The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats
Open accessAbstract
Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut microbial composition with prebiotic treatment reduces maternal energy intake, decreases gestational weight gain and prevents increased adiposity in dams and their offspring. Maternal serum metabolomics analysis, along with satiety hormone and gut microbiota analysis, identified maternal metabolic signatures that could be implicated in programming offspring obesity risk and highlighted the potential influence of maternal gut microbiota on maternal and offspring metabolism. In particular, the metabolomic signature of insulin resistance in obese rats normalized when dams consumed the prebiotic. In summary, prebiotic intake during pregnancy and lactation improves maternal metabolism in diet-induced obese rats in a manner that attenuates the detrimental nutritional programming of offspring associated with maternal obesity. Overall, these findings contribute to our understanding of the maternal mechanisms influencing the developmental programming of offspring obesity and provide compelling pre-clinical evidence for a potential strategy to improve maternal and offspring metabolic outcomes in human pregnancy.
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Cites
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Maternal Nutrition and Fetal Development
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Self-citation
Cited by
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634
Self-citationGut microbial metabolites as multi-kingdom intermediates
Krautkramer, K. A., Fan, J., & Bäckhed, F. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0438-4 · Cited by 1,398
Microbial Changes during Pregnancy, Birth, and Infancy
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Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 466
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism
Amabebe, E., Robert, F. O., Agbalalah, T., & Orubu, E. S. F. (2020) · British Journal of Nutrition · doi:10.1017/s0007114520000380 · Cited by 455
Metadata
- Authors
- Paul, H. A., Bomhof, M. R., Vogel, H. J., & Reimer, R. A.
- Venue
- Scientific Reports
- Published
- 2016-02-12
- Volume
- 6
- Issue
- 1
- Pages
- 20683-20683
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2259933691
- Cited by
- 173
- References
- 10
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- gold
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