell membrane rather than the force [26].”
From Fascia Mobility, Proprioception, and Myofascial Pain. (2021) · cites this paper as [26]

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Expression of Functional P2-Purinergic Receptors in Primary Cultures of Human Colorectal Carcinoma Cells
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NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment
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miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma
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TRPM7 is required for ovarian cancer cell growth, migration and invasion
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Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells
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The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein
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Mechanosensitive Cl− secretion in biliary epithelium mediated through TMEM16A
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Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis
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Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent
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Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis
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Iodine-131 Dose Dependent Gene Expression in Thyroid Cancers and Corresponding Normal Tissues Following the Chernobyl Accident
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The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer
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Expression of TRPC6 in benign and malignant human prostate tissues
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Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells
Fels, B., Nielsen, N., & Schwab, A. (2016) · European Biophysics Journal · doi:10.1007/s00249-016-1176-4 · Cited by 51 · see citing works
Self-citation
Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas
Okada, Y., Shirai, K., Miyajima, M., Reinach, P. S., Yamanaka, O., Sumioka, T., Kokado, M., Tomoyose, K., & Saika, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167200 · Cited by 51 · see citing works
Mechanism of Mechanosensitive Gating of the TREK-2 Potassium Channel
Brennecke, J. T., & de Groot, B. L. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.01.030 · Cited by 51 · see citing works
The Function of the Novel Mechanical Activated Ion Channel Piezo1 in the Human Osteosarcoma Cells
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Shear stress modulates endothelial KLF2 through activation of P2X4
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The role of TRPV4 in fibrosis
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A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis
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The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability
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pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer
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TRPC1-STIM1 activation modulates transforming growth factor β-induced epithelial-to-mesenchymal transition
Schaar, A., Sukumaran, P., Sun, Y., Dhasarathy, A., & Singh, B. B. (2016) · Oncotarget · doi:10.18632/oncotarget.12895 · Cited by 48 · see citing works
Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca2+-dependent and regulated by KCa3.1 K+ channels
Roach, K. M., Feghali‐Bostwick, C. A., Wulff, H., Amrani, Y., & Bradding, P. H. (2015) · Fibrogenesis & Tissue Repair · doi:10.1186/s13069-015-0022-0 · Cited by 48 · see citing works
Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells
Lepannetier, S., Zanou, N., Yerna, X., Emeriau, N., Dufour, I., Masquelier, J., Muccioli, G. G., Tajeddine, N., & Gailly, P. L. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.09.002 · Cited by 48 · see citing works
K Ca 3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II–Treated Rats
She, G., Ren, Y., Wang, Y., Hou, M., Wang, H., Gou, W., Lai, B., Lei, T., Du, X., & Deng, X. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010418 · Cited by 48 · see citing works
Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer
Innamaa, A., Jackson, L. M., Asher, V., Schalkwyk, G. V., Warren, A. Y., Keightley, A. M., Hay, D. P., Bali, A., Sowter, H., & Khan, R. N. (2013) · Clinical & Translational Oncology · doi:10.1007/s12094-013-1022-4 · Cited by 47 · see citing works
Curcumin Serves as a Human Kv1.3 Blocker to Inhibit Effector Memory T Lymphocyte Activities
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A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia
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Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma
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KCa3.1 ion channel: A novel therapeutic target for corneal fibrosis
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TRPV 4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus
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TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia
Nielsen, N., Kondratska, K., Ruck, T., Hild, B., Kovalenko, I., Schimmelpfennig, S., Welzig, J., Sargin, S., Lindemann, O., Christian, S., et al. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2057-0 · Cited by 45 · see citing works
Self-citation
Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron
Mamenko, M., Zaika, O., Boukelmoune, N., O’Neil, R. G., & Pochynyuk, O. M. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00485.2014 · Cited by 44 · see citing works
PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability
Suzuki, T., Muraki, Y., Hatano, N., Suzuki, H., & Muraki, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051452 · Cited by 42 · see citing works
BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK
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Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues
Qin, L., He, T., Chen, S., Yang, D., Yi, W., Cao, H., & Xiao, G. (2021) · Bone Research · doi:10.1038/s41413-021-00168-8 · Cited by 233 · see citing works
The hallmarks of cancer are also the hallmarks of wound healing
MacCarthy-Morrogh, L., & Martin, P. (2020) · Science Signaling · doi:10.1126/scisignal.aay8690 · Cited by 158 · see citing works
Beyond matrix stiffness: targeting force-induced cancer drug resistance
Kalli, M., Poskus, M. D., Stylianopoulos, T., & Zervantonakis, I. K. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.006 · Cited by 173 · see citing works
Mechanosensitive Piezo Channels in Cancer: Focus on altered Calcium Signaling in Cancer Cells and in Tumor Progression
Felice, D. D., & Alaimo, A. (2020) · Cancers · doi:10.3390/cancers12071780 · Cited by 112 · see citing works
Durotaxis: the mechanical control of directed cell migration
Espina, J. A., Marchant, C. L., & Barriga, E. H. (2021) · FEBS Journal · doi:10.1111/febs.15862 · Cited by 108 · see citing works
Fascia Mobility, Proprioception, and Myofascial Pain.
Langevin, H. M. (2021) · Life · doi:10.3390/life11070668 · Cited by 97 · see citing works
“, Piezo, transient receptor potential channels) are sometimes referred to as “force sensors” but may respond to the deformation (strain) of the cell membrane rather than the force [26].”
Background
Piezo1 and its inhibitors: Overview and perspectives
Thien, N. D., Hai-Nam, N., Anh, D. T., & Baecker, D. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116502 · Cited by 85 · see citing works
Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review
Li, J., Yan, Y., Sun, H., Liu, Y., Su, C., Chen, H., & Zhang, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00746 · Cited by 74 · see citing works
Targeting tumor interstitial fluid pressure: will it yield novel successful therapies for solid tumors?
Boeckelmann, L., & Schumacher, U. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1702974 · Cited by 76 · see citing works
Piezo1 and BKCa channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation
Jakob, D., Klesen, A., Allegrini, B., Darkow, E., Aria, D., Emig, R., Simón-Chica, A., Rog‐Zielinska, E. A., Guth, T. A., Beyersdorf, F., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.002 · Cited by 72 · see citing works
Identification of PIEZO1 as a potential prognostic marker in gliomas
Zhou, W., Liu, X., van Wijnbergen, J. W., Yuan, L., Liu, Y., Zhang, C., & Jia, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-72886-8 · Cited by 71 · see citing works
Piezo channels in the urinary system
Li, X., Hu, J., Zhao, X.-D., Li, J., & Chen, Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00777-1 · Cited by 61 · see citing works
Machine Learning in Biomaterials, Biomechanics/Mechanobiology, and Biofabrication: State of the Art and Perspective
Wu, C., Xu, Y., Fang, J., & Li, Q. (2024) · Archives of Computational Methods in Engineering · doi:10.1007/s11831-024-10100-y · Cited by 69 · see citing works
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
Moparthi, L., & Zygmunt, P. M. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102255 · Cited by 61 · see citing works
TRPV Protein Family—From Mechanosensing to Cancer Invasion
Kärki, T., & Tojkander, S. (2021) · Biomolecules · doi:10.3390/biom11071019 · Cited by 59 · see citing works
Targeting the Calcium Signalling Machinery in Cancer
Bruce, J. I. E., & James, A. D. (2020) · Cancers · doi:10.3390/cancers12092351 · Cited by 56 · see citing works
Analytical methods in studying cell force sensing: principles, current technologies and perspectives
Liu, X., Yu, L., Xiao, A., Sun, W., Wang, H., Wang, X., Zhou, Y., Li, C., Li, J., Wang, Y., et al. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf007 · Cited by 54 · see citing works
Regulation of Membrane Calcium Transport Proteins by the Surrounding Lipid Environment
Conrard, L., & Tyteca, D. (2019) · Biomolecules · doi:10.3390/biom9100513 · Cited by 52 · see citing works
pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology
Pethő, Z., Najder, K., Carvalho, T. M. A., McMorrow, R., Todesca, L. M., Rugi, M., Bulk, E., Chan, A. B., Löwik, C. W. G. M., Reshkin, S. J., et al. (2020) · Cancers · doi:10.3390/cancers12092484 · Cited by 51 · see citing works
Self-citation
Mechanosensitive Ion Channels and Their Role in Cancer Cells
Karska, J., Kowalski, S., Saczko, J., Moisescu, M. G., & Kulbacka, J. (2023) · Membranes · doi:10.3390/membranes13020167 · Cited by 47 · see citing works
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells
Kuntze, A., Ole, G., Fels, B., Najder, K., Unger, A., Wilhelmi, M., Sargin, S., Schimmelpfennig, S., Neumann, I., Schwab, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00089 · Cited by 46 · see citing works
Self-citation
Potassium channels: Novel targets for tumor diagnosis and chemoresistance
Li, M., Tian, P., Zhao, Q. X., Ma, X., & Zhang, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1074469 · Cited by 41 · see citing works
Cellular modulation by the mechanical cues from biomaterials for tissue engineering.
Wei, Q., Wang, S., Han, F., Wang, H., Zhang, W., Yu, Q., Liu, C., Ding, L., Wang, J., Yu, L., et al. (2021) · PubMed Central · doi:10.12336/biomatertransl.2021.04.001 · Cited by 41 · see citing works
Therapeutic potential of TRPM8 channels in cancer treatment
Ochoa, S. V., Casas, Z., Albarracín, S. L., Sutachan, J. J., & Torres, Y. P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1098448 · Cited by 43 · see citing works
Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
Wang, Y., Zhang, Z., Yang, Q., Cao, Y., Dong, Y., Bi, Y., & Liu, G. (2022) · Molecules · doi:10.3390/molecules28010213 · Cited by 37 · see citing works
Integrative research on the mechanisms of acupuncture mechanics and interdisciplinary innovation
Yunshan, L., Xu, C., Zhang, P., Haocheng, Q., Xudong, L., & Lu, L. (2025) · BioMedical Engineering OnLine · doi:10.1186/s12938-025-01357-w · Cited by 36 · see citing works
Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
Otero, Á., Blanco-Carlón, P., Navarro-Aguadero, M. Á., Gallardo, M., Martínez‐López, J., & Velasco‐Estevez, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813710 · Cited by 35 · see citing works
Alteration in cartilage matrix stiffness as an indicator and modulator of osteoarthritis
Song, J., Zeng, X., Li, C., Yin, H., Sui, M., & Ren, D. (2023) · Bioscience Reports · doi:10.1042/bsr20231730 · Cited by 33 · see citing works
Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca 2+ signals that are inhibited by oncogenic KRas
Pratt, S. J. P., Lee, R., Chang, K. T., Hernández‐Ochoa, E. O., Annis, D. A., Ory, E. C., Thompson, K. N., Bailey, P. C., Mathias, T. J., Ju, J. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009495117 · Cited by 33 · see citing works
The interplay between physical cues and mechanosensitive ion channels in cancer metastasis
Bera, K., Kiepas, A., Zhang, Y., Sun, S. X., & Κωνσταντόπουλος, Κ. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.954099 · Cited by 33 · see citing works
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review)
Wang, Z., Dong, S., & Zhou, W. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13233 · Cited by 32 · see citing works
The functions of mechanosensitive ion channels in tooth and bone tissues
Pei, F., Liu, J., Zhang, L., Pan, X., Huang, W., Cen, X. B., Huang, S., Jin, Y. H., & Zhao, Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109877 · Cited by 31 · see citing works
Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy
Hofschröer, V., Najder, K., Rugi, M., Bouazzi, R., Cozzolino, M., Arcangeli, A., Panyi, G., & Schwab, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.586599 · Cited by 31 · see citing works
Self-citation
Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and Malignancies
Momin, A., Bahrampour, S., Min, H.-K., Chen, X., Wang, X., Sun, Y., & Huang, X. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.02.006 · Cited by 29 · see citing works
Circulating tumor cells: mechanisms and clinical significance in colorectal cancer metastasis
Ren, X., Song, M. L., Liu, X., & He, W. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02465-w · Cited by 27 · see citing works
TRPV4 Overexpression Promotes Metastasis Through Epithelial–Mesenchymal Transition in Gastric Cancer and Correlates with Poor Prognosis
Wang, H., Zhang, B., Wang, X., Mao, J., Li, W., Sun, Y., Yuan, Y., Ben, Q., Li, H., & Qian, A. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s256918 · Cited by 26 · see citing works
Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels
Budde, I., Schlichting, A., Ing, D., Schimmelpfennig, S., Kuntze, A., Fels, B., Romac, J. M.-J., Swain, S. M., Liddle, R. A., Stevens, A., et al. (2025) · Journal of Cell Science · doi:10.1242/jcs.263846 · Cited by 27 · see citing works
Self-citation
Interaction of magnetic fields with biogenic magnetic nanoparticles on cell membranes: Physiological consequences for organisms in health and disease
Gorobets, O., Gorobets, S., Sharai, I., Polyakova, T., & Zablotskii, V. (2023) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2023.108390 · Cited by 25 · see citing works
Proton-Sensing G Protein-Coupled Receptors: Detectors of Tumor Acidosis and Candidate Drug Targets
Insel, P. A., Sriram, K., Salmerón, C., & Wiley, S. Z. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0357 · Cited by 24 · see citing works
Schistosome TRP channels: An appraisal
Bais, S., & Greenberg, R. M. (2020) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2020.02.002 · Cited by 24 · see citing works
Role of mechanosensitive channels/receptors in atherosclerosis
Mukherjee, P., Rahaman, S. G., Goswami, R., Dutta, B., Mahanty, M., & Rahaman, S. O. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00396.2021 · Cited by 24 · see citing works
An update regarding the role of WNK kinases in cancer
Xiu, M., Li, L., Li, Y., & Gao, Y. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05249-y · Cited by 25 · see citing works
Synthesis of Small‐Molecule Fluorescent Probes for the In Vitro Imaging of Calcium‐Activated Potassium Channel KCa3.1
Brömmel, K., Maskri, S., Maisuls, I., Konken, C. P., Rieke, M., Pethő, Z., Strassert, C. A., Koch, O., Schwab, A., & Wünsch, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001201 · Cited by 24 · see citing works
Self-citation
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model
Mikhailov, N., Plotnikova, L. M., Singh, P., Giniatullin, R. A., & Hämäläinen, R. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031370 · Cited by 23 · see citing works
Focusing on Mechanoregulation Axis in Fibrosis: Sensing, Transduction and Effecting
Wen, D., Gao, Y., Ho, C., Li, Y., Zhang, Y., Lyu, G., Hu, D., Li, Q., & Zhang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.804680 · Cited by 22 · see citing works
Effects of Electrical Stimulation on Stem Cells
Wang, H., Bhavsar, M. B., Han, Z., & Barker, J. H. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200129154747 · Cited by 20 · see citing works
Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues
Scarpellino, G., Munaron, L., Cantelmo, A. R., & Fiorio, A. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_32 · Cited by 20 · see citing works
Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.
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Authors: Pethő, Z., Najder, K., Bulk, E., & Schwab, A.
Affiliations: University of Münster (DE)
Corresponding author: Pethő, Zoltán
ORCID: Pethő, Zoltán
Najder, Karolina
Schwab, Albrecht
Venue: Cell Calcium
Publisher: Elsevier BV
Published: 2019-06
Volume: 80
Pages: 79-90
ISSN: 0143-4160 (ISSN-L)
DOI: 10.1016/j.ceca.2019.03.007
OpenAlex: W2927703930
Cited by: 125
References: 236
Citations by year: 2026: 8 · 2025: 22 · 2024: 19 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 21 · 2019: 5
FWCI: 1.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cell Calcium (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords: mechanosensitive ion channels, tumor progression, mechanotransduction, mechanosensing, calcium signaling, tumor microenvironment, tissue stiffness, shear stress, extracellular matrix remodeling, metastasis, Piezo channels, TRP channels, K2P channels, calcium-activated potassium channels, cell migration, stromal fibrosis
MeSH terms: Animals, Humans, Ion Channels, Neoplasms, Gene Expression Regulation, Neoplastic, Tumor Escape, Calcium Signaling, Mechanotransduction, Cellular, Tumor Microenvironment, Carcinogenesis

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Mechanosensitive ion channels push cancer progression

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