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Cited by 521

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study

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Day, Felix R, Elks, Cathy E, Murray, Anna, Ong, Ken K, Perry, John R.B.·2015·Scientific Reports
DOI 10.1038/srep11208
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Abstract

Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women and therefore represents a potential target for early preventive interventions. We characterised the range of diseases and other adverse health outcomes associated with early or late puberty timing in men and women in the very large UK Biobank study. Recalled puberty timing and past/current diseases were self-reported by questionnaire. We limited analyses to individuals of White ethnicity (250,037 women; 197,714 men) and to disease outcomes with at least 500 cases (~0·2% prevalence) and we applied stringent correction for multiple testing (corrected threshold P < 7.48 × 10–5). In models adjusted for socioeconomic position and adiposity/body composition variables, both in women and men separately, earlier puberty timing was associated with higher risks for angina, hypertension and T2D. Furthermore, compared to the median/average group, earlier or later puberty timing in women or men was associated with higher risks for 48 adverse outcomes, across a range of cancers, cardio-metabolic, gynaecological/obstetric, gastrointestinal, musculoskeletal and neuro-cognitive categories. Notably, both early and late menarche were associated with higher risks for early natural menopause in women. Puberty timing in both men and women appears to have a profound impact on later health.

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Research works printed but not linked: 21

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  2. Harrington, J. & Palmert, M. R. Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. The Journal of clinical endocrinology and metabolism 97, 3056–3067, doi:10.1210/jc.2012-1598 (2012). · DOI · Paper page
  3. Prentice, P. & Viner, R. M. Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis. International journal of obesity 37, 1036–1043, doi:10.1038/ijo.2012.177 (2013). · DOI · Paper page
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  5. Charalampopoulos, D., McLoughlin, A. M., Elks, C. E. & Ong, K. K. Age at menarche and risks of all-cause and cardiovascular mortality: a systematic review and meta-analysis. American journal of epidemiology 180, 29–40 (2014). · DOI · Paper page
  6. Forman, M. R., Mangini, L. D., Thelus-Jean, R. & Hayward, M. D. Life-course origins of the ages at menarche and menopause. Adolescent health, medicine and therapeutics 4, 1–21, doi:10.2147/AHMT.S15946 (2013). · DOI
  7. Ong, K. K. et al. Timing of voice breaking in males associated with growth and weight gain across the life course. J Clin Endocrinol Metab 97, 2844–2852, doi:10.1210/jc.2011-3445 (2012). · DOI
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  14. Cooper, R. et al. Validity of age at menarche self-reported in adulthood. Journal of epidemiology and community health 60, 993–997 (2006). · DOI
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Cited by

Metadata

Authors
Day, F. R., Elks, C. E., Murray, A., Ong, K. K., & Perry, J. R. B.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2015-06-18
Volume
5
Issue
1
Pages
11208-11208
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep11208
OpenAlex
W1594932835
Cited by
521
References
7
FWCI
38.66
Type
journal article
Language
en
Open access
gold
Licence

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