Cited by 435Child Abuse and TraumaStress Responses and CortisolChild and Adolescent Psychosocial and Emotional Development

Biological aging in childhood and adolescence following experiences of threat and deprivation: a systematic review and meta-analysis

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Colich, Natalie L., Rosen, Maya L., Williams, Eileen S., McLaughlin, Katie A.·2020·Psychological Bulletin

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Abstract

= -0.43), but deprivation and SES were unrelated to accelerated development. Systematic review revealed associations between ELA and accelerated cortical thinning, with threat-related ELA consistently associated with thinning in ventromedial prefrontal cortex, and deprivation and SES associated with thinning in frontoparietal, default, and visual networks. There was no consistent association of ELA with amygdala-PFC connectivity. These findings suggest specificity in the types of early environmental experiences associated with accelerated biological aging and highlight the importance of evaluating how accelerated aging contributes to health disparities and whether this process can be mitigated through early intervention. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

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Authors
Colich, N. L., Rosen, M. L., Williams, E. S., & McLaughlin, K. A.
Affiliations
  • University of Washington (US)
  • Harvard University (US)
  • Stanford University (US)
Corresponding author
Colich, Natalie L.
Venue
Psychological Bulletin
Published
2020-09
Volume
146
Issue
9
Pages
721-764
ISSN
  • 0033-2909 (ISSN-L)
  • 1939-1455
OpenAlex
W3047379485
Cited by
433
References
315
Citations by year
2026: 67 · 2025: 66 · 2024: 65 · 2023: 84 · 2022: 83 · 2021: 49 · 2020: 15 · 2019: 1
FWCI
4.53
Type
journal article
Language
en
Open access
Locations
  • Psychological Bulletin (publishedVersion, other-oa)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Smith ScholarWorks (Smith College) (submittedVersion)
  • OSF Preprints (OSF Preprints) (submittedVersion)
Funders
National Institutes of Health (F32-MH114317, F32-HD089514; K99-HD099203, R01-MH103291; R01-MH106482; R56-MH119194; R37-MH119194)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
biological aging, childhood adversity, deprivation, socioeconomic status, accelerated development, cortical thinning, ventromedial prefrontal cortex, default mode network, health disparities, early intervention
MeSH terms
Adverse Childhood Experiences, Food Insecurity, Adolescent, Aging, Brain, Child, Child Abuse, Humans, Psychosocial Deprivation, Puberty, Social Class, Violence, Biomarkers, Cellular Senescence, DNA Methylation, Aging, Premature

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