Local bacteria affect the efficacy of chemotherapeutic drugs
Open accessAbstract
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was replicated in in vivo murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Of a panel of 30 chemotherapeutic drugs examined in vitro against various bacteria, 10 were inhibited and six exhibited improved efficacy linked to modification of the chemical structure of the drug for gemcitabine, fludarabine, cladribine, and CB1954.
“of a panel of 30 chemotherapeutic drugs examined in vitro against various bacteria, 10 were found to be inhibited and six exhibited improved efficacy in a way that could be linked to modification of the chemical structure of the drug in the case of gemcitabine, fludarabine, cladribine, and CB1954 (Lehouritis et al., 2015).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Lehouritis et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science · doi:10.1126/science.1240537 · Cited by 2,050 · see citing works
The gastrointestinal microbiota as a site for the biotransformation of drugs
Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.009 · Cited by 618 · see citing works
Combination bacteriolytic therapy for the treatment of experimental tumors
Dang, L. H., Bettegowda, C., Huso, D. L., Kinzler, K. W., & Vogelstein, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251543698 · Cited by 565 · see citing works
Microbiota of Human Breast Tissue
Urbaniak, C., Cummins, J., Brackstone, M., Macklaim, J. M., Gloor, G. B., Baban, C. K., Scott, L., O'Hanlon, D. M., Burton, J. P., Francis, K. P., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00242-14 · Cited by 552 · see citing works
Microbial Dysbiosis Is Associated with Human Breast Cancer
Xuan, C., Shamonki, J. M., Chung, A., DiNome, M. L., Chung, M., Sieling, P. A., & Lee, D. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083744 · Cited by 543 · see citing works
Fusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works
Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., et al. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2081-3 · Cited by 498 · see citing works
Colonization of the Human Gut by <i>E. coli</i> and Colorectal Cancer Risk
Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works
Intratumoral injection of <i>Clostridium novyi</i> -NT spores induces antitumor responses
Roberts, N. J., Zhang, L., Janku, F., Collins, A., Bai, R.-Y., Staedtke, V., Rusk, A. W., Tung, D., Miller, M., Roix, J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008982 · Cited by 400 · see citing works
Leist, T. P., Comi, G., Cree, B., Coyle, P. K., Freedman, M. S., Hartung, H.-P., Vermersch, P., Casset‐Semanaz, F., & Scaramozza, M. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70005-5 · Cited by 251 · see citing works
Pierantozzi, M., Pietroiusti, A., Brusa, L., Galati, S., Stefani, A., Lunardi, G., Fedele, E., Sancesario, G., Bernardi, G., Bergamaschi, A., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000221672.01272.ba · Cited by 199 · see citing works
Developing a metagenomic view of xenobiotic metabolism
Haiser, H. J., & Turnbaugh, P. J. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.07.009 · Cited by 186 · see citing works
Bacteria and tumours: causative agents or opportunistic inhabitants?
Cummins, J., & Tangney, M. (2013) · Infectious Agents and Cancer · doi:10.1186/1750-9378-8-11 · Cited by 178 · see citing works
Pancreatic Cancer, Inflammation, and Microbiome
Zambirinis, C. P., Pushalkar, S., Saxena, D. B., & Miller, G. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000045 · Cited by 169 · see citing works
The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT
Bettegowda, C., Huang, X., Lin, J., Cheong, I., Kohli, M., Szabo, S. A., Zhang, X., Diaz, L. A., Velculescu, V. E., Parmigiani, G., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1256 · Cited by 163 · see citing works
Skinner, E. C., Goldman, B. H., Sakr, W., Petrylak, D. P., Lenz, H., Lee, C. T., Wilson, S., Benson, M. C., Lerner, S. P., Tangen, C. M., et al. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.04.031 · Cited by 161 · see citing works
High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
Cronin, M. A., Akin, A. R., Collins, S., Meganck, J., Kim, J., Baban, C. K., Joyce, S. A., van Dam, G. M., Zhang, N., van Sinderen, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030940 · Cited by 138 · see citing works
König, C. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.2.227 · Cited by 135 · see citing works
Is It Time for a Metagenomic Basis of Therapeutics?
Haiser, H. J., & Turnbaugh, P. J. (2012) · Science · doi:10.1126/science.1224396 · Cited by 133 · see citing works
Minton, N. P., Atkinson, T., & Sherwood, R. F. (1983) · Journal of Bacteriology · doi:10.1128/jb.156.3.1222-1227.1983 · Cited by 128 · see citing works
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123 · see citing works
Orally Administered Bifidobacteria as Vehicles for Delivery of Agents to Systemic Tumors
Cronin, M. A., Morrissey, D., Rajendran, S., Mashad, S. M. E., van Sinderen, D., O’Sullivan, G. C., & Tangney, M. (2010) · Molecular Therapy · doi:10.1038/mt.2010.59 · Cited by 117 · see citing works
New approaches to prevent intestinal toxicity of irinotecan-based regimens
Alimonti, A., Gelibter, A. J., Pavese, I., Satta, F., Cognetti, F., Ferretti, G., Rasio, D., Vecchione, A., & Palma, M. D. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.05.002 · Cited by 103 · see citing works
Bacterial Inactivation of the Anticancer Drug Doxorubicin
Westman, E. L., Canova, M. J., Radhi, I. J., Koteva, K. K., Kireeva, I., Waglechner, N., & Wright, G. D. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.08.011 · Cited by 102 · see citing works
Bloodstream Infections in Patients With Solid Tumors
Marín, M., Gudiol, C., García‐Vidal, C., Ardanuy, C., & Carratalà, J. (2014) · Medicine · doi:10.1097/md.0000000000000026 · Cited by 98 · see citing works
Older and new purine nucleoside analogs for patients with acute leukemias
Robak, P. J., & Robak, T. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.03.006 · Cited by 93 · see citing works
Helsby, N. A., Ferry, D. M., Patterson, A. V., Pullen, S. M., & Wilson, W. R. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601612 · Cited by 90 · see citing works
Tumour Targeting with Systemically Administered Bacteria
Morrissey, D., O’Sullivan, G. C., & Tangney, M. (2010) · Current Gene Therapy · doi:10.2174/156652310790945575 · Cited by 90 · see citing works
Jia, L., Wei, D., Sun, Q., Jin, G., Li, S., Huang, Y., & Hua, Z. (2007) · International Journal of Cancer · doi:10.1002/ijc.22688 · Cited by 65 · see citing works
The biodiversity of microbial cytochromes P450
Kelly, S. L., Lamb, D. C., Jackson, C. J., Warrilow, A. G. S., & Kelly, D. E. (2003) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(03)47003-3 · Cited by 63 · see citing works
Helicobacter pyloriinfection: New pathogenetic and clinical aspects
Hagymási, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i21.6386 · Cited by 63 · see citing works
Analysis of heterologous taxadiene production in K- and B-derived Escherichia coli
Boghigian, B. A., Salas, D., Ajikumar, P. K., Stephanopoulos, G. N., & Pfeifer, B. A. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3528-4 · Cited by 57 · see citing works
Houghton, B., Chalasani, V., Hayne, D., Grimison, P., Brown, C. S. B., Patel, M. I., Davis, I. D., & Stockler, M. R. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11390.x · Cited by 56 · see citing works
Enfermedades Infecciosas y Microbiología Clínica
Delgado, R. B. (2016) · Cited by 56 · see citing works
Listeria monocytogenes as a Vector for Anti-Cancer Therapies
Tangney, M., & Gahan, C. G. M. (2010) · Current Gene Therapy · doi:10.2174/156652310790945539 · Cited by 55 · see citing works
Tai, C.-M., Wang, W., Lai, Y.-H., Logg, C. R., Parker, W. B., Li, Y., Hong, J. S., Sorscher, E. J., Chen, T. C., & Kasahara, N. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.17 · Cited by 43 · see citing works
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo
Kaspera, R., Kirby, B. J., Sahele, T., Collier, A. C., Kharasch, E. D., Unadkat, J. D., & Totah, R. A. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.06.020 · Cited by 42 · see citing works
Ahmad, S., Casey, G. D., Sweeney, P., Tangney, M., & O’Sullivan, G. C. (2009) · Molecular Therapy · doi:10.1038/mt.2009.66 · Cited by 37 · see citing works
Chen, G., Tang, B., Yang, B., Chen, J., Zhou, J., Li, J., & Hua, Z. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4321-8 · Cited by 37 · see citing works
Sorscher, E. J., Hong, J. S., Allan, P. W., Waud, W. R., & Parker, W. B. (2012) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-012-1908-9 · Cited by 36 · see citing works
Somers, K. D., Brown, R. R., Holterman, D. A., Yousefieh, N., Glass, W. F., Wright, G. L., Schellhammer, P. F., Qian, J., & Ciavarra, R. P. (2003) · International Journal of Cancer · doi:10.1002/ijc.11464 · Cited by 36 · see citing works
Arora, P. K., & Jain, R. K. (2011) · Biodegradation · doi:10.1007/s10532-011-9512-y · Cited by 33 · see citing works
Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants
Vredenburg, G., den Braver-Sewradj, S. P., van Vugt‐Lussenburg, B. M. A., Vermeulen, N. P. E., Commandeur, J. N. M., & Vos, J. C. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.005 · Cited by 30 · see citing works
Valle, A., Borgne, S. L., Bolı́var, J., Cabrera, G., & Cantero, D. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3787-0 · Cited by 26 · see citing works
Han, X., Du, C., Zhang, C. L., Zheng, C. L., Wang, L., Li, D., Feng, Y. Y., DuPont, H. L., Jiang, Z., & Shi, Y. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.05.004 · Cited by 21 · see citing works
Dermatologic Infections in Cancer Patients
Gandhi, M. A., Brieva, J. C., & Lacouture, M. E. (2014) · Cancer treatment and research · doi:10.1007/978-3-319-04220-6_10 · Cited by 17 · see citing works
Simpson, W. M. (1947) · American Journal of Clinical Pathology · doi:10.1093/ajcp/17.7.513 · Cited by 14 · see citing works
Patschan, O., Holmäng, S., Hosseini, A., Liedberg, F., Ljungberg, B., Malmström, P., Rosell, J., & Jahnson, S. (2014) · Scandinavian Journal of Urology · doi:10.3109/21681805.2014.968868 · Cited by 13 · see citing works
Nguyen, A., Heil, E., Patel, N., Duffy, A. P., & Gilmore, S. (2015) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155214567161 · Cited by 10 · see citing works
Improving Drug Design: Considerations for the Structural Modification Process
Nassar, A. F. (2010) · doi:10.1002/9780470890387.ch4 · Cited by 4 · see citing works
Bacterial Systems for Gene Delivery to Systemic Tumors
Cummins, J., Cronin, M. A., van Pijkeren, J. P., Gahan, C. G. M., & Tangney, M. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0363-4_13 · Cited by 4 · see citing works
[Isolation of Haemophilus spp. from samples of pleural fluid: 11 years' review].
Olsina, M., Marcellés, A. F., Alegre, J., Falcó, V., de Sevilla, T. F., & Crespo, E. (1994) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Nassar A. F. in Biotransformation and Metabolite Elucidation of Xenobiotics 163– 216 (John Wiley & Sons, Inc., 2010).
Cited by
Sorted by citations
Molecular principles of metastasis: a hallmark of cancer revisited
Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,423 · see citing works
Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., et al. (2017) · Science · doi:10.1126/science.aah5043 · Cited by 1,817 · see citing works
The microbiome, cancer, and cancer therapy
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019) · Nature Medicine · doi:10.1038/s41591-019-0377-7 · Cited by 1,200 · see citing works
Chemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080 · see citing works
Stress and stability: applying the Anna Karenina principle to animal microbiomes
Zaneveld, J. R., McMinds, R., & Vega Thurber, R. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.121 · Cited by 977 · see citing works
Microbiota: a key orchestrator of cancer therapy
Roy, S., & Trinchieri, G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.13 · Cited by 883 · see citing works
The Microbiota of Breast Tissue and Its Association with Breast Cancer
Urbaniak, C., Gloor, G. B., Brackstone, M., Scott, L., Tangney, M., & Reid, G. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01235-16 · Cited by 625 · see citing works
Self-citationCullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K., & Elinav, E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.08.006 · Cited by 578 · see citing works
(2023) · doi:10.1038/s41392-022-01304-4 · Cited by 460 · see citing works
Current trends in drug metabolism and pharmacokinetics
Li, Y., Meng, Q., Yang, M., Liu, D., Hou, X., Tang, L. Y., Wang, X., Lyu, Y., Chen, X., Liu, K., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.001 · Cited by 409 · see citing works
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
The gut microbiome: an orchestrator of xenobiotic metabolism
Collins, S. L., & Patterson, A. D. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.001 · Cited by 341 · see citing works
Gut microbiome, big data and machine learning to promote precision medicine for cancer
Cammarota, G., Ianiro, G., Ahern, A., Carbone, C., Temko, A., Claesson, M. J., Gasbarrini, A., & Tortora, G. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0327-3 · Cited by 324 · see citing works
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies
Panebianco, C., Andriulli, A., & Pazienza, V. (2018) · Microbiome · doi:10.1186/s40168-018-0483-7 · Cited by 343 · see citing works
Targeting the gut microbiota for cancer therapy
Fernandes, M. R., Aggarwal, P., Costa, R. G. F., Cole, A. M., & Trinchieri, G. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00513-x · Cited by 290 · see citing works
Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy
Chrysostomou, D., Roberts, L. A., Marchesi, J. R., & Kinross, J. K. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.10.018 · Cited by 291 · see citing works
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Yang, Q., Wang, B., Zheng, Q., Li, H., Meng, X., Zhou, F., & Zhang, L. (2023) · Advanced Science · doi:10.1002/advs.202207366 · Cited by 249 · see citing works
Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored
Mikó, E., Kovàcs, T., Sebő, É., Tóth, J., Csonka, T., Ujlaki, G., Sipos, A., Szabó, J., Méhes, G., & Bai, P. (2019) · Cells · doi:10.3390/cells8040293 · Cited by 220 · see citing works
Yamamura, K., Izumi, D., Kandimalla, R., Sonohara, F., Baba, Y., Yoshida, N., Kodera, Y., Baba, H., & Goel, A. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0318 · Cited by 202 · see citing works
Sommariva, M., Noci, V. L., Bianchi, F., Camelliti, S., Balsari, A., Tagliabue, E., & Sfondrini, L. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03452-8 · Cited by 178 · see citing works
Psychotropics and the Microbiome: a Chamber of Secrets…
Cussotto, S., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5185-8 · Cited by 169 · see citing works
Microbiome and Breast Cancer: New Role for an Ancient Population
Eslami-S, Z., Majidzadeh-A, K., Halvaei, S., Babapirali, F., & Esmaeili, R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00120 · Cited by 153 · see citing works
The role of microbiome in rheumatoid arthritis treatment
Bodkhe, R., Balakrishnan, B., & Taneja, V. (2019) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x19844632 · Cited by 146 · see citing works
Carcinogenesis and therapeutics: the microbiota perspective
Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works
Microbiome dysbiosis in lung cancer: from composition to therapy
Liu, N., Ma, Q., Ge, Y., Yi, C., Wei, L., Tan, J.-C., Chu, Q., Li, J., Zhang, P., & Wang, H. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-00138-z · Cited by 145 · see citing works
The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome.
Enright, E. F., Gahan, C. G. M., Joyce, S. A., & Griffin, B. T. (2016) · PubMed Central · Cited by 139 · see citing works
Microbial markers in colorectal cancer detection and/or prognosis
Villéger, R., Lopès, A., Véziant, J., Gagnière, J., Barnich, N., Billard, E., Boucher, D., & Bonnet, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i22.2327 · Cited by 139 · see citing works
The Gut Microbiome in Pancreatic Disease
Akshintala, V. S., Talukdar, R., Singh, V. K., & Goggins, M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.045 · Cited by 131 · see citing works
Pancreatic cancer in 2021: What you need to know to win
Tonini, V., & Zanni, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5851 · Cited by 126 · see citing works
Chamseddine, A. N., Ducreux, M. P., Armand, J., Paolettí, X., Satar, T., Paci, A., & Mir, O. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.002 · Cited by 119 · see citing works
Intestinal Microbiota: A Novel Target to Improve Anti-Tumor Treatment?
Villéger, R., Lopès, A., Carrier, G., Véziant, J., Billard, E., Barnich, N., Gagnière, J., Vazeille, E., & Bonnet, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184584 · Cited by 119 · see citing works
Microbiota in cancer development and treatment
Raza, M. H., Gul, K., Arshad, A., Riaz, N., Waheed, U., Rauf, A., Aldakheel, F. M., Alduraywish, S. A., Rehman, M. U., Abdullah, M., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2816-0 · Cited by 120 · see citing works
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer
Parida, S., & Sharma, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.001 · Cited by 120 · see citing works
Blueprint for cancer research: Critical gaps and opportunities
Elmore, L. W., Greer, S. F., Daniels, E. C., Saxe, C. C., Melner, M. H., Krawiec, G. M., Cance, W. G., & Phelps, W. C. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21652 · Cited by 121 · see citing works
Intracellular bacteria in cancer—prospects and debates
Schorr, L., Mathies, M., Elinav, E., & Puschhof, J. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00446-9 · Cited by 113 · see citing works
Ševčíková, A., Izoldova, N., Števurková, V., Kasperova, B., Chovanec, M., Čierniková, S., & Mego, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010488 · Cited by 104 · see citing works
The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful!
Nandi, D., Parida, S., & Sharma, D. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221452 · Cited by 98 · see citing works
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
Wang, Y., Yang, G., You, L., Yang, J., Feng, M., Qiu, J., Zhao, F., Liu, Y., Cao, Z., Zheng, L., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1103-2 · Cited by 95 · see citing works
Microbiota–drug interactions: Impact on metabolism and efficacy of therapeutics
Wilkinson, E. M., Ilhan, Z. E., & Herbst‐Kralovetz, M. M. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.03.012 · Cited by 95 · see citing works
Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents
Geller, L. T., & Straussman, R. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1405139 · Cited by 91 · see citing works
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption
Allwardt, V., Ainscough, A. J., Viswanathan, P., Sherrod, S. D., MCLEAN, J. A. J., Haddrick, M., & Pensabene, V. (2020) · Bioengineering · doi:10.3390/bioengineering7030112 · Cited by 89 · see citing works
The human microbiome and cancer: a diagnostic and therapeutic perspective
Kandalai, S., Li, H., Zhang, N., Peng, H., & Zheng, Q. (2023) · Cancer Biology & Therapy · doi:10.1080/15384047.2023.2240084 · Cited by 93 · see citing works
Sequence-Based Characterization of Intratumoral Bacteria—A Guide to Best Practice
Walker, S. P., Tangney, M., & Claesson, M. J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00179 · Cited by 85 · see citing works
Lin, A., Xiong, M., Jiang, A., Huang, L., Wong, H. Z. H., Feng, S., Zhang, C., Yu, H., Chen, L., Chi, H., et al. (2025) · iMeta · doi:10.1002/imt2.70070 · Cited by 91 · see citing works
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 79 · see citing works
Microbiota as a mediator of cancer progression and therapy
Pope, J. L., Tomkovich, S., Yang, Y., & Jobin, C. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.021 · Cited by 79 · see citing works
Li, N., Bai, C., Zhao, L., Sun, Z., Ge, Y., & Li, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.781697 · Cited by 73 · see citing works
Common Oral Medications Lead to Prophage Induction in Bacterial Isolates from the Human Gut
Sutcliffe, S. G., Shamash, M., Hynes, A. P., & Maurice, C. F. (2021) · Viruses · doi:10.3390/v13030455 · Cited by 65 · see citing works
The Role of The Tumor Microbiome in Tumor Development and Its Treatment
Chen, Y., Wu, F., Wu, P., Xing, H., & Ma, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935846 · Cited by 66 · see citing works
Pancreatic Cancer, Gut Microbiota, and Therapeutic Efficacy
Zhang, X., Liu, Q., Liao, Q., & Zhao, Y. (2020) · Journal of Cancer · doi:10.7150/jca.37445 · Cited by 65 · see citing works
Balló, O., Tarazzit, I., Stratmann, J., Reinheimer, C., Hogardt, M., Wichelhaus, T. A., Kempf, V. A. J., Serve, H. L., Finkelmeier, F., & Brandts, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210991 · Cited by 64 · see citing works
Jaye, K. M., Li, C. G., & Bhuyan, D. J. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103429 · Cited by 62 · see citing works
A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma
Pandya, G., Kirtonia, A., Singh, A. P., Goel, A., Mohan, C. D., Rangappa, K. S., Pandey, A. K., Kapoor, S., Tandon, S., Sethi, G., et al. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.027 · Cited by 59 · see citing works
The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment
Gao, F., Yu, B., Rao, B., Sun, Y. H., Yu, J., Wang, D., Cui, G., & Ren, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051987 · Cited by 61 · see citing works
Gut microbiome: An intermediary to neurotoxicity
Dempsey, J. L., Little, M., & Cui, J. Y. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.005 · Cited by 62 · see citing works
The role of microbiome in pancreatic cancer
Li, J., Zhu, M., Kashyap, P., Chia, N., Tran, N. H., McWilliams, R. R., Bekaii‐Saab, T., & Ma, W. W. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09982-2 · Cited by 58 · see citing works
The intratumoral microbiome: Characterization methods and functional impact
Heymann, C. J. F., Bard, J., Heymann, M., Heymann, D., & Bobin‐Dubigeon, C. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.009 · Cited by 58 · see citing works
Choy, A. T. F., Carnevale, I., Coppola, S., Meijer, L. L., Geert Kazemier, M., Zaura, E., Deng, D., & Giovannetti, E. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1544495 · Cited by 58 · see citing works
Capula, M., Perán, M., Xu, G., Donati, V. L., Yee, D., Gregori, A., Assaraf, Y. G., Giovannetti, E., & Deng, D. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100864 · Cited by 56 · see citing works
Gut Microbiota Influences Experimental Outcomes in Mouse Models of Colorectal Cancer
Leystra, A. A., & Clapper, M. L. (2019) · Genes · doi:10.3390/genes10110900 · Cited by 56 · see citing works
Intratumoral microbiota: A new force in diagnosing and treating pancreatic cancer
Jiang, Z., Zhang, W., Zhang, Z., Sha, G., Wang, D., & Tang, D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216031 · Cited by 54 · see citing works
Komorowski, A. S., & Pezo, R. C. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05472-w · Cited by 54 · see citing works
The impact of tumor and gut microbiotas on cancer therapy: Beneficial or detrimental?
Hekmatshoar, Y., Saadat, Y. R., Khatibi, S. M. H., Özkan, T., Vahed, F. Z., Nariman‐Saleh‐Fam, Z., Gargari, B. P., Sunguroğlu, A., & Vahed, S. Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116680 · Cited by 52 · see citing works
MASS SPECTROMETRY‐BASED PERSONALIZED DRUG THERAPY
Cui, J., Wang, L., Tan, Z., Zhou, H., Zhan, X., & Yin, J. (2020) · Mass Spectrometry Reviews · doi:10.1002/mas.21620 · Cited by 51 · see citing works
Biomimetic Bacterial Membrane Vesicles for Drug Delivery Applications
Fazal, S., & Lee, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091430 · Cited by 51 · see citing works
Kovàcs, T., Mikó, E., Ujlaki, G., Yousef, H., Csontos, V., Uray, K., & Bai, P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10013-3 · Cited by 52 · see citing works
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer
Cianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., Gasbarrini, A., Gambassi, G., & Cammarota, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030501 · Cited by 50 · see citing works
Chemical Metabolism of Xenobiotics by Gut Microbiota
Nakov, R., & Velikova, T. V. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200303113830 · Cited by 50 · see citing works
Fulop, D. J., Zylberberg, H. M., Wu, Y. L., Aronson, A., Labiner, A. J., Wisnivesky, J. P., Cohen, D. J., Sigel, K. M., & Lucas, A. L. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.4254 · Cited by 48 · see citing works
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48 · see citing works
Ke, W., Saba, J. A., Yao, C.-H., Hilzendeger, M. A., Drangowska-Way, A., Joshi, C. J., Mony, V. K., Benjamin-Davalos, S., Zhang, S., Locasale, J. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16220-w · Cited by 48 · see citing works
Implications of the Human Gut–Brain and Gut–Cancer Axes for Future Nanomedicine
Javed, I., Cui, X., Wang, X., Mortimer, M., Andrikopoulos, N. K., Li, Y., Davis, T. P., Zhao, Y., Ke, P. C., & Chen, C. (2020) · ACS Nano · doi:10.1021/acsnano.0c07258 · Cited by 47 · see citing works
Exploring the Potential of Breast Microbiota as Biomarker for Breast Cancer and Therapeutic Response
Dieleman, S., Aarnoutse, R., Ziemons, J., Kooreman, L. F. S., Boleij, A., & Smidt, M. L. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.02.020 · Cited by 47 · see citing works
Zidi, O., Souai, N., Raies, H., Ayed, F. B., Mézlini, A., Mezrioui, S., Tranchida, F., Sabatier, J., Mosbah, A., Cherif, A., et al. (2021) · Molecules · doi:10.3390/molecules26082266 · Cited by 48 · see citing works
Exploring the role of gut microbiota in advancing personalized medicine
Huang, G., Khan, R., Zheng, Y., Lee, P.-C., Li, Q., & Khan, I. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1274925 · Cited by 47 · see citing works
The role of the microbiome in drug resistance in gastrointestinal cancers
Garajová, I., Balsano, R., Wang, H., Leonardi, F., Giovannetti, E., Deng, D., & Peters, G. J. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2021.1844007 · Cited by 44 · see citing works
Aarnoutse, R., Ziemons, J., Hillege, L. E., de Vos‐Geelen, J., de Boer, M., Bisschop, S. M. P., Vriens, B. E. P. J., Vincent, J., van de Wouw, A. J., Le, N. G., et al. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00455-5 · Cited by 46 · see citing works
von Frieling, J., Fink, C., Hamm, J., Klischies, K., Förster, M., Bosch, T. C. G., Roeder, T., Rosenstiel, P. C., & Sommer, F. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02020 · Cited by 44 · see citing works
Dalmasso, G., Cougnoux, A., Faïs, T., Bonnin, V., Mottet-Auselo, B., Nguyen, H. T. T., Sauvanet, P., Barnich, N., Jary, M., Pezet, D., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2310215 · Cited by 43 · see citing works
Yin, Y., Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Anaerobe · doi:10.1016/j.anaerobe.2021.102361 · Cited by 42 · see citing works
Dey, P., & Chaudhuri, S. R. (2022) · Biology · doi:10.3390/biology11050757 · Cited by 42 · see citing works
Progress on the pathological tissue microenvironment barrier-modulated nanomedicine
Han, H., Xing, L., Chen, B., Liu, Y., Zhou, T., Wang, Y., Zhang, L., Li, L., Cho, C., & Jiang, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115051 · Cited by 41 · see citing works
Palko-Łabuz, A., Maksymowicz, J., Sobieszczańska, B., Wikiera, A., Skonieczna, M., Wesołowska, O., & Środa-Pomianek, K. (2021) · Cancers · doi:10.3390/cancers13122952 · Cited by 41 · see citing works
Tannic Acid-Modified Silver Nanoparticles for Antibacterial and Anticancer Applications
Ha, W., Yang, J., & Shi, Y. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c01291 · Cited by 42 · see citing works
Microbiome and pancreatic cancer: time to think about chemotherapy
de Castilhos, J., Tillmanns, K., Blessing, J., Larano, A., Borisov, V., & Stein‐Thoeringer, C. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2374596 · Cited by 41 · see citing works
The promise and challenge of cancer microbiome research
Manzoor, S. S., Doedens, A. M., & Burns, M. B. (2020) · Genome biology · doi:10.1186/s13059-020-02037-9 · Cited by 40 · see citing works
Chen, J., Li, T., Liang, J., Huang, Q., Huang, J., Ke, Y., & Sun, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112443 · Cited by 39 · see citing works
Guevara‐Ramírez, P., Cadena-Ullauri, S., Paz‐Cruz, E., Ruiz‐Pozo, V. A., Tamayo‐Trujillo, R., Cabrera‐Andrade, A., & Zambrano, A. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910255 · Cited by 37 · see citing works
Yin, B., Wang, X., Fang, Y., Li, Y., & Lu, P. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.899111 · Cited by 37 · see citing works
Jiang, M., Yang, Z., Dai, J., Wu, T., Jiao, Z., Yu, Y., Kang, N., Chen, W., & Yang, A. (2023) · MedComm · doi:10.1002/mco2.376 · Cited by 36 · see citing works
Microbiome as an Immunological Modifier
Kumar, M., Singh, P., Murugesan, S., Vétizou, M., McCulloch, J. A., Badger, J. H., Trinchieri, G., & Khodor, S. A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_27 · Cited by 36 · see citing works
Elsalem, L., Jum’ah, A. A., Alfaqih, M. A., & Aloudat, O. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s243337 · Cited by 38 · see citing works
Li, X., Wu, T., Zhang, Z., Liu, S., Cui, H., Fan, Z., Wang, B., & Hai, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139939 · Cited by 36 · see citing works
Mousa, S., Sarfraz, M., & Mousa, W. K. (2023) · Metabolites · doi:10.3390/metabo13050674 · Cited by 37 · see citing works
Exploring the microbiota to better understand gastrointestinal cancers physiology
Panebianco, C., Potenza, A., Andriulli, A., & Pazienza, V. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1163 · Cited by 45 · see citing works
Microbiota: Overview and Implication in Immunotherapy-Based Cancer Treatments
Brandi, G., & Frega, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112699 · Cited by 35 · see citing works
A Perspective on the Role of Microbiome for Colorectal Cancer Treatment
Kalasabail, S., Engelman, J., Zhang, L. Y., El-Omar, E. M., & Yim, H. C. H. (2021) · Cancers · doi:10.3390/cancers13184623 · Cited by 35 · see citing works
Xi, J., Wang, Y., Gao, X. J., Huang, Y., Chen, J., Chen, Y., Fan, L., & Gao, L. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101395 · Cited by 35 · see citing works
Long, J., Wang, J., Xiao, C., You, F., Jiang, Y., & Li, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01831-3 · Cited by 34 · see citing works
- Authors
- Lehouritis, P., Cummins, J., Stanton, M., Murphy, C. T., McCarthy, F. O., Reid, G., Urbaniak, C., Byrne, W. L., & Tangney, M.
- Affiliations
- University College Cork (IE)
- Western University (CA)
- Corresponding author
- Tangney, Mark
- Venue
- Scientific Reports
- Published
- 2015-09-29
- Volume
- 5
- Issue
- 1
- Pages
- 14554-14554
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4586607
- OpenAlex
- W1945551477
- Cited by
- 313
- References
- 54
- Citations by year
- 2026: 31 · 2025: 36 · 2024: 46 · 2023: 44 · 2022: 39 · 2021: 36 · 2020: 31 · 2019: 27 · 2018: 12 · 2017: 8 · 2016: 3
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
- Keywords
- bacteria, chemotherapeutic drugs, drug efficacy, chemoresistance, gemcitabine, CB1954, cladribine, fludarabine, cancer cell lines, mouse tumor model, off-target toxicity, infection and cancer
- MeSH terms
- Gemcitabine, Animals, Antineoplastic Agents, Aziridines, Biotransformation, Colonic Neoplasms, Deoxycytidine, Escherichia coli, Female, Injections, Subcutaneous, Listeria, Neoplasm Transplantation, Skin, Vidarabine, Injections, Intralesional, Treatment Outcome, Cladribine, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
