The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex
Open accessAbstract
Focused ultrasound (FUS) has recently been investigated as a new mode of non-invasive brain stimulation, which offers exquisite spatial resolution and depth control. We report on the elicitation of explicit somatosensory sensations as well as accompanying evoked electroencephalographic (EEG) potentials induced by FUS stimulation of the human somatosensory cortex. As guided by individual-specific neuroimage data, FUS was transcranially delivered to the hand somatosensory cortex among healthy volunteers. The sonication elicited transient tactile sensations on the hand area contralateral to the sonicated hemisphere, with anatomical specificity of up to a finger, while EEG recordings revealed the elicitation of sonication-specific evoked potentials. Retrospective numerical simulation of the acoustic propagation through the skull showed that a threshold of acoustic intensity may exist for successful cortical stimulation. The neurological and neuroradiological assessment before and after the sonication, along with strict safety considerations through the individual-specific estimation of effective acoustic intensity in situ and thermal effects, showed promising initial safety profile; however, equal/more rigorous precautionary procedures are advised for future studies. The transient and localized stimulation of the brain using image-guided transcranial FUS may serve as a novel tool for the non-invasive assessment and modification of region-specific brain function.
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Cites
Multimodality image registration by maximization of mutual information
Maes, F., Collignon, A., Vandermeulen, D., Marchal, G., & Suetens, P. (1997) · IEEE Transactions on Medical Imaging · doi:10.1109/42.563664 · Cited by 4,547
Deisseroth, K. (2011) · Nature Methods · doi:10.1038/nmeth.f.324 · Cited by 1,863
High-intensity focused ultrasound in the treatment of solid tumours
Kennedy, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1591 · Cited by 1,282
Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans
Legon, W., Sato, T. F., Opitz, A., Mueller, J., Barbour, A., Williams, A., & Tyler, W. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3620 · Cited by 981
Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
Tufail, Y., Matyushov, A., Baldwin, N., Tauchmann, M. L., Georges, J., Yoshihiro, A., Tillery, S. I. H., & Tyler, W. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.008 · Cited by 977
A Pilot Study of Focused Ultrasound Thalamotomy for Essential Tremor
Elias, W. J., Huss, D., Voss, T., Loomba, J., Khaled, M., Zadicario, E., Frysinger, R. C., Sperling, S. A., Wylie, S., Monteith, S. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300962 · Cited by 875
Noninvasive Human Brain Stimulation
Wagner, T., Valero-Cabre, A., & Pascual-Leone, A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.061206.133100 · Cited by 873
Fregni, F., & Pascual-Leone, A. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0530 · Cited by 823
Ultrasound–biophysics mechanisms
O’Brien, W. D. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.07.010 · Cited by 745
Focused ultrasound modulates region-specific brain activity
Yoo, S.-S., Bystritsky, A., Lee, J.-H., Zhang, Y., Fischer, K., Min, B.-K., McDannold, N. J., Pascual-Leone, A., & Jolesz, F. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.058 · Cited by 613
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Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications
Fomenko, A., Neudorfer, C., Dallapiazza, R. F., Kalia, S. K., & Lozano, A. M. (2018) · Brain Stimulation · doi:10.1016/j.brs.2018.08.013 · Cited by 322
Beisteiner, R., Matt, E., Fan, C., Baldysiak, H., Schönfeld, M., Philippi Novak, T., Amini, A., Aslan, T., Reinecke, R., Lehrner, J., et al. (2020) · Advanced Science · doi:10.1002/advs.201902583 · Cited by 269
Yang, T., Kim, J. R., Jin, H., Gil, H., Koo, J., & Kim, H. J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008831 · Cited by 178
Self-citationdi Biase, L., Falato, E., & Di Lazzaro, V. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00549 · Cited by 166
Nestor, P. J., Pelekanos, M., Leinenga, G., Song, J., Lee, W., Richter-Stretton, G., McElligott, C., Fazlollahi, A., Mattingley, J. B., Harris, A., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf445 · Cited by 3
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Metadata
- Authors
- Lee, W., Kim, H., Jung, Y., Song, I.-U., Chung, Y. A., & Yoo, S.-S.
- Venue
- Scientific Reports
- Published
- 2015-03-04
- Volume
- 5
- Issue
- 1
- Pages
- 8743-8743
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1979495791
- Cited by
- 414
- References
- 56
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- gold
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