ZnuA and zinc homeostasis in Pseudomonas aeruginosa
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Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P. aeruginosa to colonise both environmental and host niches is the acquisition of zinc. Here we show that P. aeruginosa PAO1 acquires zinc via an ATP-binding cassette (ABC) permease in which ZnuA is the high affinity, zinc-specific binding protein. Zinc uptake in Gram-negative organisms predominantly occurs via an ABC permease, and consistent with this expectation a P. aeruginosa ΔznuA mutant strain showed an ~60% reduction in cellular zinc accumulation, while other metal ions were essentially unaffected. Despite the major reduction in zinc accumulation, minimal phenotypic differences were observed between the wild-type and ΔznuA mutant strains. However, the effect of zinc limitation on the transcriptome of P. aeruginosa PAO1 revealed significant changes in gene expression that enable adaptation to low-zinc conditions. Genes significantly up-regulated included non-zinc-requiring paralogs of zinc-dependent proteins and a number of novel import pathways associated with zinc acquisition. Collectively, this study provides new insight into the acquisition of zinc by P. aeruginosa PAO1, revealing a hitherto unrecognized complexity in zinc homeostasis that enables the bacterium to survive under zinc limitation.
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Pseudomonas aeruginosa expresses a ZnuABC zinc transporter under zinc-deplete conditions.
“Pseudomonas aeruginosa, a soil bacterium that commonly colonizes the respiratory tract of cystic fibrosis patients, also expresses a ZnuABC zinc transporter under zinc-deplete conditions (Pederick et al., 2015).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Pederick et al., 2015
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- Authors
- Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C., & McDevitt, C. A.
- Affiliations
- The University of Adelaide (AU)
- Corresponding author
- McDevitt, Christopher A.
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-08-20
- Volume
- 5
- Issue
- 1
- Pages
- 13139-13139
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4542158
- OpenAlex
- W1144832332
- Cited by
- 138
- References
- 66
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 24 · 2020: 9 · 2019: 18 · 2018: 11 · 2017: 12 · 2016: 5 · 2015: 1
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Medical Research Council
- Australian Research Council (DP120103957)
- National Health and Medical Research Council (565526, 1071659, 1080784, 1022240)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Pseudomonas aeruginosa PAO1, zinc homeostasis, zinc uptake, zinc limitation, transcriptome, gene expression adaptation
- MeSH terms
- Amino Acid Sequence, Bacterial Proteins, Homeostasis, Models, Biological, Molecular Sequence Data, Pseudomonas aeruginosa, Ribosomal Proteins, Substrate Specificity, Transcription, Genetic, Zinc, Down-Regulation, Up-Regulation, Gene Expression Regulation, Bacterial, Sequence Homology, Amino Acid, Computational Biology, Amino Acid Motifs, Membrane Transport Proteins, Transition Temperature
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