ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy
Open accessAbstract
Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of human breast cancer cells including estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) positive and triple negative breast cancer (TNBC) cells after treatment with PpIX precursor aminolevulinic acid (ALA). Although PpIX fluorescence was heterogeneous in different cells, TNBC cells showed significantly lower PpIX level than MCF10A and ER- or HER2-positive cells. PpIX fluorescence in TNBC cells also had much less mitochondrial localization than other cells. There was an inverse correlation between PpIX fluorescence and cell viability after PDT. Breast cancer cells with the highest PpIX fluorescence were the most sensitive to ALA-PDT and TNBC cells with the lowest PpIX level were resistant to PDT. Treatment of TNBC cells with ABCG2 transporter inhibitor Ko143 significantly increased ALA-PpIX fluorescence, enhanced PpIX mitochondrial accumulation and sensitized cancer cells to ALA-PDT. Ko143 treatment had little effect on PpIX production and ALA-PDT in normal and ER- or HER2-positive cells. These results demonstrate that enhanced ABCG2 activity renders TNBC cell resistance to ALA-PDT and inhibiting ABCG2 transporter is a promising approach for targeting TNBC with ALA-based modality.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ko143 treatment also preferentially induces PpIX accumulation in mitochondria after ALA, sensitizing tumor cells to PDT-induced apoptosis.
“In addition to the increase in total PpIX fluorescence, Ko143 treatment also preferentially induces PpIX accumulation in mitochondria after ALA, therefore, sensitizing tumor cells to PDT-induced apoptosis [123,125,128].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [125]
The Results report that Ko143 increased mitochondrial PpIX localization after ALA and sensitized two triple-negative breast cancer cell lines to ALA-PDT. The Discussion links the increased mitochondrial accumulation to that sensitization. The paper reports reduced cell survival, however, not PDT-induced apoptosis specifically. (LLM, conf=0.88)
Experimental — accuracy not yet measuredKo143 is able to significantly enhance ALA-PpIX fluorescence in different human tumor cell lines including skin, bladder, breast, kidney, and brain tumors.
“Ko143 is able to significantly enhance ALA-PpIX fluorescence in different human tumor cell lines including skin, bladder, breast, kidney, and brain tumors [122,123,124,125,126,127].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [125]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21254 · Cited by 11,854 · see citing works
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145 · see citing works
Stummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423 · see citing works
Jonker, J. W., Buitelaar, M., Wagenaar, E., van der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plösch, T., Kuipers, F., Elferink, R. P. J. O., Rosing, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202607599 · Cited by 822 · see citing works
Allen, J. D., van Loevezijn, A., Rademaker-Lakhai, J. M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J. H. M., Koomen, G., & Schinkel, A. H. (2002) · PubMed · Cited by 690 · see citing works
Ponka, P. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199910000-00004 · Cited by 652 · see citing works
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
Natarajan, K., Xie, Y., Baer, M. R., & Ross, D. D. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.002 · Cited by 408 · see citing works
Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition
Robey, R. W., Steadman, K., Polgár, O., Morisaki, K., Blayney, M., Mistry, P., & Bates, S. E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3298 · Cited by 350 · see citing works
Molecular and Cellular Heterogeneity in Breast Cancer
Rivenbark, A. G., O’Connor, S., & Coleman, W. B. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.08.002 · Cited by 327 · see citing works
ABCG2-mediated transport of photosensitizers: Potential impact on photodynamic therapy
Robey, R. W., Steadman, K., Polgar, O., & Bates, S. E. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1440 · Cited by 204 · see citing works
Triple-Negative Breast Cancer and the Need for New Therapeutic Targets
Engebraaten, O., Vollan, H. K. M., & Børresen‐Dale, A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.033 · Cited by 178 · see citing works
Genetic and Phenotypic Diversity in Breast Tumor Metastases
Almendro, V., Kim, H. J., Cheng, Y.-K., Gönen, M., Itzkovitz, S., Argani, P., van Oudenaarden, A., Sukumar, S. V., Franziska Michor, A., & Polyák, K. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2357-t · Cited by 174 · see citing works
Biomodulatory approaches to photodynamic therapy for solid tumors
Anand, S., Ortel, B. J., Pereira, S. P., Hasan, T. G., & Maytin, E. V. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.07.026 · Cited by 162 · see citing works
Kobuchi, H., Moriya, K., Ogino, T., Fujita, H., Inoue, K., Shuin, T., Yasuda, T., Utsumi, K., & Utsumi, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050082 · Cited by 137 · see citing works
Liu, W., Baer, M. R., Bowman, M. J., Pera, P., Zheng, X., Morgan, J., Pandey, R. A., & Oseroff, A. R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1599 · Cited by 136 · see citing works
Breast cancer, side population cells and ABCG2 expression
Britton, K. M., Eyre, R., Harvey, I. J., Stemke‐Hale, K., Browell, D., Lennard, T. W. J., & Meeson, A. P. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.03.041 · Cited by 126 · see citing works
Ji, Z., Yang, G., Vasovič, V., Čunderlı́ková, B., Suo, Z., Nesland, J. M., & Peng, Q. (2006) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2006.03.006 · Cited by 126 · see citing works
Silencing of human ferrochelatase causes abundant protoporphyrin‐IX accumulation in colon cancer
Kemmner, W., Wan, K., Rüttinger, S., Ebert, B., Macdonald, R., Klamm, U., & Moesta, K. T. (2008) · The FASEB Journal · doi:10.1096/fj.07-8888com · Cited by 114 · see citing works
Bryostatin-I—An Antineoplastic Treasure from the Deep?
May, W. S., & Ruvolo, P. P. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.4.20 · Cited by 88 · see citing works
Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications
Nokes, B. T., Apel, M., Jones, C., Brown, G. E., & Lang, J. E. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.02.002 · Cited by 86 · see citing works
Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid
Ladner, D. P., Steiner, R. A., Allemann, J., Haller, U., & Walt, H. K. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1532 · Cited by 69 · see citing works
Kanick, S. C., Davis, S. C., Zhao, Y. Q., Hasan, T. G., Maytin, E. V., Pogue, B. W., & Chapman, M. S. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.7.075002 · Cited by 60 · see citing works
Yang, X., Li, W., Palasuberniam, P., Myers, K. A., Wang, C., & Chen, B. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12454 · Cited by 55 · see citing works
Self-citationMillon, S. R., Ostrander, J. H., Yazdanfar, S., Brown, J. Q., Bender, J. E., Rajeha, A., & Ramanujam, N. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3302811 · Cited by 49 · see citing works
Differential Sensitivity in Cell Lines to Photodynamic Therapy in Combination with ABCG2 Inhibition
Barron, G. A., Moseley, H., & Woods, J. A. (2013) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2013.07.003 · Cited by 40 · see citing works
Frei, K. A., Bonél, H., Frick, H., Walt, H. K., & Steiner, R. A. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601615 · Cited by 40 · see citing works
Yoon, J. H., Yoon, H., Kim, O., Kim, S. K., Ahn, S., & Kang, K. W. (2012) · Lasers in Surgery and Medicine · doi:10.1002/lsm.21154 · Cited by 37 · see citing works
Vitamin D enhances the efficacy of photodynamic therapy in a murine model of breast cancer
Rollakanti, K. R., Anand, S., & Maytin, E. V. (2015) · Cancer Medicine · doi:10.1002/cam4.361 · Cited by 36 · see citing works
Specific Inhibition of the ABCG2 Transporter Could Improve the Efficacy of Photodynamic Therapy
Bebes, A., Nagy, T., Bata-Csörgő, Z., Kemény, L., Dobozy, A., & Széll, M. (2011) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2011.08.007 · Cited by 28 · see citing works
Fisher, C., Niu, C. J., Lai, B., Chen, Y., Kuta, V., & Lilge, L. D. (2013) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22161 · Cited by 21 · see citing works
Dorward, A. M., Fancher, K. S., Duffy, T. M., Beamer, W. G., & Walt, H. K. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602840 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
5‐ALA in the management of malignant glioma
Stepp, H., & Stummer, W. (2018) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22933 · Cited by 234 · see citing works
Belykh, E. G., Shaffer, K. V., Lin, C., Byvaltsev, V. A., Preul, M. C., & Chen, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00739 · Cited by 196 · see citing works
Yang, X., Palasuberniam, P., Kraus, D., & Chen, B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025865 · Cited by 158 · see citing works
Self-citationMiyata, H., Takada, T., Toyoda, Y., Matsuo, H., Ichida, K., & Suzuki, H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00518 · Cited by 146 · see citing works
The Multifaceted Role of Heme in Cancer
Fiorito, V., Chiabrando, D., Petrillo, S., Bertino, F., & Tolosano, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01540 · Cited by 129 · see citing works
Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers
Wang, X.-N., Luo, D., & Basilion, J. (2021) · Cancers · doi:10.3390/cancers13122992 · Cited by 108 · see citing works
Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression
Sha, S., Yuan, D., Liu, Y., Han, B., Zhong, N., & Liu, Z. (2017) · Biology Open · doi:10.1242/bio.023135 · Cited by 108 · see citing works
Orlando, U. D., Castillo, A. F., Medrano, M. A. R., Solano, A. R., Maloberti, P. M., & Podesta, E. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.005 · Cited by 96 · see citing works
McNicholas, K., MacGregor, M., & Gleadle, J. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0516-4 · Cited by 83 · see citing works
Tumor associated macrophages and ‘NO’
Nath, N., & Kashfi, K. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113899 · Cited by 66 · see citing works
Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy
Cho, H., Lee, T., Yoon, J., Han, Z., Rabie, H., Lee, K., Su, W., & Choi, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19255 · Cited by 59 · see citing works
Wang, W., Tabu, K., Hagiya, Y., Sugiyama, Y., Kokubu, Y., Murota, Y., Ogura, S., & Taga, T. (2017) · Scientific Reports · doi:10.1038/srep42070 · Cited by 59 · see citing works
Kitajima, Y., Ishii, T., Kohda, T., Ishizuka, M., Yamazaki, K., Nishimura, Y., Tanaka, T., Dan, S., & Nakajima, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44981-y · Cited by 56 · see citing works
ABCG2 influence on the efficiency of photodynamic therapy in glioblastoma cells
Müller, P., Abdel Gaber, S. A., Zimmermann, W., Wittig, R., & Stepp, H. (2020) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2020.111963 · Cited by 49 · see citing works
Cancer Cell‐Specific Fluorescent Prodrug Delivery Platforms
Ma, S.-Y., Kim, J. H., Chen, W., Li, L., Lee, J., Xue, J., Liu, Y., Chen, G., Tang, B., Tao, W., et al. (2023) · Advancement of science · doi:10.1002/advs.202207768 · Cited by 36 · see citing works
Kawai, N., Hirohashi, Y., Ebihara, Y., Saito, T., Murai, A., Saito, T., Shirosaki, T., Kubo, T., Nakatsugawa, M., Kanaseki, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216503 · Cited by 43 · see citing works
Gao, F., Zheng, W., Gao, L., Cai, P., Liu, R., Wang, Y., Yuan, Q., Zhao, Y., & Gao, X. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601453 · Cited by 42 · see citing works
Mansi, M., Howley, R., Chandratre, S., & Chen, B. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115031 · Cited by 38 · see citing works
Self-citationCRISPR/Cas9 as a therapeutic tool for triple negative breast cancer: from bench to clinics
Tiwari, P. K., Ko, T.-H., Dubey, R., Chouhan, M., Tsai, L.-W., Singh, H. N., Chaubey, K. K., Dayal, D., Chiang, C., & Kumar, S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1214489 · Cited by 41 · see citing works
Enhancing 5-ALA-PDT efficacy against resistant tumor cells: Strategies and advances
Ebrahimi, S., Ghadiri, M. K., Stummer, W., & Gorji, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122808 · Cited by 36 · see citing works
Khot, M. I., Perry, S., Maisey, T. I., Armstrong, G., Andrew, H., Hughes, T. A., Kapur, N., & Jayne, D. G. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.06.027 · Cited by 36 · see citing works
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Breast Cancer Research · doi:10.1186/s13058-021-01442-7 · Cited by 36 · see citing works
Jendželovský, R., Jendželovská, Z., Kuchárová, B., & Fedoročko, P. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.084 · Cited by 35 · see citing works
5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
Howley, R., Chandratre, S., & Chen, B. (2023) · Bioengineering · doi:10.3390/bioengineering10040496 · Cited by 33 · see citing works
Self-citationChandratre, S., Olsen, J., Howley, R., & Chen, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115851 · Cited by 30 · see citing works
Self-citationThe role of microRNAs in photodynamic therapy of cancer
El‐Daly, S. M., Abba, M. L., & Gamal‐Eldeen, A. M. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.011 · Cited by 30 · see citing works
Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell lines
Herceg, V., Lange, N., Allémann, É., & Babič, A. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.04.029 · Cited by 27 · see citing works
Cai, J., Zheng, Q., Huang, H., & Li, B. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.01.004 · Cited by 27 · see citing works
Upregulation of pro-tumor nitric oxide by anti-tumor photodynamic therapy
Girotti, A. W., & Fahey, J. M. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113750 · Cited by 26 · see citing works
Howley, R., Mansi, M., Shinde, J., Restrepo, J., & Chen, B. (2020) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2020.112017 · Cited by 25 · see citing works
Self-citationBystander Effects of Nitric Oxide in Cellular Models of Anti-Tumor Photodynamic Therapy
Bazak, J., Korytowski, W., & Girotti, A. W. (2019) · Cancers · doi:10.3390/cancers11111674 · Cited by 25 · see citing works
Králová, J., Kolář, M., Kahle, M., Truksa, J., Lettlová, S., Balušíková, K., & Bartůněk, P. (2017) · Scientific Reports · doi:10.1038/srep44497 · Cited by 24 · see citing works
Palasuberniam, P., Kraus, D., Mansi, M., Braun, A., Howley, R., Myers, K. A., & Chen, B. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13091 · Cited by 23 · see citing works
Self-citationSzewczyk, G. M., Mokrzynski, K. T., & Sarna, T. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-024-00620-8 · Cited by 22 · see citing works
The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy
Khot, M. I., Downey, C. L., Armstrong, G., Svavarsdottir, H. S., Jarral, F., Andrew, H., & Jayne, D. G. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.10.014 · Cited by 22 · see citing works
Mastrangelopoulou, M., Grigalavicius, M., Raabe, T. T. H., Skarpen, E., Juzenas, P., Peng, Q., Berg, K., & Theodossiou, T. A. (2020) · Cancer Reports · doi:10.1002/cnr2.1278 · Cited by 21 · see citing works
Liang, B. J., Lusvarghi, S., Ambudkar, S. V., & Huang, H. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00138 · Cited by 21 · see citing works
Joniová, J., Kazemiraad, C., Gerelli, E., & Wagnières, G. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112347 · Cited by 21 · see citing works
León, D., Buchegger, K., Silva, R., Riquelme, I., Viscarra, T., Mora‐Lagos, B., Zanella, L., Schafer, F., Kurachi, C., Roa, J. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093327 · Cited by 19 · see citing works
Girotti, A. W., Fahey, J. F., & Korytowski, W. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103805 · Cited by 18 · see citing works
Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid
Morita, M., Tanaka, H., Kumamoto, Y., Nakamura, A., Harada, Y., Ogata, T., Sakaguchi, K., Taguchi, T., & Takamatsu, T. (2019) · Cancer Medicine · doi:10.1002/cam4.2466 · Cited by 18 · see citing works
Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy
Chelakkot, V. S., Som, J., Yoshioka, E., Rice, C. P. J., Rutihinda, S. G., & Hirasawa, K. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0586-3 · Cited by 19 · see citing works
Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
Lou, L., Zhou, S., Tan, S., Xiang, M., Wang, W., Yuan, C., Gao, L., & Xiao, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1137707 · Cited by 19 · see citing works
Yang, X., Palasuberniam, P., Myers, K. A., Wang, C., & Chen, B. (2016) · Oncotarget · doi:10.18632/oncotarget.11058 · Cited by 18 · see citing works
Self-citationNitric Oxide‐Mediated Resistance to Antitumor Photodynamic Therapy
Girotti, A. W. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13163 · Cited by 18 · see citing works
Majerník, M., Jendželovský, R., Vargová, J., Jendželovská, Z., & Fedoročko, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051075 · Cited by 17 · see citing works
Girotti, A. W., Fahey, J. M., & Korbelik, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050593 · Cited by 16 · see citing works
Hashemkhani, M., Celikbas, E., Khan, M., Sennaroğlu, A., & Acar, H. Y. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00105 · Cited by 16 · see citing works
Molecular pathways in cancer response to photodynamic therapy
Rapozzi, V., D’Este, F., & Xodo, L. E. (2019) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424619300064 · Cited by 16 · see citing works
Webb, B. M., Bryson, B. L., Williams-Medina, E., Bobbitt, J. R., Seachrist, D. D., Anstine, L. J., & Keri, R. A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101162 · Cited by 16 · see citing works
Palasuberniam, P., Kraus, D., Mansi, M. S., Howley, R., Braun, A., Myers, K. A., & Chen, B. (2021) · Journal of Biomedical Optics · doi:10.1117/1.jbo.26.9.098002 · Cited by 16 · see citing works
Self-citationYamamoto, S., Fukuhara, H., Seki, H., Kawada, C., Nakayama, T., Karashima, T., Ogura, S., & Inoue, K. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102452 · Cited by 15 · see citing works
Girotti, A. W., & Korytowski, W. (2020) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-020-00909-2 · Cited by 14 · see citing works
Postiglione, I., Barra, F., Aloj, S. M., & Palumbo, G. A. (2016) · Cell Proliferation · doi:10.1111/cpr.12274 · Cited by 13 · see citing works
Howley, R., Olsen, J., & Chen, B. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13936 · Cited by 11 · see citing works
Self-citationSchary, N., Novak, B., Kämper, L., Yousf, A., & Lübbert, H. (2022) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2022.103004 · Cited by 9 · see citing works
Chandratre, S., Merenich, D., Myers, K., & Chen, B. (2024) · APOPTOSIS · doi:10.1007/s10495-024-02012-w · Cited by 8 · see citing works
Self-citationAi, J., Li, J., Ga, L., Yun, G., Xu, L., & Wang, E. (2016) · RSC Advances · doi:10.1039/c6ra18178c · Cited by 8 · see citing works
Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer
Consoli, V., Sorrenti, V., Gulisano, M., Spampinato, M., & Vanella, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05119-5 · Cited by 7 · see citing works
Kars, M. D., Yıldırım, G., Gündoğdu, Y., Gönce, F., Ayan, E. B., & Kılıç, H. Ş. (2020) · The EuroBiotech Journal · doi:10.2478/ebtj-2020-0024 · Cited by 7 · see citing works
Girotti, A. W., Bazak, J., & Korytowski, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411559 · Cited by 9 · see citing works
Liu, Y., Mensah, S. K., Farias, S., Khan, S., Hasan, T. G., & Celli, J. P. (2024) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2024.104362 · Cited by 6 · see citing works
Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line
Fontana, L. C., Pinto, J. G., Vitorio, G. D. S., Ferreira, I., Soares, C. P., Mamone, L. A., & Ferreira–Strixino, J. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102669 · Cited by 6 · see citing works
Mansi, M., Howley, R., & Chen, B. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1811-0_43 · Cited by 6 · see citing works
Self-citationGibson, C., Wang, S. C., Phoon, A., Anantha, N. T., Ottolino‐Perry, K., Petropoulos, S., Qureshi, Z., Subramanian, V., Shahid, A., O’Brien, C., et al. (2024) · BMC Biomedical Engineering · doi:10.1186/s42490-024-00079-9 · Cited by 5 · see citing works
Negative effects of tumor cell nitric oxide on anti-glioblastoma photodynamic therapy
Girotti, A. W., Fahey, J. M., & Korytowski, W. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.107 · Cited by 5 · see citing works
Ashraf, S., Khalid, A., Kuriakose, J., Palanisami, A., Feng, Y., & Hasan, T. G. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112286 · Cited by 5 · see citing works
de Andrade, L. R., Tedesco, A. C., Primo, F. L., Farias, G. R., Silva, D., Longo, J. P. F., de Almeida, M. C., de Souza, P. E., Azevedo, R. B., Pinheiro, W. O., et al. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0458 · Cited by 5 · see citing works
Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro
Vig, S., Srivastava, P., Rahman, I., Jaranson, R., Dasgupta, A., Perttilä, R., Uusimaa, P., & Huang, H. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.50 · Cited by 4 · see citing works
Pro-tumor Bystander Effects of Nitric Oxide in Anti-tumor Photodynamic TherapyPreprint
Girotti, A. W., Bazak, J., & Korytowski, W. (2023) · Preprints.org · doi:10.20944/preprints202304.0819.v1 · Cited by 4 · see citing works
Chu, E. S. M., Wu, R. W. K., & Huang, Z. W. (2024) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2024.103998 · Cited by 3 · see citing works
Kumbham, S., Rahman, K. M. M., Bosmajian, C., Bist, G., Foster, B. A., Woo, S., & You, Y. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13982 · Cited by 3 · see citing works
Olsen, J., Chandratre, S., Alsalamah, L., Merenich, D., Myers, K. A., & Chen, B. (2025) · Photochemistry and Photobiology · doi:10.1111/php.70057 · Cited by 2 · see citing works
Self-citationChandratre, S., Olsen, J., & Chen, B. (2025) · Photochemistry and Photobiology · doi:10.1111/php.14077 · Cited by 1 · see citing works
Self-citationAbdurashitov, A. S., Proshin, P. I., Sain, A. Y., Terentyeva, D. A., Kosov, A. D., Sukhorukov, G. B., & Sindeeva, O. A. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113372 · Cited by 1 · see citing works
Pustimbara, A., Umami, R. W., Prakoso, N. M., Rozaliyani, A., Zaini, J., Dwiranti, A., Ogura, S., & Bowolaksono, A. (2024) · Medical Sciences · doi:10.3390/medsci12040066 · Cited by 1 · see citing works
Targeting the Genetic and Molecular Role of ABCG2 Following Traumatic Brain Injury
Adams, S. M. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
Benefits and Problems of Photodynamic Diagnosis in Brain Tumor Treatment
Nitta, M., & Muragaki, Y. (2020) · Nippon Laser Igakkaishi · doi:10.2530/jslsm.jslsm-41_0036
Soliman, S. A., Rashed, L. A., Said, M. M., & Medhat, A. M. (2019) · Journal of cancer research updates · doi:10.30683/1929-2279.2019.08.04
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966321
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966342
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966333
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966339
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966324
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966345
Ottolino‐Perry, K., Shahid, A., DeLuca, S., Son, V., Sukhram, M., Meng, F., Liu, Z. (. A., Rapic, S., Anantha, N. T., Wang, S. C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966330
Targeting the Heme biosynthesis pathway: strategies to enhance 5-ALA-mediated photodynamic therapy
Ren, J., Li, Y., Fu, J., Zhou, R., Zhang, C., & Xie, Y. (2026) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2026.130739
Beyond chemotherapy: the evolving role of photodynamic therapy in triple-negative breast cancer
Rashwan, H. H., & Azzazy, H. M. E. (2026) · Medical Oncology · doi:10.1007/s12032-026-03326-2
Effects of ABCG2 knockdown on therapeutic enhancement of 5‐aminolevulinic acid with lapatinib
Wescoat, J., Cabral, C., & Chen, B. (2026) · Photochemistry and Photobiology · doi:10.1111/php.70157
Self-citation
- Authors
- Palasuberniam, P., Yang, X., Kraus, D., Jones, P., Myers, K. A., & Chen, B.
- Affiliations
- University of the Sciences (US)
- Corresponding author
- Chen, Bin
- Venue
- Scientific Reports
- Published
- 2015-08-18
- Volume
- 5
- Issue
- 1
- Pages
- 13298-13298
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4539603
- OpenAlex
- W2419531088
- Cited by
- 89
- References
- 31
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 17 · 2020: 12 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 1
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- American Cancer Society (RSG-10-035-01-CCE)
- National Heart, Lung, and Blood Institute (K22HL113069)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- ABCG2, Ko143, 5-aminolevulinic acid, photodynamic therapy, protoporphyrin IX, triple-negative breast cancer, photosensitizer accumulation, mitochondrial localization, drug resistance, ABCG2 inhibitors, breast cancer cell lines
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2, Adenosine, Cell Survival, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Drug Synergism, Heterocyclic Compounds, 4 or More Rings, Humans, Light, Malonates, Neoplasm Proteins, Photochemotherapy, Radiation Tolerance, Treatment Outcome, Photosensitizing Agents, ATP-Binding Cassette Transporters, Cell Line, Tumor, Diketopiperazines, Triple Negative Breast Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
