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Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model
Open accessAbstract
The protein expressions of neurotrophic factors can be enhanced by low-intensity pulsed ultrasound (LIPUS) stimulation in the brain. The purpose of this study was to demonstrate the protective effect of LIPUS stimulation against aluminum-induced cerebral damage in Alzheimer's disease rat model. LIPUS was administered 7 days before each aluminum chloride (AlCl 3) administration and concomitantly given with AlCl 3 daily for a period of 6 weeks. Neurotrophic factors in hippocampus were measured by western blot analysis. Behavioral changes in the Morris water maze and elevated plus maze were examined in rats after administration of AlCl 3. Various biochemical analyses were performed to evaluate the extent of brain damages. LIPUS is capable of prompting levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF) in rat brain. AlCl 3 administration resulted in a significant increase in the aluminum concentration, acetylcholinesterase activity and beta-amyloid (Aβ) deposition in AlCl 3 treated rats. LIPUS stimulation significantly attenuated aluminum concentration, acetylcholinesterase activity, Aβ deposition and karyopyknosis in AlCl 3 treated rats. Furthermore, LIPUS significantly improved memory retention in AlCl 3-induced memory impairment. These experimental results indicate that LIPUS has neuroprotective effects against AlCl 3-induced cerebral damages and cognitive dysfunction.
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The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
Bailey, T. L., Rivara, C. B., Rocher, A. B., & Hof, P. R. (2004) · Neurological Research · doi:10.1179/016164104225016272 · Cited by 213
Cited by
A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications
Jiang, X., Savchenko, O., Li, Y., Qi, S., Yang, T., Zhang, W., & Chen, J. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2018.2889669 · Cited by 353
Beisteiner, R., Matt, E., Fan, C., Baldysiak, H., Schönfeld, M., Philippi Novak, T., Amini, A., Aslan, T., Reinecke, R., Lehrner, J., et al. (2020) · Advanced Science · doi:10.1002/advs.201902583 · Cited by 269
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102
Hatch, R. J., Leinenga, G., & Götz, J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0164278 · Cited by 34
Agrawal, M., Singhal, M., Semwal, B. C., Arora, S., Singh, B., Sikarwar, V., Sethi, P., Chaudhary, H., Akram, W., Bhargva, S., et al. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100492 · Cited by 28
Metadata
- Authors
- Lin, W.-T., Chen, R.-C., Lu, W.-W., Liu, S.-H., & Yang, F.-Y.
- Venue
- Scientific Reports
- Published
- 2015-04-15
- Volume
- 5
- Issue
- 1
- Pages
- 9671-9671
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1997382573
- Cited by
- 172
- References
- 1
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lin, W.-T., Chen, R.-C., Lu, W.-W., Liu, S.-H., & Yang, F.-Y. (2015). Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model. Scientific Reports. https://doi.org/10.1038/srep09671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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